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Banzel
Banzel (rufinamide) is an anticonvulsant medication used to treat seizures associated with Lennox-Gastaut syndrome, a severe form of childhood epilepsy. Banzel helps reduce the frequency of seizures by stabilizing the electrical activity in the brain. It is typically prescribed for patients 4 years of age and older.
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Frequently Asked Questions
How long does it take for Banzel to work?
Most patients begin to see a reduction in seizures within a few days to a few weeks of starting Banzel.
Can Banzel be taken with other seizure medications?
Yes, Banzel is often used in combination with other anticonvulsants. However, your healthcare provider may need to adjust the doses of other medications.
Is Banzel safe for children?
Yes, Banzel is approved for use in children aged 4 years and older.
What should I do if I miss a dose of Banzel?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Can Banzel affect heart rhythm?
Yes, Banzel can cause QT shortening, which may affect heart rhythm. Patients with heart conditions should use Banzel with caution.
Comprehensive Drug Guide
How Does Banzel Work?
Banzel works by inhibiting sodium channels in the brain, which helps to stabilize the electrical activity that causes seizures. This action reduces the likelihood of seizures and helps control seizure frequency in patients with Lennox-Gastaut syndrome.
Common Dosages
- Oral tablets: 200 mg and 400 mg
- Oral suspension: 40 mg/mL
Typical Dosing
- For Lennox-Gastaut syndrome: The typical starting dose is 10 mg/kg/day, divided into two doses, with gradual increases every other day as needed, up to a maximum of 45 mg/kg/day.
Typical Dosing
FDA Approved Indications
- Seizures associated with Lennox-Gastaut syndrome in patients 4 years of age and older.
Who Shouldn't Take Banzel?
- Known hypersensitivity to rufinamide or any component of the formulation.
- Familial short QT syndrome, a rare heart condition.
Advice From The Pharmacist
- Take Banzel with food to improve absorption and reduce the risk of stomach upset.
- Do not stop taking Banzel abruptly, as this may increase the risk of seizures. Taper off the medication under the guidance of a healthcare provider.
- Regular blood tests may be needed to monitor liver function during treatment with Banzel.
Side Effects of Banzel
Common Side Effects
- Dizziness
- Fatigue
- Headache
- Nausea
Uncommon/Severe Side Effects
- Suicidal thoughts or behavior
- Severe allergic reactions
- Heart rhythm problems (QT shortening)
Risks and Warnings of Banzel
- Heart Issues: Banzel may cause QT shortening, which could affect heart rhythm. It is contraindicated in patients with familial short QT syndrome.
- Suicidal Thoughts: Anticonvulsant medications, including Banzel, carry a risk of suicidal thoughts and behavior. Monitor for changes in mood or behavior.
Interactions with Banzel
Common Drug Interactions
- CYP450 inducers: Medications like carbamazepine and phenobarbital can reduce the effectiveness of Banzel.
- Oral contraceptives: Banzel may reduce the effectiveness of birth control pills. Use an additional form of contraception.
Alternatives to Banzel
- Lamictal (lamotrigine): Another anticonvulsant used for seizure control in Lennox-Gastaut syndrome.
- Topamax (topiramate): An anticonvulsant used for treating seizures and preventing migraines.
- Clobazam (Onfi): A benzodiazepine used to treat seizures associated with Lennox-Gastaut syndrome.
