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Daypro
Daypro, the brand name for oxaprozin, is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis. It works by reducing substances in the body that cause pain and inflammation. Daypro is commonly prescribed for long-term management of arthritis to help improve joint mobility and reduce pain and swelling.
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Frequently Asked Questions
What should I do if I miss a dose of Daypro?
Take the missed dose as soon as you remember, but skip it if it's close to your next dose. Do not double up on doses to make up for a missed one.
Can I take Daypro with food?
Yes, it is recommended to take Daypro with food or milk to reduce the risk of stomach upset.
How long does it take for Daypro to start working?
Daypro typically begins to reduce pain and inflammation within a few hours of the first dose, but it may take up to two weeks to notice the full effects in managing arthritis symptoms.
Can I take Daypro long-term?
While Daypro can be used long-term to manage arthritis symptoms, prolonged use of NSAIDs carries risks, including stomach ulcers, bleeding, and cardiovascular events. It’s important to use the lowest effective dose for the shortest duration necessary and have regular checkups with your healthcare provider.
Does Daypro interact with alcohol?
It is advisable to limit alcohol consumption while taking Daypro, as alcohol can increase the risk of gastrointestinal bleeding.
Comprehensive Drug Guide
How Does Daypro Work?
Daypro works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are chemicals in the body that contribute to inflammation, pain, and fever. By blocking COX enzymes, Daypro reduces the levels of prostaglandins, thus alleviating inflammation and pain in conditions like arthritis.
What is Daypro Used For?
Common Dosages
- Tablets: 600 mg
Typical Dosing
- For osteoarthritis and rheumatoid arthritis: The usual dose is 600 mg to 1200 mg once daily, depending on the patient’s response and the severity of symptoms.
Typical Dosing
FDA Approved Indications
- Treating osteoarthritis (OA)
- Treating rheumatoid arthritis (RA)
- Treating juvenile rheumatoid arthritis (in children over 6 years of age)
Off-Label Uses
Who Shouldn't Take Daypro?
- Hypersensitivity to oxaprozin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcers
- History of aspirin-sensitive asthma
- Severe kidney or liver disease
- Pregnancy in the third trimester
Advice From The Pharmacist
- Take Daypro with food or milk to minimize stomach upset.
- Avoid taking other NSAIDs (such as ibuprofen or aspirin) while using Daypro, as this can increase the risk of stomach ulcers or bleeding.
- If you experience signs of gastrointestinal bleeding (such as black, tarry stools or vomiting blood), contact your healthcare provider immediately.
- Additionally, avoid excessive alcohol consumption, as this may increase the risk of stomach bleeding.
- Regularly monitor your symptoms and consult your doctor if you do not notice improvements or experience side effects.
Side Effects of Daypro
Common Side Effects
- Upset stomach or heartburn
- Nausea
- Diarrhea or constipation
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Stomach ulcers or gastrointestinal bleeding
- High blood pressure
- Kidney or liver problems
- Allergic reactions (such as rash, swelling, or trouble breathing)
Risks and Warnings of Daypro
- Gastrointestinal Risks: Daypro may cause serious stomach or intestinal issues such as bleeding, ulcers, or perforations. The risk is higher in older adults or those with a history of GI issues.
- Cardiovascular Risks: Long-term use of NSAIDs like Daypro can increase the risk of heart attack or stroke, especially in patients with pre-existing heart conditions.
- Kidney and Liver Function: Prolonged use of Daypro may affect kidney and liver function. Regular monitoring by a healthcare provider is recommended, especially in patients with kidney or liver disease.
Interactions with Daypro
Common Drug Interactions
- Blood thinners (such as warfarin), which can increase the risk of bleeding.
- Diuretics and blood pressure medications, which may reduce their effectiveness.
- Other NSAIDs (such as ibuprofen or aspirin), which can increase the risk of gastrointestinal bleeding.
- Antidepressants (such as SSRIs or SNRIs), which may increase the risk of bleeding.
Alternatives to Daypro
- Ibuprofen (Advil, Motrin): A common NSAID used for pain relief and inflammation.
- Naproxen (Aleve): Another NSAID option for managing arthritis pain and inflammation.
- Celecoxib (Celebrex): A COX-2 selective NSAID that may be gentler on the stomach than non-selective NSAIDs like Daypro.
- Methotrexate: A disease-modifying antirheumatic drug (DMARD) often used for rheumatoid arthritis.
