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E.E.S. Granules
E.E.S. Granules (erythromycin ethylsuccinate) is a macrolide antibiotic used to treat a wide variety of bacterial infections, including respiratory infections, skin infections, ear infections, and intestinal infections. It is also used to prevent certain infections in newborns. Erythromycin works by inhibiting the growth of bacteria by interfering with their ability to produce essential proteins. E.E.S. Granules are available as an oral suspension, making it easier for patients who have difficulty swallowing tablets or capsules.
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Frequently Asked Questions
How long does it take for E.E.S. Granules to start working?
You may begin to see improvement in your symptoms within a few days of starting treatment, but it is important to complete the full course of medication to ensure the infection is fully treated.
Can I take E.E.S. Granules with food?
E.E.S. Granules should be taken on an empty stomach for the best absorption, but if stomach upset occurs, you can take it with food after consulting your doctor.
What should I do if I miss a dose of E.E.S. Granules?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take the next one at the regular time. Do not double up on doses.
Is E.E.S. Granules safe during pregnancy?
E.E.S. Granules are generally considered safe during pregnancy, but always consult your doctor before taking any medication during pregnancy.
Can E.E.S. Granules treat viral infections like the flu?
No, E.E.S. Granules are an antibiotic and are only effective against bacterial infections. They will not work for viral infections like the flu or the common cold.
Comprehensive Drug Guide
How Does E.E.S. Granules Work?
Erythromycin, the active ingredient in E.E.S. Granules, works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit of bacteria, preventing the bacteria from producing proteins necessary for their growth and survival. This action helps stop the spread of infection.
Common Dosages
- Granules for oral suspension: 200 mg/5 mL, 400 mg/5 mL
Typical Dosing
- For bacterial infections: The typical dose for adults and children is 400 mg every 6-12 hours, depending on the severity of the infection.
- For prevention of rheumatic fever: 400 mg twice daily, as prescribed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Upper and lower respiratory tract infections
- Skin and soft tissue infections
- Ear infections (otitis media)
- Pertussis (whooping cough)
- Prevention of rheumatic fever
Who Shouldn't Take E.E.S. Granules?
- Known hypersensitivity to erythromycin or other macrolides
- Severe liver disease
- History of arrhythmias or heart problems
Advice From The Pharmacist
- Mix the granules with water according to the instructions provided to create the oral suspension. Shake the bottle well before each use.
- Store the suspension in the refrigerator and discard any unused portion after 10 days.
- Take E.E.S. Granules on an empty stomach (at least 1 hour before or 2 hours after meals) for the best absorption, unless otherwise directed by your doctor.
- Complete the full course of the medication, even if symptoms improve, to ensure the infection is fully treated.
Side Effects of E.E.S. Granules
Common Side Effects
- Nausea
- Diarrhea
- Stomach pain
- Vomiting
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Liver problems (jaundice, dark urine)
- Heart rhythm changes (QT prolongation)
Risks and Warnings of E.E.S. Granules
- Liver Health: E.E.S. Granules may cause liver problems, particularly in patients with preexisting liver conditions. Regular monitoring of liver function is advised for long-term use.
- QT Prolongation: Erythromycin can prolong the QT interval and lead to serious heart rhythm problems, especially in individuals with a history of heart disease.
- Allergic Reactions: Severe allergic reactions are possible, including anaphylaxis. Discontinue use and seek immediate medical attention if symptoms of an allergic reaction occur.
Interactions with E.E.S. Granules
Common Drug Interactions
- Warfarin: Erythromycin can increase the effects of warfarin, leading to an increased risk of bleeding.
- Statins: Combining erythromycin with statins (e.g., simvastatin, atorvastatin) may increase the risk of muscle toxicity (rhabdomyolysis).
- Theophylline: E.E.S. Granules can increase the blood levels of theophylline, potentially leading to toxicity.
Alternatives to E.E.S. Granules
- Azithromycin (Zithromax): Another macrolide antibiotic used to treat similar bacterial infections with a longer half-life and more convenient dosing.
- Clarithromycin (Biaxin): Another macrolide antibiotic that is effective against a variety of bacterial infections.
- Amoxicillin: A penicillin antibiotic commonly used for respiratory infections and ear infections, particularly in patients who cannot take macrolides.