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Citalopram Hydrobromide
Citalopram Hydrobromide is an antidepressant medication used to treat major depressive disorder (MDD). It belongs to the class of drugs called selective serotonin reuptake inhibitors (SSRIs), which work by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that affects mood, emotions, and mental well-being. Citalopram Hydrobromide is commonly prescribed to improve mood, relieve symptoms of depression, and restore interest in daily life. It is available in tablet and liquid forms.
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Frequently Asked Questions
How long does it take for Citalopram Hydrobromide to work?
It may take 4 to 6 weeks for Citalopram to show its full effect, but some people may begin to feel improvement in their symptoms within 1 to 2 weeks.
Can I stop taking Citalopram Hydrobromide suddenly?
No, stopping Citalopram suddenly can lead to withdrawal symptoms. Consult your doctor before discontinuing the medication, and follow their instructions on how to taper the dose.
Can I drink alcohol while taking Citalopram?
It’s best to limit alcohol consumption while taking Citalopram, as it can increase the risk of side effects such as drowsiness or dizziness.
Is Citalopram Hydrobromide safe during pregnancy?
Citalopram should be used during pregnancy only if the potential benefits outweigh the risks. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
What should I do if I miss a dose of Citalopram?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Comprehensive Drug Guide
How Does Citalopram Hydrobromide Work?
Citalopram Hydrobromide works by inhibiting the reuptake of serotonin in the brain. By preventing the reabsorption of serotonin, it allows more serotonin to remain available in the brain, which helps improve mood and reduce symptoms of depression. This increase in serotonin levels can restore emotional balance and alleviate depressive thoughts.
What is Citalopram Hydrobromide Used For?
FDA Indications: Citalopram is primarily used to treat depression. It helps to improve energy levels, feelings of well-being, and appetite and decreases anxiety and insomnia related to depression.
Off-label uses: Citalopram has also been used off-label for anxiety disorders, panic disorder, obsessive-compulsive disorder (OCD), and hot flashes that happen with menopause.
Common Dosages
- Tablets: 10 mg, 20 mg, 40 mg
- Oral Solution: 10 mg/5 mL
Typical Dosing
- For major depressive disorder: The typical starting dose is 20 mg once daily, which may be increased to 40 mg daily depending on the patient’s response. The maximum recommended dose is 40 mg per day.
- For elderly patients or those with liver impairment: The maximum recommended dose is 20 mg per day.
Typical Dosing
FDA Approved Indications
- For FDA-approved indications:
- Depression: 20mg per day, with a maximum dose of 40mg per day.
Off-Label Uses
Who Shouldn't Take Citalopram Hydrobromide?
- Hypersensitivity to Citalopram or any of its components
- Concurrent use of MAO inhibitors (within 14 days of stopping an MAO inhibitor)
- Patients with known long QT syndrome or a history of heart rhythm problems
Advice From The Pharmacist
- Citalopram Hydrobromide may take 4 to 6 weeks to show its full effects in improving mood and reducing depressive symptoms.
- Take Citalopram at the same time each day, with or without food, as recommended by your doctor.
- Do not stop taking Citalopram suddenly, as this may lead to withdrawal symptoms such as dizziness, irritability, and headaches. Consult your doctor before making any changes to your medication.
- Limit alcohol consumption while taking Citalopram, as it may increase the risk of side effects such as dizziness or drowsiness.
Side Effects of Citalopram Hydrobromide
Common Side Effects
- Nausea
- Dry mouth
- Fatigue or drowsiness
- Insomnia
- Increased sweating
Uncommon/Severe Side Effects
- Suicidal thoughts or behavior (particularly in young adults under 24)
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Abnormal heart rhythm (QT prolongation)
- Serotonin syndrome (confusion, agitation, rapid heart rate, muscle stiffness)
Risks and Warnings of Citalopram Hydrobromide
- Suicidal Thoughts: Citalopram Hydrobromide, like other antidepressants, may increase the risk of suicidal thoughts or behaviors in children, adolescents, and young adults under 24. Patients should be closely monitored during the first few weeks of treatment.
- QT Prolongation: Citalopram Hydrobromide can affect heart rhythm and increase the risk of QT prolongation, especially at higher doses. Patients with a history of heart disease or electrolyte imbalances should inform their doctor.
- Serotonin Syndrome: Combining Citalopram with other medications that affect serotonin levels (such as other SSRIs, SNRIs, or MAO inhibitors) may lead to serotonin syndrome, a potentially life-threatening condition.
Interactions with Citalopram Hydrobromide
Common Drug Interactions
- MAO Inhibitors: Do not use Citalopram within 14 days of stopping an MAO inhibitor, as this can lead to dangerous drug interactions.
- NSAIDs and Blood Thinners: Citalopram may increase the risk of bleeding, especially when combined with NSAIDs, aspirin, or blood-thinning medications like warfarin.
- St. John’s Wort: Combining Citalopram with herbal supplements like St. John’s Wort can increase the risk of serotonin syndrome.
Alternatives to Citalopram Hydrobromide
- Sertraline (Zoloft): Another SSRI used to treat depression and anxiety disorders.
- Fluoxetine (Prozac): An SSRI commonly prescribed for depression, anxiety, and obsessive-compulsive disorder.
- Escitalopram (Lexapro): A similar SSRI that is used for depression and generalized anxiety disorder.
- Venlafaxine (Effexor): A serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat depression and anxiety.
