You're not logged in. Please log in to earn stock or Bitcoin rewards on your prescription purchase.
CombiPatch
CombiPatch (estradiol/norethindrone acetate) is a transdermal patch that combines estrogen (estradiol) and progestin (norethindrone acetate). It is used to treat symptoms of menopause, such as hot flashes, vaginal dryness, and prevention of postmenopausal osteoporosis. CombiPatch provides hormone replacement therapy (HRT) to help balance the decreased hormone levels during menopause.
Rx. Enter your prescription
How would you like to get your prescription? Select an option
Pharmacy pickup
Select from 35,000 pharmacies
Free two-day delivery
Coming soon!
Find a pharmacy near you. Enter your ZIP code
Are you a member? Sign up or log in.
Members have saved
$NaN
using our savings card for instant savings.
Don't pay full retail price and miss out on potential savings. Try it now—you have nothing to lose!
NaNM
worth of Satoshi has been rewarded to our members.
Everyone who signs up enjoys the benefits of earning FREE Bitcoin with every purchase.
How much Bitcoin can you earn with CombiPatch ?
The potential for Bitcoin rewards to increase and appreciate in value is a possibility to consider, which may occur over time.
See the value of your savings today
Today's Value
1 Bitcoin = $NaN
Bitcoin (BTC)
...
USD
$NaN
Adjust Bitcoin's potential value to see how much it could be worth
Potential Value
1 Bitcoin =
Bitcoin (BTC)
...
USD
$NaN
Frequently Asked Questions
How long does it take for CombiPatch to work?
Relief from menopausal symptoms such as hot flashes may occur within a few days to a few weeks after starting CombiPatch.
Can I use CombiPatch if I’ve had a hysterectomy?
Yes, but women who have had a hysterectomy may not need the progestin component. Your healthcare provider may prescribe an estrogen-only therapy.
Can CombiPatch increase my risk of cancer?
CombiPatch may slightly increase the risk of breast and endometrial cancer, especially with long-term use. Regular screenings and monitoring are important.
What should I do if my CombiPatch falls off?
If the patch falls off, reapply it or apply a new one. Continue following your regular patch-changing schedule.
Can I use CombiPatch for osteoporosis prevention alone?
Yes, CombiPatch is approved for osteoporosis prevention, but it is usually prescribed for women who need both symptom relief and bone health support.
Comprehensive Drug Guide
How Does CombiPatch Work?
CombiPatch delivers estradiol, which replaces the estrogen that the body no longer produces after menopause, alleviating menopausal symptoms. Norethindrone acetate, a progestin, is added to reduce the risk of endometrial hyperplasia (thickening of the uterine lining) in women with a uterus, which can occur when estrogen is used alone.
Common Dosages
- Transdermal patch: Estradiol/norethindrone acetate combinations include 0.05 mg/0.14 mg per day and 0.05 mg/0.25 mg per day.
Typical Dosing
- For menopausal symptoms: Apply one CombiPatch to the lower abdomen, changing the patch twice weekly (every 3-4 days). Dosing may vary depending on symptom severity and medical history.
Typical Dosing
FDA Approved Indications
- Moderate to severe vasomotor symptoms associated with menopause (e.g., hot flashes)
- Moderate to severe vulvar and vaginal atrophy due to menopause
- Prevention of postmenopausal osteoporosis
Who Shouldn't Take CombiPatch?
- Known hypersensitivity to estradiol, norethindrone acetate, or any component of the patch.
- Undiagnosed abnormal genital bleeding.
- History of breast cancer, endometrial cancer, or other estrogen-dependent cancers.
- Active or history of blood clots, stroke, or heart attack.
Advice From The Pharmacist
- Apply the patch to a clean, dry area on the lower abdomen. Avoid applying it to the breasts or irritated skin.
- Do not cut the patch or expose it to excessive heat (e.g., heating pads).
- Rotate application sites to reduce the risk of skin irritation.
- If the patch falls off, apply a new one as soon as possible.
Side Effects of CombiPatch
Common Side Effects
- Breast tenderness
- Headache
- Nausea
- Bloating
- Skin irritation at the application site
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke
- Heart attack
- Breast or endometrial cancer
Risks and Warnings of CombiPatch
- Cardiovascular Risk: Estrogen and progestin therapies can increase the risk of heart attack, stroke, and blood clots, particularly in women who smoke or have underlying cardiovascular risk factors.
- Cancer Risk: The use of estrogen alone increases the risk of endometrial cancer. Adding progestin (as in CombiPatch) reduces this risk in women with an intact uterus.
- Gallbladder Disease: Hormone replacement therapy can increase the risk of gallbladder disease, including gallstones.
Interactions with CombiPatch
Common Drug Interactions
- CYP3A4 inhibitors (e.g., erythromycin, ketoconazole) may increase estradiol levels, leading to more pronounced side effects.
- Anticoagulants: Estrogen-containing medications may reduce the effectiveness of anticoagulants like warfarin.
- St. John’s Wort: This herbal supplement can reduce the effectiveness of hormonal therapies like CombiPatch.
Alternatives to CombiPatch
- Prempro (conjugated estrogens/medroxyprogesterone): A combination hormone replacement therapy used for menopausal symptoms and osteoporosis prevention.
- Estradiol patch (Climara): An estrogen-only patch for treating menopausal symptoms (requires progestin for women with a uterus).
- Evamist (estradiol transdermal spray): A transdermal spray for treating menopausal symptoms.
