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Camzyos
Camzyos (mavacamten) is a cardiomyopathy medication used to treat symptomatic obstructive hypertrophic cardiomyopathy (HCM), a condition in which the heart muscle becomes abnormally thick, making it harder for blood to flow out of the heart. Camzyos works by targeting and reducing the excess contractility in the heart muscle, thereby improving blood flow and reducing symptoms such as shortness of breath, chest pain, and fatigue.
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Frequently Asked Questions
How long does it take for Camzyos to start working?
Camzyos may start to relieve symptoms within a few weeks, but the full effects can take several months. Regular monitoring is essential during this period to assess its efficacy.
Can I take Camzyos with food?
Yes, Camzyos can be taken with or without food. However, avoid grapefruit and grapefruit juice as they can interfere with how the medication is metabolized.
Do I need regular monitoring while on Camzyos?
Yes, patients on Camzyos require regular echocardiograms to monitor heart function and adjust the dosage accordingly.
Can I stop taking Camzyos abruptly?
No, you should not stop taking Camzyos abruptly without consulting your doctor, as it may worsen your heart condition. Your doctor will guide you on how to safely adjust your medication if necessary.
Is Camzyos safe for long-term use?
Camzyos is considered safe for long-term use when closely monitored by a healthcare provider. Regular follow-ups are necessary to ensure the medication is working effectively and safely.
Comprehensive Drug Guide
How Does Camzyos Work?
Camzyos works by inhibiting cardiac myosin, a protein involved in muscle contraction. By modulating the activity of myosin, it reduces the excessive contraction of the heart muscle, which helps improve blood flow and alleviate symptoms in patients with hypertrophic cardiomyopathy.
Common Dosages
- Capsules: 2.5 mg, 5 mg, 10 mg, and 15 mg.
Typical Dosing
- The typical starting dose is 5 mg once daily, and the dose may be adjusted based on the patient’s response and tolerance to the treatment. Patients require regular monitoring to ensure optimal dosing and to avoid complications.
Typical Dosing
FDA Approved Indications
- Symptomatic obstructive hypertrophic cardiomyopathy (HCM) in adults, which can cause shortness of breath, chest pain, and other heart-related symptoms.
Who Shouldn't Take Camzyos?
- Severe liver impairment
- A history of hypersensitivity to mavacamten or any of its ingredients.
- Concurrent use of moderate or strong CYP2C19 or CYP3A4 inhibitors, as these can lead to dangerously high levels of Camzyos in the body.
Advice From The Pharmacist
- Regular echocardiograms are necessary to monitor heart function while on Camzyos.
- Avoid drinking grapefruit juice while taking Camzyos, as it can increase the levels of the drug in your body.
- Inform your doctor if you experience any unusual symptoms such as shortness of breath, dizziness, or palpitations.
Side Effects of Camzyos
Common Side Effects
- Dizziness
- Fatigue
- Headache
- Low blood pressure (hypotension)
Uncommon/Severe Side Effects
- Heart failure due to decreased cardiac function
- Syncope (fainting)
- Liver enzyme abnormalities
Risks and Warnings of Camzyos
- Heart failure risk: Because Camzyos reduces heart muscle contractility, it can cause heart failure in some patients if the dose is too high. Close monitoring with echocardiograms is required to prevent this.
- Drug interactions: Camzyos is metabolized by CYP2C19 and CYP3A4 enzymes, so drugs that affect these enzymes can cause dangerous levels of Camzyos in the blood.
Interactions with Camzyos
Common Drug Interactions
- CYP2C19 and CYP3A4 inhibitors (e.g., ketoconazole, fluconazole) can increase the risk of side effects by raising drug levels in the bloodstream.
- CYP2C19 and CYP3A4 inducers (e.g., rifampin, St. John’s wort) may reduce the effectiveness of Camzyos.
Alternatives to Camzyos
- Beta-blockers: These are commonly prescribed for HCM to reduce heart rate and improve symptoms.
- Calcium channel blockers: Such as verapamil, may also be used to reduce symptoms of hypertrophic cardiomyopathy.
- Disopyramide: An anti-arrhythmic drug sometimes used in HCM to reduce symptoms by reducing the strength of the heart's contractions.
