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Ethynodiol Diac-Eth Estradiol
Ethynodiol Diacetate-Ethinyl Estradiol is a combination oral contraceptive used to prevent pregnancy. It contains two active hormones: ethynodiol diacetate (a progestin) and ethinyl estradiol (an estrogen). This combination works by preventing ovulation, thickening cervical mucus to block sperm, and changing the uterine lining to prevent a fertilized egg from attaching. In addition to birth control, this medication may help regulate menstrual cycles, reduce menstrual cramps, and lower the risk of ovarian cysts.
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Frequently Asked Questions
What should I do if I miss a pill?
If you miss one active pill, take it as soon as you remember and then continue your regular schedule. If you miss two or more pills, refer to the instructions in the package insert, as you may need to use backup contraception.
Can Ethynodiol Diacetate-Ethinyl Estradiol help with acne?
Yes, some women may notice improvements in their acne while taking this combination contraceptive, as it can help balance hormone levels that contribute to acne breakouts.
Does Ethynodiol Diacetate-Ethinyl Estradiol cause weight gain?
Weight changes are possible, though significant weight gain is uncommon. Most women experience minimal to no weight changes while taking oral contraceptives.
Can I take Ethynodiol Diacetate-Ethinyl Estradiol while breastfeeding?
This combination contraceptive is generally not recommended during breastfeeding, as it may reduce milk supply. A progestin-only pill is often preferred for nursing mothers.
How long does it take for Ethynodiol Diacetate-Ethinyl Estradiol to be effective?
When started on the first day of your period, Ethynodiol Diacetate-Ethinyl Estradiol is effective immediately. If started at any other time, use a backup form of contraception (e.g., condoms) for the first 7 days of taking the pill.
Comprehensive Drug Guide
How Does Ethynodiol Diac-Eth Estradiol Work?
- Prevents ovulation: Ethynodiol diacetate and ethinyl estradiol prevent the release of an egg from the ovaries.
- Thickens cervical mucus: Makes it more difficult for sperm to reach the uterus and fertilize an egg.
- Alters the uterine lining: Makes the uterine lining less suitable for implantation, should fertilization occur.
What is Ethynodiol Diac-Eth Estradiol Used For?
FDA indications: Ethynodiol is primarily used to prevent pregnancy. It has also been used to treat severe acne.
Offlabel uses: It may also be used offlabel to control abnormal uterine bleeding, alleviate
menstrual pain, and manage endometriosis.
Common Dosages
The typical dosage for Ethynodiol Diacetate-Ethinyl Estradiol is:
- One tablet daily: Typically containing 0.5 mg ethynodiol diacetate and 30 mcg ethinyl estradiol. The regimen usually consists of 21 active tablets followed by 7 inactive tablets, during which time withdrawal bleeding (menstruation) occurs.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy.
- Regulation of menstrual cycles.
- Reduction of menstrual cramps.
- Lowering the risk of ovarian cysts.
Off-Label Uses
Who Shouldn't Take Ethynodiol Diac-Eth Estradiol?
- Known hypersensitivity to estrogens, progestins, or any ingredients in the formulation.
- History of blood clots, stroke, or heart attack.
- Liver disease or liver tumors.
- Breast cancer or other estrogen- or progestin-dependent cancers.
- Uncontrolled hypertension.
- Migraines with aura.
- Undiagnosed abnormal vaginal bleeding.
Advice From The Pharmacist
- Take the pill at the same time each day to maintain consistent hormone levels and maximize contraceptive effectiveness.
- If you miss a dose, follow the instructions in the package insert for missed pills, and consider using a backup form of contraception (e.g., condoms) until the pill has been taken correctly for 7 consecutive days.
- Smoking increases the risk of serious cardiovascular side effects, especially in women over 35. Avoid smoking while using this medication.
- Inform your healthcare provider if you experience any unusual vaginal bleeding, as it may require medical evaluation.
Side Effects of Ethynodiol Diac-Eth Estradiol
Common Side Effects
- Nausea
- Headache
- Breast tenderness
- Weight changes
- Mood changes
- Spotting or breakthrough bleeding, especially during the first few months of use
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke or heart attack
- Severe allergic reactions (hives, swelling, difficulty breathing)
- Liver problems (jaundice, dark urine, upper abdominal pain)
- Breast or cervical cancer
Risks and Warnings of Ethynodiol Diac-Eth Estradiol
- Cardiovascular Risk: The use of combination oral contraceptives is associated with an increased risk of blood clots, stroke, and heart attack, particularly in women who smoke and are over the age of 35. Regular cardiovascular monitoring is recommended for at-risk patients.
- Breast and Cervical Cancer: Long-term use of hormonal contraceptives may increase the risk of breast cancer and cervical cancer, though the risk decreases after discontinuation. Regular screening is recommended.
- Liver Toxicity: Rarely, combination oral contraceptives can lead to liver tumors or other liver issues. Report any symptoms of liver problems, such as jaundice or dark urine, to your healthcare provider.
Interactions with Ethynodiol Diac-Eth Estradiol
Common Drug Interactions
- Antibiotics (e.g., rifampin): May reduce the effectiveness of oral contraceptives, increasing the risk of pregnancy.
- Anticonvulsants: Certain seizure medications can lower the effectiveness of Ethynodiol Diacetate-Ethinyl Estradiol.
- St. John’s Wort: Can reduce the effectiveness of oral contraceptives and increase the risk of breakthrough bleeding.
- Blood thinners (e.g., warfarin): May require dosage adjustments when taken with hormonal contraceptives.
Alternatives to Ethynodiol Diac-Eth Estradiol
- Norgestimate-Ethinyl Estradiol: Another combination oral contraceptive containing different active ingredients but used for similar purposes.
- Drospirenone-Ethinyl Estradiol (Yaz, Yasmin): A combination contraceptive that may also help with acne and premenstrual dysphoric disorder (PMDD).
- Progestin-only pills: An option for women who cannot take estrogen, often called the "mini-pill."
- IUD (Intrauterine Device): A long-term, reversible form of contraception, available in hormonal and non-hormonal (copper) options.
