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Conjupri
Conjupri is a calcium channel blocker (CCB), specifically a dihydropyridine type, used to treat high blood pressure (hypertension). The active ingredient in Conjupri is levamlodipine, which is the active enantiomer of amlodipine. It helps relax the blood vessels, making it easier for the heart to pump blood, thereby lowering blood pressure. This medication is often prescribed as part of a broader treatment plan that includes lifestyle changes like diet, exercise, and weight management to help lower the risk of cardiovascular events such as heart attack or stroke.
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Frequently Asked Questions
How long does it take for Conjupri to lower blood pressure?
Conjupri typically starts working within hours of the first dose, but it may take several weeks to see the full blood pressure-lowering effect.
Can I take Conjupri with food?
Yes, Conjupri can be taken with or without food. Taking it at the same time each day helps maintain steady levels in your system.
Is Conjupri safe for long-term use?
Yes, Conjupri is often used as a long-term medication to control blood pressure. Regular monitoring by your healthcare provider is important to ensure that it remains effective and safe over time.
What should I do if I miss a dose?
If you miss a dose of Conjupri, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can I drink alcohol while taking Conjupri?
Alcohol can lower your blood pressure and may increase the risk of side effects like dizziness. It’s best to limit alcohol intake and discuss it with your healthcare provider.
Comprehensive Drug Guide
How Does Conjupri Work?
Levamlodipine, the active ingredient in Conjupri, works by inhibiting calcium ions from entering the smooth muscle cells of the heart and blood vessels. This relaxation of the vascular smooth muscle reduces blood pressure by decreasing the resistance in the arteries, allowing blood to flow more easily. By reducing the workload on the heart, it also lowers the risk of complications related to high blood pressure, such as stroke or heart attack.
Common Dosages
- Tablets: 1.25 mg, 2.5 mg, 5 mg
Typical Dosing
- For hypertension: The usual starting dose is 2.5 mg once daily. The dose may be increased to 5 mg per day, depending on the patient's response.
- For angina: The typical dose is 5 mg once daily.
- Dosing adjustments may be required for elderly patients or those with liver impairment.
Typical Dosing
FDA Approved Indications
- Hypertension: To lower blood pressure and reduce the risk of cardiovascular events
- Chronic Stable Angina: To manage chest pain
- Vasospastic Angina (Prinzmetal’s Angina)
Who Shouldn't Take Conjupri?
- Known hypersensitivity to levamlodipine, amlodipine, or any components of the formulation
- Severe low blood pressure (hypotension)
- Cardiogenic shock or unstable heart failure
Advice From The Pharmacist
- Take Conjupri exactly as prescribed, once daily, with or without food. Try to take it at the same time each day.
- Do not suddenly stop taking Conjupri, as this may cause your blood pressure to rise quickly, increasing the risk of heart complications.
- If you miss a dose, take it as soon as you remember, but if it is close to your next dose, skip the missed dose and resume your normal schedule.
- Monitor your blood pressure regularly and report any unusual symptoms, such as dizziness or swelling, to your healthcare provider.
Side Effects of Conjupri
Common Side Effects
- Swelling (edema), especially in the ankles or feet
- Dizziness or lightheadedness
- Fatigue
- Flushing or warmth in the face
- Palpitations
Uncommon/Severe Side Effects
- Worsening of chest pain (angina)
- Irregular heartbeat
- Significant drop in blood pressure (hypotension)
- Liver dysfunction (yellowing of the skin or eyes)
Risks and Warnings of Conjupri
- Hypotension: Conjupri may cause a significant drop in blood pressure, particularly in elderly patients or those with pre-existing low blood pressure. Monitor for symptoms such as dizziness or fainting.
- Edema: Swelling in the extremities, particularly in the ankles or feet, is a common side effect of Conjupri and other calcium channel blockers. If swelling becomes severe or painful, contact your healthcare provider.
- Heart Issues: In patients with severe heart disease, sudden changes in blood pressure can exacerbate symptoms like chest pain or heart failure. Close monitoring is necessary in patients with pre-existing cardiac conditions.
Interactions with Conjupri
Common Drug Interactions
- Other Antihypertensives: Combining Conjupri with other blood pressure-lowering medications may increase the risk of hypotension.
- Grapefruit juice: Grapefruit and grapefruit juice can increase the concentration of Conjupri in the bloodstream, leading to an increased risk of side effects. It is best to avoid grapefruit products while taking this medication.
- CYP3A4 Inhibitors: Medications such as ketoconazole or certain antibiotics (like clarithromycin) may increase the levels of Conjupri, potentially causing increased side effects.
Alternatives to Conjupri
- Amlodipine (Norvasc): A widely used calcium channel blocker, similar to Conjupri, for managing high blood pressure and angina.
- Losartan (Cozaar): An angiotensin II receptor blocker (ARB) that lowers blood pressure by relaxing blood vessels.
- Lisinopril (Zestril): An ACE inhibitor used for treating high blood pressure and heart failure.
- Hydrochlorothiazide (Microzide): A thiazide diuretic often used to treat hypertension by helping the body eliminate excess fluid.
