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Digitek
Digitek (digoxin) is a cardiac glycoside used to treat heart failure and atrial fibrillation, a type of irregular heartbeat. Digitek works by increasing the strength and efficiency of the heart's contractions, which improves blood flow and helps reduce symptoms of heart failure. It also slows down the heart rate, making it an effective treatment for managing irregular heart rhythms.
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Frequently Asked Questions
How long does it take for Digitek to start working?
Digitek may take several hours to days to reach its full effect, depending on the dosage and individual response. Improvement in heart failure symptoms may be seen within a week.
Can Digitek be used long-term?
Yes, Digitek is often used as a long-term medication for managing heart failure and atrial fibrillation. Regular monitoring is necessary to avoid side effects and toxicity.
What should I do if I miss a dose of Digitek?
If you miss a dose, take it as soon as you remember unless it is close to the time for your next dose. Do not double up on doses to make up for the missed one.
What are the signs of Digitek toxicity?
Signs of toxicity include nausea, vomiting, visual disturbances (such as seeing halos), confusion, and irregular heartbeats. Contact your healthcare provider immediately if these occur.
Can Digitek be taken with other heart medications?
Yes, but certain medications may interact with Digitek. Always inform your healthcare provider of all medications you are taking to avoid potential interactions and ensure safe use.
Comprehensive Drug Guide
How Does Digitek Work?
Digitek works by inhibiting the enzyme Na+/K+ ATPase in heart cells. This increases the intracellular concentration of calcium, which strengthens heart contractions. It also increases the amount of blood pumped by the heart (cardiac output) and slows the electrical conduction of the heart, helping to control abnormal heart rhythms.
What is Digitek Used For?
- Heart failure
- Atrial fibrillation
Common Dosages
Digitek is available in the following forms and strengths:
- Tablets: 125 mcg (0.125 mg), 250 mcg (0.25 mg)
- Oral solution: 0.05 mg/mL
Typical Dosing
FDA Approved Indications
- For adults, the typical dose is 125 mcg to 250 mcg once daily. Dosing may be individualized based on kidney function, age, and the severity of the condition.
- In heart failure, lower doses are often used, and regular monitoring of serum digoxin levels is necessary to avoid toxicity.
Who Shouldn't Take Digitek?
Digitek should not be used in individuals with:
- Ventricular fibrillation
- Known hypersensitivity to digoxin
- Severe renal impairment (without careful monitoring)
Advice From The Pharmacist
- Take Digitek at the same time each day to maintain steady blood levels. Avoid doubling up on doses if you miss one.
- Be aware of the signs of digoxin toxicity, which can include nausea, vomiting, visual changes (such as seeing halos), confusion, and irregular heartbeats. Contact your healthcare provider if these occur.
- Regular monitoring of kidney function and digoxin levels in the blood is essential to avoid toxicity, especially in elderly patients or those with kidney impairment.
- Do not stop taking Digitek suddenly without consulting your healthcare provider, as it may worsen heart conditions.
Side Effects of Digitek
Common Side Effects
- Nausea
- Vomiting
- Dizziness
- Headache
- Fatigue
Uncommon/Severe Side Effects
- Arrhythmias (irregular heartbeats)
- Digoxin toxicity (confusion, vision changes, irregular heartbeat)
- Low potassium levels (hypokalemia)
- Bradycardia (slow heart rate)
Risks and Warnings of Digitek
Toxicity Risk: Digoxin has a narrow therapeutic index, meaning small changes in dose or blood levels can lead to toxicity. Symptoms include nausea, vomiting, confusion, and abnormal heart rhythms. Regular blood level monitoring is required.
Electrolyte Imbalance: Low potassium or magnesium levels can increase the risk of digoxin toxicity. Patients taking diuretics or other medications affecting electrolytes should be closely monitored.
Renal Impairment: Because digoxin is cleared by the kidneys, individuals with kidney disease may require lower doses and frequent monitoring to prevent accumulation and toxicity.
Interactions with Digitek
Common Drug Interactions
- Diuretics (e.g., furosemide): Can cause low potassium, increasing the risk of digoxin toxicity.
- Calcium channel blockers (e.g., verapamil): May increase digoxin levels in the blood and lead to toxicity.
- Antibiotics (e.g., erythromycin): Can increase digoxin absorption and raise blood levels.
- Amiodarone: Can increase digoxin levels and the risk of toxicity.
Alternatives to Digitek
- Beta-blockers (e.g., metoprolol): Used to manage heart failure and atrial fibrillation, especially in patients who cannot tolerate digoxin.
- ACE inhibitors (e.g., lisinopril): Help reduce the workload on the heart and are commonly used in heart failure.
- Calcium channel blockers (e.g., diltiazem): Used to manage atrial fibrillation in some patients as an alternative to digoxin.
- Ivabradine (Corlanor): A newer medication used to treat heart failure by reducing heart rate.
