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Diacomit

Diacomit (stiripentol) is an antiepileptic medication used to treat Dravet syndrome, a severe form of epilepsy, in children. It is typically used in combination with other antiepileptic drugs like clobazam and valproate to reduce the frequency and severity of seizures. Diacomit works by enhancing the effects of GABA, a neurotransmitter that inhibits excessive brain activity, helping to control seizures.

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Frequently Asked Questions

How long does it take for Diacomit to start working?

The effects of Diacomit in reducing seizure frequency are usually seen within 2 to 4 weeks of starting treatment, but it may take longer for full benefits.

Can Diacomit be taken with other epilepsy medications?

Yes, Diacomit is typically used in combination with other antiepileptic drugs like clobazam and valproate to enhance its seizure-reducing effects.

What should I do if I miss a dose of Diacomit?

Take the missed dose as soon as you remember, unless it is close to the time for your next dose. Do not double the dose to make up for the missed one.

Is Diacomit safe for long-term use?

Yes, Diacomit is commonly used for long-term management of seizures in children with Dravet syndrome, but regular monitoring by a healthcare provider is necessary to manage side effects and interactions.

What are the most common side effects of Diacomit?

The most common side effects include drowsiness, loss of appetite, weight loss, and nausea. It is important to report any severe or unusual side effects to your healthcare provider.

Comprehensive Drug Guide

How Does Diacomit Work?

Diacomit works by enhancing the GABAergic system in the brain, which helps to stabilize excessive neuronal activity. By increasing the effect of GABA, Diacomit reduces seizure activity. It also inhibits certain enzymes involved in the metabolism of clobazam, prolonging its antiepileptic effects.

What is Diacomit Used For?

Treatment of seizures associated with Dravet syndrome in children aged 2 years and older, used in combination with clobazam and valproate.

Common Dosages

Diacomit is available in the following forms and strengths:

Capsules: 250 mg, 500 mg
Oral powder: 250 mg, 500 mg
Tablets: 250 mg, 500 mg

Typical Dosing

FDA Approved Indications

The typical starting dose for children is 50 mg/kg/day divided into two or three doses, taken with food. The dose is gradually adjusted based on response and tolerance.

Who Shouldn't Take Diacomit?

Diacomit should not be used in individuals with:

Severe hepatic or renal impairment
Known hypersensitivity to stiripentol or any component of the formulation

Advice From The Pharmacist

Diacomit should always be taken with food to reduce gastrointestinal side effects and improve absorption.
Avoid consuming alcohol while taking Diacomit, as it may increase side effects such as drowsiness and dizziness.
Regular blood tests may be necessary to monitor liver function and levels of co-administered medications, as Diacomit can affect the metabolism of other drugs.
Store Diacomit at room temperature and protect it from light and moisture.

Side Effects of Diacomit

Common Side Effects

Drowsiness
Loss of appetite
Weight loss
Nausea and vomiting
Tremor

Uncommon/Severe Side Effects

Neutropenia (low white blood cell count)
Hepatic impairment (elevated liver enzymes)
Psychiatric symptoms (irritability, mood changes)

Risks and Warnings of Diacomit

Blood Count Monitoring: Diacomit may cause a decrease in white blood cells (neutropenia), which increases the risk of infections. Regular blood tests are recommended to monitor blood cell levels.

Liver Function: Diacomit can affect liver enzymes, especially when used with other antiepileptic drugs. Monitoring of liver function is required.

Drug Interactions: Diacomit can affect the metabolism of other antiepileptic drugs, potentially increasing the risk of toxicity or side effects. Dose adjustments of clobazam or valproate may be necessary.

Interactions with Diacomit

Common Drug Interactions

Clobazam: Diacomit can increase the levels of clobazam and its active metabolite, which may enhance its effects but also increase the risk of side effects like drowsiness.
Valproate: Caution should be used when combining Diacomit with valproate, as it may increase the risk of liver toxicity and other side effects.
CYP inhibitors: Drugs that inhibit the CYP enzymes (such as certain antifungals) may increase Diacomit levels and increase the risk of side effects.

Alternatives to Diacomit

Epidiolex (cannabidiol): Used to treat seizures associated with Dravet syndrome and other forms of epilepsy.
Topiramate (Topamax): Another antiepileptic drug that can be used for various types of seizures.
Clobazam (Onfi): A benzodiazepine often used in combination with Diacomit for Dravet syndrome.
Valproate (Depakene): Commonly used in combination with Diacomit to control seizures in Dravet syndrome.