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dilTIAZem HCl ER
dilTIAZem HCl ER (extended-release) is a calcium channel blocker used for the long-term management of hypertension (high blood pressure), chronic stable angina (chest pain), and certain types of arrhythmias such as atrial fibrillation. By controlling the influx of calcium ions into the heart and blood vessels, dilTIAZem HCl ER helps relax blood vessels and reduce the workload on the heart, leading to more stable blood pressure and heart rate control over a 24-hour period.
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Frequently Asked Questions
How long does it take for dilTIAZem HCl ER to work?
It may take 2 to 4 weeks to see the full effects on blood pressure, though some effects may be noticed within the first few days.
Can I stop taking dilTIAZem HCl ER abruptly?
No, you should not stop taking dilTIAZem HCl ER without consulting your healthcare provider, as stopping suddenly may worsen your condition or cause rebound effects.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember unless it is close to your next scheduled dose. Do not take an extra dose to make up for the missed one.
Can I drink alcohol while taking dilTIAZem HCl ER?
It is best to avoid or limit alcohol consumption, as alcohol can increase the risk of side effects like dizziness and low blood pressure.
Is dilTIAZem HCl ER safe for long-term use?
Yes, dilTIAZem HCl ER is commonly used for long-term management of hypertension, angina, and arrhythmias. Regular monitoring by your healthcare provider is necessary to ensure it remains effective and safe.
Comprehensive Drug Guide
How Does dilTIAZem HCl ER Work?
dilTIAZem HCl ER works by inhibiting the calcium channels in the heart and blood vessels. This leads to the relaxation of vascular smooth muscles, reducing the resistance the heart has to pump against, which lowers blood pressure. It also slows down the electrical conduction through the heart, helping to control heart rhythm in arrhythmias.
What is dilTIAZem HCl ER Used For?
- Hypertension
- Chronic stable angina
- Atrial fibrillation or flutter
- Supraventricular tachycardia (SVT)
Common Dosages
dilTIAZem HCl ER is available in the following strengths:
- 120 mg, 180 mg, 240 mg, 300 mg, 360 mg, 420 mg extended-release capsules or tablets
Typical Dosing
FDA Approved Indications
- For hypertension, the typical starting dose is 180 mg to 240 mg once daily, with the maximum dose reaching up to 360 mg to 480 mg daily, depending on the patient’s response and medical condition.
- For angina, the usual dose is 120 mg to 180 mg once daily.
- Dose adjustments are often made based on response and tolerability.
Who Shouldn't Take dilTIAZem HCl ER?
dilTIAZem HCl ER should not be used in individuals with:
- Severe hypotension
- Sick sinus syndrome or AV block without a pacemaker
- Recent heart attack with complications
- Known hypersensitivity to dilTIAZem
Advice From The Pharmacist
- Take dilTIAZem HCl ER at the same time every day, preferably in the morning, to maintain a consistent level of the medication in your system.
- Swallow the capsule or tablet whole. Do not crush or chew it, as this may cause too much of the drug to be released at once.
- If you experience symptoms like dizziness, fainting, or irregular heartbeats, contact your healthcare provider immediately.
- Avoid consuming grapefruit or grapefruit juice while taking dilTIAZem HCl ER, as it may increase the risk of side effects by raising drug levels in the blood.
Side Effects of dilTIAZem HCl ER
Common Side Effects
- Fatigue
- Dizziness
- Headache
- Swelling (edema) of the ankles, feet, or hands
- Constipation
Uncommon/Severe Side Effects
- Bradycardia (slow heart rate)
- Severe hypotension
- Worsening heart failure
- Liver problems (elevated liver enzymes)
Risks and Warnings of dilTIAZem HCl ER
Heart Failure: Patients with heart failure should be closely monitored, as dilTIAZem can worsen symptoms by reducing the heart's ability to pump blood.
Bradycardia and AV Block: dilTIAZem may cause slow heart rate or block the electrical signals in the heart, particularly in patients with existing heart conduction problems.
Hepatic Impairment: Caution is needed in patients with liver disease, as dilTIAZem is metabolized by the liver and can lead to elevated liver enzymes.
Interactions with dilTIAZem HCl ER
Common Drug Interactions
- Beta-blockers: Taking dilTIAZem HCl ER with beta-blockers (e.g., metoprolol) increases the risk of bradycardia and heart failure.
- Digoxin: dilTIAZem can increase blood levels of digoxin, leading to a higher risk of toxicity.
- CYP3A4 inhibitors: Medications like ketoconazole and clarithromycin can increase the blood levels of dilTIAZem, leading to a greater risk of side effects.
- Statins: Concurrent use with certain statins (e.g., simvastatin) can increase the risk of muscle-related side effects, such as myopathy.
Alternatives to dilTIAZem HCl ER
- Amlodipine (Norvasc): A calcium channel blocker used for hypertension and angina with fewer heart rate-related effects.
- Verapamil: Another calcium channel blocker used to manage blood pressure and arrhythmias.
- Beta-blockers (e.g., metoprolol): Often used to manage heart rate and blood pressure, especially in patients with heart disease.
- ACE inhibitors (e.g., lisinopril): Commonly prescribed to manage high blood pressure and heart failure.
