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Fenortho
Fenortho (generic name: fenoprofen calcium) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and swelling associated with conditions such as osteoarthritis, rheumatoid arthritis, and mild to moderate pain. It works by reducing the production of chemicals that cause inflammation, pain, and fever. Fenortho is primarily prescribed to manage chronic conditions involving joint inflammation and pain or for short-term relief of acute musculoskeletal pain.
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Frequently Asked Questions
How long does it take for Fenortho to work?
Fenortho typically starts working within 30 to 60 minutes to relieve pain and inflammation.
Can I take Fenortho with other pain medications?
You can take Fenortho with acetaminophen (Tylenol), but avoid combining it with other NSAIDs like ibuprofen or naproxen, as this increases the risk of gastrointestinal side effects.
What should I do if I miss a dose of Fenortho?
If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Fenortho safe for long-term use?
Long-term use of Fenortho is associated with increased risks of gastrointestinal bleeding, kidney damage, and cardiovascular events. It should be used at the lowest effective dose for the shortest possible duration.
Can Fenortho cause stomach ulcers?
Yes, like other NSAIDs, Fenortho can cause stomach ulcers and gastrointestinal bleeding, especially with long-term use. Taking the medication with food or milk can help reduce this risk.
Comprehensive Drug Guide
How Does Fenortho Work?
Fenortho works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins play a role in inflammation, pain, and fever. By blocking the production of prostaglandins, Fenortho helps to reduce inflammation, alleviate pain, and lower fever.
Common Dosages
The typical dosage for Fenortho depends on the condition being treated:
- For osteoarthritis and rheumatoid arthritis: The recommended dose is 400 mg to 600 mg three or four times daily, depending on the severity of the condition.
- For mild to moderate pain: The usual dose is 200 mg to 400 mg every 4 to 6 hours as needed for pain relief.
Typical Dosing
- For arthritis (osteoarthritis or rheumatoid arthritis): The standard dose is 400 mg to 600 mg three or four times daily.
- For acute pain relief: The recommended dose is 200 mg to 400 mg every 4 to 6 hours as needed, not to exceed a total daily dose of 2400 mg.
Typical Dosing
FDA Approved Indications
- Osteoarthritis: To reduce joint pain, swelling, and stiffness associated with the degeneration of joint cartilage.
- Rheumatoid arthritis: To relieve pain, swelling, and stiffness associated with the autoimmune condition affecting the joints.
- Mild to moderate pain: For relief of pain caused by musculoskeletal conditions, such as sprains, strains, or other acute injuries.
Who Shouldn't Take Fenortho?
- Known hypersensitivity to fenoprofen or other NSAIDs.
- Active gastrointestinal bleeding, peptic ulcers, or a history of gastrointestinal perforation or bleeding.
- Severe kidney disease.
- Coronary artery bypass graft (CABG) surgery for perioperative pain.
- Asthma, urticaria, or allergic reactions triggered by aspirin or other NSAIDs.
Advice From The Pharmacist
- Take Fenortho with food or milk to minimize the risk of stomach upset and gastrointestinal irritation.
- Avoid alcohol while taking Fenortho, as it can increase the risk of stomach bleeding.
- Use Fenortho at the lowest effective dose for the shortest possible duration to reduce the risk of serious side effects.
- Monitor for signs of gastrointestinal bleeding (black stools, vomiting blood), heart attack, or stroke (chest pain, shortness of breath).
- If you have a history of kidney problems, consult your healthcare provider, as Fenortho may affect kidney function.
Side Effects of Fenortho
Common Side Effects
- Stomach upset or nausea
- Heartburn
- Dizziness
- Headache
- Constipation
Uncommon/Severe Side Effects
- Gastrointestinal bleeding (black stools, vomiting blood)
- Liver damage (yellowing of the skin or eyes, dark urine)
- Kidney problems (reduced urination, swelling in the legs)
- Heart attack or stroke
- Severe allergic reactions (rash, hives, difficulty breathing)
Risks and Warnings of Fenortho
- Gastrointestinal Risk: Fenortho increases the risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines. Elderly patients are at higher risk for these events.
- Cardiovascular Risk: NSAIDs like Fenortho increase the risk of serious cardiovascular events, such as heart attack and stroke, particularly with long-term use.
- Kidney Risk: Fenortho can impair kidney function, especially in patients with pre-existing kidney disease or those taking medications that affect the kidneys.
- Liver Risk: Fenortho can cause liver damage in some individuals, so regular monitoring of liver function is recommended during long-term use.
Interactions with Fenortho
Common Drug Interactions
- Anticoagulants (e.g., warfarin): Fenortho can increase the risk of bleeding when taken with blood thinners.
- Other NSAIDs or aspirin: Combining Fenortho with other NSAIDs increases the risk of gastrointestinal bleeding and ulcers.
- ACE inhibitors and diuretics: Fenortho may reduce the effectiveness of blood pressure medications, leading to fluid retention and kidney problems.
- Corticosteroids (e.g., prednisone): Concomitant use increases the risk of gastrointestinal side effects, including ulcers and bleeding.
Alternatives to Fenortho
- Ibuprofen (Advil, Motrin): A widely used NSAID for treating pain and inflammation.
- Naproxen (Aleve): An NSAID that provides longer-lasting relief for pain and inflammation.
- Celecoxib (Celebrex): A COX-2 inhibitor NSAID that may have fewer gastrointestinal side effects compared to non-selective NSAIDs like Fenortho.
- Acetaminophen (Tylenol): A pain reliever for those who cannot take NSAIDs, although it lacks anti-inflammatory effects.
