CaroSpir

CaroSpir is available in an oral suspension form with a concentration of 25 mg per 5 mL. Typical dosages are individualized based on the patient's condition and needs, but common dosing schedules include:

• Heart Failure: 12.5 mg to 25 mg daily, titrated based on patient response.
• Hypertension: 25 mg to 100 mg per day, either as a single dose or divided into two doses.
• Edema: 25 mg to 200 mg per day, depending on the severity of the condition.
• Primary Hyperaldosteronism: 100 mg to 400 mg daily in divided doses.

CaroSpir is contraindicated in patients with:

• Hyperkalemia (high potassium levels).
• Addison’s disease (a condition of adrenal insufficiency).
• Severe kidney dysfunction or inability to produce urine.
• Hypersensitivity to spironolactone or any of the components of the formulation.

Patients taking CaroSpir should be advised to:

• Use a dosing syringe or oral measuring device for accurate measurement of the liquid form. Avoid using a household spoon, as it may not provide the correct dosage.
• Monitor potassium levels regularly, as this medication can cause potassium levels to rise dangerously high (hyperkalemia).
• Avoid potassium supplements and salt substitutes containing potassium unless instructed by a healthcare provider.
• Be cautious when combining CaroSpir with other medications that affect kidney function or potassium levels, such as ACE inhibitors or NSAIDs.
• Report any symptoms of high potassium, such as muscle weakness, fatigue, or an irregular heartbeat, to their healthcare provider.

• Dizziness or lightheadedness
• Fatigue
• Nausea
• Diarrhea
• Headache

• Hyperkalemia (High Potassium Levels): Symptoms include muscle weakness, fatigue, or an irregular heartbeat.
• Kidney Dysfunction: Signs include decreased urination or swelling in the legs and ankles.
• Gynecomastia (Breast Enlargement in Males): This is a rare but possible side effect due to the hormonal effects of spironolactone.
• Serious Allergic Reactions: Such as rash, itching, or difficulty breathing.

Hyperkalemia: CaroSpir can raise potassium levels, especially in patients with kidney problems, diabetes, or those taking other potassium-sparing medications. Potassium levels should be monitored regularly, and patients should avoid high-potassium foods and supplements.

Gynecomastia: Due to its effects on hormone receptors, spironolactone may cause breast enlargement in males, especially with prolonged use.

Kidney Function: In patients with impaired kidney function, CaroSpir may worsen kidney problems or increase the risk of hyperkalemia. Regular kidney function tests are necessary.

Hormonal Effects: Spironolactone has anti-androgenic properties, which may cause menstrual irregularities in women and breast enlargement in men.

CaroSpir may interact with other medications, including:

• ACE Inhibitors/ARBs: Such as lisinopril or losartan, which may increase the risk of hyperkalemia.
• NSAIDs: Non-steroidal anti-inflammatory drugs like ibuprofen, which can affect kidney function and increase potassium levels.
• Potassium Supplements: Potassium supplements or potassium-containing salt substitutes should be avoided due to the risk of hyperkalemia.
• Diuretics: Other diuretics may either increase or decrease potassium levels, and patients should inform their healthcare provider of all medications they are taking.

Alternative treatments for conditions treated with CaroSpir include:

• Other Diuretics: Such as hydrochlorothiazide or furosemide, which may be used when potassium-sparing effects are not needed.
• Other Antihypertensive Agents: Such as ACE inhibitors, ARBs, or calcium channel blockers, which may be used in combination with or instead of diuretics.
• Eplerenone: Another potassium-sparing diuretic that may be used as an alternative to spironolactone, particularly for patients concerned about hormonal side effects.