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Climara Pro

Climara Pro is a hormone replacement therapy (HRT) patch that combines estradiol and levonorgestrel. It is used to treat symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness, and to prevent postmenopausal osteoporosis in women with an intact uterus. Estradiol, a form of estrogen, helps relieve menopausal symptoms, while levonorgestrel, a progestin, helps protect the uterine lining from overgrowth (endometrial hyperplasia) caused by estrogen. Climara Pro is a once-weekly patch applied to the skin, providing continuous hormone delivery.



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Frequently Asked Questions

How long does it take for Climara Pro to start working?
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Climara Pro may begin to relieve menopausal symptoms, such as hot flashes, within a few days to a few weeks. The timing varies by individual, and full benefits may take longer to notice.

Can I shower or swim while wearing Climara Pro?
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Yes, you can shower, bathe, and swim while wearing Climara Pro. However, avoid rubbing or scrubbing the area where the patch is applied, as this may cause it to come off.

What should I do if my Climara Pro patch falls off?
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If the patch falls off, try to reapply it to a clean, dry area. If it does not adhere properly, apply a new patch and continue with your regular patch-changing schedule.

Can I use Climara Pro if I still have my uterus?
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Yes, Climara Pro is specifically designed for women with an intact uterus. The addition of levonorgestrel helps protect the uterine lining from overgrowth, reducing the risk of endometrial cancer.

Is Climara Pro safe for long-term use?
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Long-term use of hormone replacement therapy, including Climara Pro, carries certain risks, such as an increased risk of breast cancer, heart disease, and stroke. Your healthcare provider will evaluate the benefits and risks of continuing therapy based on your individual health profile.

Comprehensive Drug Guide

How Does Climara Pro Work?

Climara Pro contains two active ingredients: estradiol and levonorgestrel. Estradiol works by replacing the estrogen that the body no longer produces after menopause, relieving menopausal symptoms such as hot flashes and vaginal dryness. Levonorgestrel is a synthetic form of progesterone that helps prevent the overgrowth of the uterine lining, reducing the risk of endometrial cancer in women who still have a uterus.



Common Dosages

  • Patch: 0.045 mg estradiol/0.015 mg levonorgestrel per day

Typical Dosing

  • For menopausal symptoms: Apply one Climara Pro patch to the lower abdomen or buttocks once a week. The patch should be replaced weekly to maintain consistent hormone levels.
  • For osteoporosis prevention: Apply one patch weekly, as directed by your healthcare provider.

Typical Dosing

FDA Approved Indications

  • Moderate to severe vasomotor symptoms (hot flashes) associated with menopause
  • Prevention of postmenopausal osteoporosis in women with an intact uterus


Advice From The Pharmacist

  • Apply Climara Pro to clean, dry, and intact skin on the lower abdomen or buttocks. Do not apply it to the breasts or areas where it may be exposed to tight clothing.
  • Rotate the application site weekly to prevent skin irritation.
  • If the patch becomes loose or falls off, reapply it or replace it with a new patch and continue with your regular schedule.
  • Avoid prolonged sun exposure or heat on the patch, as it may affect hormone release.
  • Notify your healthcare provider if you experience any unusual symptoms such as breast lumps, persistent vaginal bleeding, or severe headaches.


Side Effects of Climara Pro

Common Side Effects

  • Skin irritation at the application site
  • Breast tenderness or enlargement
  • Nausea
  • Headache
  • Abdominal bloating
  • Mood changes


Uncommon/Severe Side Effects

  • Blood clots (deep vein thrombosis, pulmonary embolism)
  • Stroke or heart attack
  • Breast or endometrial cancer
  • Severe allergic reactions (rash, swelling, difficulty breathing)


Risks and Warnings of Climara Pro

  • Cardiovascular Risks: Estrogen and progestin therapy can increase the risk of cardiovascular events, such as stroke, heart attack, and blood clots, especially in women with underlying risk factors such as smoking, high blood pressure, or high cholesterol.
  • Cancer Risks: Long-term use of hormone replacement therapy may increase the risk of breast cancer and endometrial cancer, particularly in women with a history of hormone-sensitive cancers.
  • Gallbladder Disease: Estrogen use has been associated with an increased risk of gallbladder disease. Inform your healthcare provider if you have a history of gallbladder issues.

Interactions with Climara Pro

Common Drug Interactions

  • Blood Thinners (Warfarin): Estrogen can reduce the effectiveness of anticoagulants, increasing the risk of blood clots.
  • Thyroid Hormones: Estrogens may increase thyroid-binding globulin, which can alter thyroid hormone levels in the blood. Adjustments in thyroid hormone therapy may be necessary.
  • Corticosteroids: Co-administration with corticosteroids may lead to increased effects of the corticosteroids.

Alternatives to Climara Pro

  • Estradiol Transdermal Patch (Climara): A similar transdermal patch containing only estradiol, often used for hormone replacement therapy without progestin.
  • Estrogen-Progestin Oral Therapy (Prempro): A combination of oral estrogen and progestin, used for managing menopausal symptoms and preventing osteoporosis.
  • Raloxifene (Evista): A selective estrogen receptor modulator (SERM) that helps prevent osteoporosis without the use of traditional estrogen therapy.