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Di-Phen
Di-Phen is a combination medication primarily used to treat symptoms associated with allergies, hay fever, and the common cold, such as runny nose, sneezing, and watery eyes. Di-Phen is made up of diphenhydramine, an antihistamine that blocks the effects of histamine in the body, and phenylephrine, a decongestant that relieves stuffy nose symptoms by narrowing the blood vessels in the nasal passages.
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Frequently Asked Questions
How long does it take for Di-Phen to start working?
Di-Phen usually starts working within 30 minutes to an hour after taking the medication.
Can I take Di-Phen for more than 7 days?
Di-Phen should not be used for more than 7 days unless directed by a healthcare provider. Prolonged use may mask underlying conditions or cause side effects.
Is Di-Phen safe to take if I have high blood pressure?
If you have high blood pressure, consult your doctor before taking Di-Phen, as the phenylephrine component can raise blood pressure.
Can I use Di-Phen as a sleep aid?
While diphenhydramine is sometimes used as a sleep aid, Di-Phen contains phenylephrine, which may cause wakefulness in some people. It is not recommended for use solely as a sleep aid.
What should I do if I miss a dose of Di-Phen?
If you miss a dose, take it as soon as you remember. However, if it is close to your next dose, skip the missed dose and take the next one at your regular time. Do not double the dose to catch up.
Comprehensive Drug Guide
How Does Di-Phen Work?
Di-Phen works through two active ingredients:
- Diphenhydramine blocks histamine receptors, reducing allergic symptoms like itching, sneezing, and runny nose.
- Phenylephrine works as a nasal decongestant, narrowing blood vessels in the nasal passages, which helps reduce swelling and congestion.
What is Di-Phen Used For?
- Allergic rhinitis (hay fever)
- Cold symptoms (runny nose, sneezing, congestion)
- Sinus congestion (due to the decongestant phenylephrine)
Common Dosages
Di-Phen is available in the following forms and strengths:
- Tablets: Typically containing 25 mg of diphenhydramine and 10 mg of phenylephrine.
- Liquid: 12.5 mg/5 mL diphenhydramine and 2.5 mg/5 mL phenylephrine.
Typical Dosing
FDA Approved Indications
- For adults and children 12 years and older: 1 to 2 tablets every 4-6 hours as needed.
Pediatric Dosing
- For children under 12 years: Consult a healthcare provider for appropriate dosing, especially for younger children.
Who Shouldn't Take Di-Phen?
Di-Phen should not be used in individuals with:
- Known hypersensitivity to diphenhydramine, phenylephrine, or any component of the formulation
- Severe high blood pressure or coronary artery disease
- Glaucoma or urinary retention
- Use in children under 6 years of age without medical supervision
Advice From The Pharmacist
- Di-Phen may cause drowsiness due to the antihistamine diphenhydramine, so avoid driving or operating heavy machinery until you know how it affects you.
- Avoid consuming alcohol while taking Di-Phen as it may enhance the sedative effects.
- If symptoms persist for more than 7 days or worsen, discontinue use and consult your healthcare provider.
Side Effects of Di-Phen
Common Side Effects
- Drowsiness
- Dry mouth, nose, or throat
- Dizziness
- Nervousness (due to the phenylephrine)
Uncommon/Severe Side Effects
- Severe allergic reactions (hives, difficulty breathing)
- Increased blood pressure
- Severe dizziness or fast heartbeat
Risks and Warnings of Di-Phen
Sedation Risk: The diphenhydramine component can cause significant drowsiness and impair motor skills, increasing the risk of accidents.
Increased Blood Pressure: The phenylephrine component may raise blood pressure, particularly in individuals with preexisting hypertension.
Children and Elderly: Use with caution in children under 6 and the elderly, who may be more sensitive to the side effects of this medication.
Interactions with Di-Phen
Common Drug Interactions
- CNS depressants: Combining Di-Phen with alcohol, sedatives, or tranquilizers can increase the risk of excessive drowsiness.
- MAO inhibitors: Avoid using Di-Phen with monoamine oxidase inhibitors (MAOIs), as this combination can result in dangerous increases in blood pressure.
Alternatives to Di-Phen
- Loratadine (Claritin): A non-drowsy antihistamine for allergy relief.
- Cetirizine (Zyrtec): Another second-generation antihistamine with less sedative effects than diphenhydramine.
- Pseudoephedrine (Sudafed): A decongestant alternative to phenylephrine, often used for nasal congestion.
