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Pseudoephedrine HCl

Pseudoephedrine HCl is an oral decongestant used to relieve nasal congestion caused by the common cold, sinusitis, allergies, and hay fever. It works by narrowing the blood vessels in the nasal passages, reducing swelling and congestion. Pseudoephedrine is also used in combination with other medications to manage symptoms of colds and allergies. While effective, it is regulated due to its potential use in the illicit production of methamphetamine.

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Frequently Asked Questions

How quickly does Pseudoephedrine HCl work?
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Pseudoephedrine begins to relieve nasal congestion within 30 minutes of oral administration, and its effects can last for up to 4 to 6 hours.

Can I take Pseudoephedrine HCl if I have high blood pressure?
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Pseudoephedrine can raise blood pressure, so it should be used cautiously in individuals with hypertension. Consider consulting a healthcare provider before use.

Is Pseudoephedrine HCl safe for long-term use?
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No, pseudoephedrine is intended for short-term use only. Prolonged use can lead to rebound congestion and other complications. If symptoms persist for more than 7 days, consult a healthcare provider.

Can children use Pseudoephedrine HCl?
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Yes, pseudoephedrine can be used in children 6 years and older at lower doses. However, use in younger children should be closely monitored by a healthcare provider.

What should I do if I miss a dose?
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Take the missed dose as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Comprehensive Drug Guide

How Does Pseudoephedrine HCl Work?

Pseudoephedrine works by stimulating alpha-adrenergic receptors in the smooth muscle of the nasal passages, leading to vasoconstriction (narrowing of blood vessels). This reduces blood flow to the nasal mucosa, decreases swelling, and opens the nasal airways, relieving congestion.

Common Dosages

  • 30 mg tablets
  • 60 mg tablets
  • 120 mg extended-release tablets
  • 240 mg extended-release tablets

Typical Dosing

  • For adults and children over 12 years: 60 mg every 4 to 6 hours as needed, not exceeding 240 mg per day.
  • For children 6 to 12 years: 30 mg every 4 to 6 hours as needed, not exceeding 120 mg per day.


Typical Dosing

FDA Approved Indications

  • Nasal congestion associated with colds, allergies, or hay fever
  • Sinus congestion and pressure

Who Shouldn't Take Pseudoephedrine HCl?

  • Severe hypertension or coronary artery disease
  • Monoamine oxidase inhibitor (MAOI) use within the past 14 days
  • Known hypersensitivity to pseudoephedrine or similar decongestants

Advice From The Pharmacist

  • Do not exceed the recommended dosage, as high doses may cause serious side effects such as nervousness and insomnia.
  • Avoid taking pseudoephedrine close to bedtime, as it can cause restlessness and difficulty sleeping.
  • Consult your healthcare provider if symptoms persist for more than 7 days, as prolonged use may worsen congestion.
  • Monitor blood pressure if you have a history of hypertension, as pseudoephedrine may raise blood pressure.

Side Effects of Pseudoephedrine HCl

Common Side Effects

  • Nervousness
  • Insomnia
  • Dizziness
  • Increased heart rate (tachycardia)


Uncommon/Severe Side Effects

  • Severe hypertension
  • Severe allergic reactions (e.g., swelling, difficulty breathing)
  • Hallucinations (at very high doses)

Risks and Warnings of Pseudoephedrine HCl

  • Hypertension Risk: Pseudoephedrine may raise blood pressure and should be used cautiously in individuals with hypertension or heart disease.
  • Overuse: Prolonged use of pseudoephedrine can lead to rebound congestion (worsening congestion after stopping the medication).
  • Restlessness and Insomnia: Taking pseudoephedrine too late in the day can interfere with sleep.

Interactions with Pseudoephedrine HCl

Common Drug Interactions

  • MAO inhibitors: Can lead to a dangerous increase in blood pressure.
  • Beta-blockers: May reduce the effectiveness of beta-blockers and worsen hypertension.
  • Antidepressants: Certain antidepressants, like tricyclics, can enhance the cardiovascular effects of pseudoephedrine.

Alternatives to Pseudoephedrine HCl

  • Phenylephrine: A less effective over-the-counter decongestant that does not require regulation.
  • Nasal corticosteroids: Such as fluticasone, which are used to manage nasal congestion due to allergies.
  • Antihistamines: Can be combined with decongestants for allergy-related congestion relief.