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Diclofenac Sodium ER
Diclofenac is a medication that falls under the category of nonsteroidal anti-inflammatory drugs, or NSAIDs. It is commonly used to alleviate pain, inflammation, or swelling caused by various conditions such as arthritis, gout, menstrual cramps, and migraines.
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Frequently Asked Questions
Can I take Diclofenac if I have asthma?
It's best to talk to your doctor first as diclofenac may cause asthma triggers in some individuals.
Will Diclofenac affect my blood pressure?
Although rare, diclofenac can elevate blood pressure. If you suffer from high blood pressure, make sure to monitor your levels regularly.
Can I drink alcohol while on Diclofenac?
Drinking alcohol while taking diclofenac can significantly increase the risk of gastrointestinal side effects, so it's best to limit alcohol intake.
Can I just stop taking Diclofenac all of a sudden?
Never stop taking diclofenac without consultation from your doctor. This is necessary to avoid withdrawal symptoms.
Can I take Diclofenac while pregnant?
Diclofenac should be avoided especially in the third trimester of pregnancy unless the benefits outweigh the potential risks. Always consult your healthcare provider.
Comprehensive Drug Guide
How Does Diclofenac Sodium ER Work?
Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), thus reducing prostaglandin synthesis. These prostaglandins result in inflammation, pain, and fever, so their inhibition helps alleviate these symptoms.
What is Diclofenac Sodium ER Used For?
FDA indications: Diclofenac is primarily used to reduce pain, swelling, and joint stiffness from arthritis. This helps you to perform more of your normal daily activities.
Off-label uses: It is also used to treat muscle aches, backaches, dental pain, menstrual cramps, and sports injuries.
Common Dosages
Tablets: 25mg, 50mg, 75mg
Topical Gel: 1%, 3%
Typical Dosing
FDA Approved Indications
- Arthritis: 100 to 150mg per day split into two or three doses.
- Pain: 50mg two or three times a day.
- Dysmenorrhea: 50 to 100mg a day starting as soon as cramps begin.
- Osteoarthritis (topical): Apply 2g to the affected joint four times daily.
Who Shouldn't Take Diclofenac Sodium ER?
- Those allergic to diclofenac.
- Have a history of stomach ulcers or bleeding.
- Suffer from severe heart failure.
- Have recently undergone heart surgery.
- Are in the last trimester of pregnancy.
- Have liver or kidney disease.
Advice From The Pharmacist
- Take this medication with food to prevent stomach upset.
- Don't lie down for at least ten minutes after taking diclofenac.
- Avoid exposure to sunlight or tanning beds.
- Limit alcohol and quit smoking to reduce stomach bleeding risk.
- Do not take any other drug containing NSAIDs unless your doctor directs you to do so.
- Let your doctor know if you experience persistent stomach pain, heartburn, or black stools.
Side Effects of Diclofenac Sodium ER
Common Side Effects
- Stomach upset, nausea, heartburn, dizziness
Uncommon/Severe Side Effects
- Stomach bleeding, heart attack, and stroke could occur, especially at high doses and prolonged treatment.
Risks and Warnings of Diclofenac Sodium ER
- Cardiovascular Risk: Diclofenac may increase the risk of serious and potentially fatal cardiovascular thrombotic events, such as heart attack or stroke. The risk can occur early in treatment and may increase with duration of use and in patients with pre-existing cardiovascular disease or risk factors. Diclofenac is contraindicated for the treatment of perioperative pain in coronary artery bypass graft surgery (CABG).
- Gastrointestinal Risk: Diclofenac can cause serious stomach or intestinal problems like ulcers, bleeding, or holes. The risk can happen without warning symptoms at any time during treatment and may increase with longer use of the drug. Elderly patients are at greater risk.
Interactions with Diclofenac Sodium ER
Common Drug Interactions
- Warfarin
- Aspirin
- Lithium
- Methotrexate
Alternatives to Diclofenac Sodium ER
- Ibuprofen
- Naproxen
- Meloxicam
- Celecoxib
- Aspirin
