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Doxercalciferol
Doxercalciferol is a type of medication known as a vitamin D analog. It's used primarily for patients with chronic kidney disease who are undergoing dialysis, as they often struggle with maintaining the right balance of phosphate and calcium in their blood. Common side effects include headache, nausea, vomiting, or dry mouth, but your healthcare provider will typically ensure the benefits are worth these potential issues.
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Frequently Asked Questions
Can I stop taking Doxercalciferol if my parathyroid hormone levels are back to normal?
You should not stop taking your medication without first consulting your doctor as they will need to regularly check your levels and adjust your dose as necessary.
Can I take Doxercalciferol if I have high levels of calcium in my body?
No, you should not take Doxercalciferol if you have hypercalcemia as this medication may increase your calcium levels even more.
Does Doxercalciferol cure kidney disease?
No, Doxercalciferol does not cure kidney disease. It helps to manage high parathyroid hormone levels which can result from kidney disease.
Should I take Doxercalciferol if I am pregnant?
You should consult your healthcare provider before starting to take Doxercalciferol if you're planning to become pregnant, are pregnant, or are breastfeeding.
Comprehensive Drug Guide
How Does Doxercalciferol Work?
Doxercalciferol is a synthetic vitamin D analog that promotes the absorption of calcium and reduces parathyroid hormone (PTH) levels in the body, helping manage mineral balance.
What is Doxercalciferol Used For?
FDA indications: Doxercalciferol is used for the management of secondary hyperparathyroidism in patients with chronic kidney disease who are on dialysis.
Common Dosages
Injection: 2 mcg/mL (singleuse vial)
Capsules: 0.5 mcg, 1 mcg, 2.5 mcg.
Typical Dosing
FDA Approved Indications
- Secondary hyperparathyroidism in patients with chronic kidney disease on dialysis: The initial dose is usually 10 mcg per week, but can be adjusted by your healthcare provider.
Who Shouldn't Take Doxercalciferol?
- If you have high levels of calcium or vitamin D in your body.
- If you have severe kidney disease.
- If you are allergic to doxercalciferol.
- If you are pregnant, planning to become pregnant, or are breastfeeding (it's not known whether doxercalciferol harms the baby).
Advice From The Pharmacist
- Take this medication with meals.
- If you take a bile acid sequestrant (such as cholestyramine, or colestipol), wait at least 1 hour after taking your dose of the bile acid sequestrant before you take doxercalciferol.
- Doxercalciferol doses are individualized and will be adjusted based on your laboratory results.
- Inform your doctor if you have signs of high calcium or vitamin D levels (such as nausea, vomiting, constipation, loss of appetite, increased thirst, increased urination, weight loss, bone pain, and muscle weakness).
Side Effects of Doxercalciferol
Common Side Effects
- Nausea, vomiting, constipation, abdominal pain.
Uncommon/Severe Side Effects
- Uncommon side effects:
- Swelling of the hands, ankles, feet, face, lips, or throat.
- Rare side effects:
- chest pain, shortness of breath; fast, slow, or irregular heartbeat; and unusual tiredness.
- Severe side effects:
- Persistent loss of appetite, persistent vomiting, severe stomach or abdominal pain.
Risks and Warnings of Doxercalciferol
- Doxercalciferol may increase your risk of overabsorption of calcium (hypercalcemia) and early symptoms may include weakness, loss of appetite, nausea, vomiting, constipation, increased thirst, and urination.
- Avoid using magnesiumcontaining products (such as antacids) while taking Doxercalciferol since these can cause high magnesium levels in the blood.
Interactions with Doxercalciferol
Common Drug Interactions
- Antacids containing magnesium, calcium
- Calcipotriene
- Digoxin
- Thiazide diuretics (such as hydrochlorothiazide)
Alternatives to Doxercalciferol
- Calcitriol
- Paricalcitol
- Ergocalciferol
