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YAZ
YAZ is a combination oral contraceptive pill (OCP) containing drospirenone (3 mg) and ethinyl estradiol (0.02 mg). It is primarily used for preventing pregnancy but is also approved for treating acne, premenstrual dysphoric disorder (PMDD), and to help with moderate acne in women who also want contraception. The combination of these hormones works by preventing ovulation, thickening cervical mucus, and altering the uterine lining, making it more difficult for sperm to reach an egg or for a fertilized egg to implant.
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Frequently Asked Questions
How long does it take for YAZ to become effective?
If you start taking YAZ on the first day of your period, it is effective immediately. If you start it at any other time, use backup contraception (like condoms) for the first 7 days.
Can YAZ be used to treat acne?
Yes, YAZ is FDA-approved for the treatment of moderate acne in women who are also seeking contraception. It helps reduce acne by regulating hormones that contribute to skin oil production.
What should I do if I miss a dose of YAZ?
If you miss one active pill, take it as soon as you remember, even if that means taking two pills in one day. If you miss more than one pill, follow the instructions on the package or consult your healthcare provider for guidance. You may need to use additional contraception for the rest of your cycle.
Can I take YAZ if I smoke?
Women over the age of 35 who smoke should not use YAZ, as it significantly increases the risk of blood clots, stroke, and heart attack. Talk to your doctor about alternative birth control options.
Does YAZ protect against sexually transmitted infections (STIs)?
No, YAZ does not protect against STIs. Use condoms to reduce the risk of STIs.
Comprehensive Drug Guide
How Does YAZ Work?
YAZ works by combining drospirenone (a progestin) and ethinyl estradiol (an estrogen). This combination inhibits the release of eggs (ovulation) during the menstrual cycle. It also thickens the cervical mucus, which makes it harder for sperm to reach the egg, and changes the lining of the uterus to prevent attachment of a fertilized egg.
Common Dosages
- 24 active tablets: each containing 3 mg drospirenone and 0.02 mg ethinyl estradiol
- 4 placebo tablets: hormone-free tablets for the final 4 days of the cycle
Typical Dosing
- Take one active tablet daily for 24 days, followed by one placebo tablet daily for 4 days to complete a 28-day cycle. Start a new pack immediately after finishing the previous one, with no breaks between packs.
- It is important to take the pill at the same time every day to maintain consistent hormone levels and ensure effectiveness.
Typical Dosing
FDA Approved Indications
- Pregnancy prevention
- Treatment of moderate acne in women who desire contraception
- Premenstrual dysphoric disorder (PMDD)
Who Shouldn't Take YAZ?
- History of blood clots (e.g., deep vein thrombosis, pulmonary embolism)
- Uncontrolled high blood pressure
- Heart disease or stroke
- Severe liver disease
- Kidney disease
- Known hypersensitivity to drospirenone or ethinyl estradiol
- Migraines with aura
- Women over 35 who smoke
Advice From The Pharmacist
- Take YAZ at the same time every day, whether or not you are experiencing a menstrual period. Consistent timing increases its effectiveness.
- If you miss a dose, follow the instructions on the package or contact your healthcare provider. Missing doses may increase the risk of pregnancy, and additional contraception (such as condoms) may be needed for a short time.
- YAZ can increase the risk of blood clots, particularly in women who smoke or are over 35. Avoid smoking while using YAZ.
- It may take a few months for your body to adjust to the hormones in YAZ. During this time, you may experience irregular periods, spotting, or breakthrough bleeding.
Side Effects of YAZ
Common Side Effects
- Nausea
- Headaches
- Breast tenderness
- Weight gain or changes in appetite
- Mood changes, including depression
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke or heart attack (especially in smokers and women over 35)
- High blood pressure
- Liver problems (yellowing of the skin or eyes, dark urine)
Risks and Warnings of YAZ
- Blood Clots: YAZ has a higher risk of causing blood clots compared to some other birth control pills, particularly in women who smoke or have other risk factors for clots.
- Hyperkalemia: Drospirenone can raise potassium levels, so women with kidney, liver, or adrenal disease should be monitored for electrolyte imbalances.
- High Blood Pressure: Regular monitoring of blood pressure is recommended, as birth control pills like YAZ can increase blood pressure in some individuals.
- Liver Health: Hormonal contraceptives like YAZ may affect liver function, so inform your healthcare provider if you have a history of liver problems.
Interactions with YAZ
Common Drug Interactions
- Certain medications (e.g., antibiotics like rifampin or anticonvulsants like carbamazepine) may reduce the effectiveness of YAZ, increasing the risk of pregnancy. Use additional contraception while taking these medications.
- Potassium-sparing diuretics: Drospirenone in YAZ can increase potassium levels, so using it alongside medications that also raise potassium (e.g., ACE inhibitors, NSAIDs) may increase the risk of hyperkalemia.
- St. John’s Wort: This herbal supplement may reduce the effectiveness of YAZ, leading to an increased risk of pregnancy.
Alternatives to YAZ
- Ortho Tri-Cyclen: Another combination oral contraceptive used for birth control and acne treatment.
- NuvaRing: A vaginal ring that releases hormones similar to those in YAZ, used for birth control.
- Loestrin: A combination birth control pill with a lower dose of estrogen.
- Non-hormonal methods (e.g., condoms, copper IUD): Alternatives for women who cannot or prefer not to use hormonal contraception.