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Doxylamine-Pyridoxine
Doxylamine-Pyridoxine is a combination medication used to treat nausea and vomiting during pregnancy (morning sickness). Doxylamine is an antihistamine that helps reduce nausea, while pyridoxine (vitamin B6) is a vitamin that can help alleviate symptoms of nausea. This combination is often prescribed when other remedies, such as dietary changes, are not effective in managing pregnancy-related nausea and vomiting.
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Frequently Asked Questions
Can I take doxylamine-pyridoxine if I’m still in my first trimester?
Yes, this medication is often prescribed early in pregnancy to manage morning sickness, and it is considered safe for both the mother and baby.
Will doxylamine make me feel drowsy?
Yes, doxylamine is known to cause drowsiness, so it’s best to take the medication at night. If you need to take doses during the day, avoid activities that require full alertness.
How long should I take doxylamine-pyridoxine?
You can take the medication for as long as your healthcare provider recommends, which may be throughout your pregnancy or until your nausea subsides.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Can I take additional vitamin B6 while on doxylamine-pyridoxine?
It is generally safe to continue taking prenatal vitamins, which often contain vitamin B6, while using this medication. However, consult your healthcare provider for personalized advice.
Comprehensive Drug Guide
How Does Doxylamine-Pyridoxine Work?
The combination works in two ways: Doxylamine blocks histamine receptors in the body, which helps reduce nausea, while pyridoxine is believed to help regulate metabolism and reduce nausea by affecting neurotransmitters in the brain. Together, they provide relief from the symptoms of morning sickness by targeting different mechanisms involved in nausea.
Common Dosages
- Delayed-release tablets containing 10 mg of doxylamine and 10 mg of pyridoxine.
Typical Dosing
- The typical starting dose is two tablets at bedtime. If symptoms persist, one tablet can be taken in the morning, and an additional tablet can be taken mid-afternoon if necessary.
- Dosage adjustments may be made based on the severity of nausea and vomiting, but the maximum recommended dose is four tablets per day.
Typical Dosing
FDA Approved Indications
Nausea and vomiting of pregnancy (morning sickness) when conservative management fails
Who Shouldn't Take Doxylamine-Pyridoxine?
- Known hypersensitivity to doxylamine, pyridoxine, or any components of the medication.
- Patients taking monoamine oxidase inhibitors (MAOIs).
- Individuals with conditions such as glaucoma, urinary retention, or asthma, which may be worsened by antihistamines.
Advice From The Pharmacist
- Take doxylamine-pyridoxine on an empty stomach with a glass of water to improve its absorption.
- Do not crush, chew, or split the delayed-release tablets, as this can affect the way the medication is absorbed.
- If the medication makes you drowsy, avoid activities that require full alertness, such as driving or operating machinery.
- Continue taking prenatal vitamins along with this medication, as pyridoxine is safe during pregnancy.
- Consult your healthcare provider before starting any new medications, as certain drugs can interact with doxylamine.
Side Effects of Doxylamine-Pyridoxine
Common Side Effects
- Drowsiness or sedation
- Dry mouth
- Dizziness
- Blurred vision
- Constipation
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, difficulty breathing)
- Confusion or disorientation in elderly patients
Risks and Warnings of Doxylamine-Pyridoxine
- Drowsiness: Doxylamine can cause significant drowsiness, so avoid activities that require full alertness until you know how the medication affects you.
- Overdose Risk: Taking more than the recommended dose can increase the risk of severe side effects, including excessive sedation or confusion.
- Interactions with Other Medications: Be cautious when combining this medication with other CNS depressants such as alcohol, sleep aids, or anxiety medications, as it may increase the sedative effects.
Interactions with Doxylamine-Pyridoxine
Common Drug Interactions
- CNS depressants: Combining doxylamine-pyridoxine with alcohol, sleep medications, or sedatives can increase drowsiness and sedation.
- Monoamine oxidase inhibitors (MAOIs): These can interact with doxylamine and lead to increased side effects such as drowsiness and dry mouth.
- Anticholinergic medications: Drugs with anticholinergic properties may increase the risk of side effects like dry mouth, blurred vision, and urinary retention.
Alternatives to Doxylamine-Pyridoxine
- Ginger supplements: Often used as a natural remedy for nausea during pregnancy.
- Meclizine (Antivert): Another antihistamine used for nausea and vomiting.
- Promethazine (Phenergan): A stronger antiemetic used for severe nausea and vomiting.
- Ondansetron (Zofran): A commonly used medication for nausea, although its safety in pregnancy is still under review.
