Cardizem CD

Cardizem CD is available in extended-release capsules with the following strengths:

• 120 mg
• 180 mg
• 240 mg
• 300 mg
• 360 mg
• 420 mg

The dose is individualized based on the condition being treated and the patient’s response.

Cardizem CD is contraindicated in patients with:

• Severe hypotension (low blood pressure).
• Sick sinus syndrome or second or third-degree AV block (unless a pacemaker is present).
• Heart failure with reduced ejection fraction, may worsen the condition.
• Hypersensitivity to diltiazem or any of the components of the formulation.

Patients using Cardizem CD should be advised to:

• Take the medication at the same time every day to maintain steady levels in the bloodstream.
• Avoid grapefruit and grapefruit juice, as it can interfere with the metabolism of diltiazem, leading to higher drug levels and increased side effects.
• Monitor blood pressure regularly and be aware of symptoms of low blood pressure, such as dizziness or fainting.
• Avoid suddenly stopping the medication without consulting a healthcare provider, as this could worsen heart conditions.
• Report any signs of worsening chest pain, swelling of the legs, shortness of breath, or other unusual symptoms to their healthcare provider.

• Dizziness or lightheadedness
• Fatigue
• Headache
• Nausea
• Swelling in the hands, ankles, or feet (peripheral edema)

• Bradycardia (Slow Heart Rate): This may cause dizziness, fatigue, or fainting.
• Hypotension (Low Blood Pressure): Can cause dizziness, fainting, or blurred vision.
• Heart Failure: Symptoms include swelling of the legs, rapid weight gain, or shortness of breath.
• Liver Dysfunction: Signs include yellowing of the skin or eyes (jaundice), dark urine, or severe abdominal pain.

Bradycardia and Hypotension: Cardizem CD can cause a significant drop in heart rate and blood pressure. Patients taking other medications that affect heart rate or blood pressure, such as beta-blockers, should be monitored closely.

Heart Failure: In patients with reduced ejection fraction, Cardizem CD may worsen symptoms of heart failure, such as swelling and difficulty breathing. It should be used cautiously in these patients.

Liver Function: Diltiazem can affect liver function, and liver enzymes should be monitored periodically during long-term use.

Cardizem CD may interact with other medications, including:

• Beta-Blockers: Such as metoprolol or atenolol, which may increase the risk of bradycardia or hypotension.
• Digoxin: Cardizem CD can increase digoxin levels, leading to potential toxicity.
• Statins: Diltiazem can increase the risk of muscle damage (rhabdomyolysis) when taken with statins like simvastatin or atorvastatin.
• Grapefruit Juice: Grapefruit juice inhibits the metabolism of diltiazem, increasing drug levels and the risk of side effects.

Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.

Alternative treatments for hypertension, angina, and heart rhythm disorders include:

• Other Calcium Channel Blockers: Such as amlodipine or nifedipine, work similarly to diltiazem but may have different side effect profiles.
• Beta-blockers: Such as propranolol or carvedilol, which reduce heart rate and blood pressure.
• ACE Inhibitors: Such as lisinopril, are used to lower blood pressure and protect the heart.
• Angiotensin II Receptor Blockers (ARBs): Such as losartan or valsartan, which lower blood pressure by relaxing blood vessels.