Auvelity

Auvelity is contraindicated in patients with a known hypersensitivity to dextromethorphan, bupropion, or any other components of the medication. It should not be used in patients with seizure disorders, as bupropion lowers the seizure threshold. Additionally, Auvelity should not be used in patients who are currently taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days, as this can lead to dangerous drug interactions. Caution is also advised in patients with a history of eating disorders, as bupropion can increase the risk of seizures in these individuals.

Patients taking Auvelity should be advised to take the medication exactly as prescribed and to avoid any abrupt discontinuation without consulting their healthcare provider. It is important to monitor for any changes in mood, behavior, or thoughts, especially during the first few weeks of treatment or when adjusting the dose. Patients should be aware of the potential for dizziness or drowsiness and should avoid driving or operating heavy machinery until they know how the medication affects them. Additionally, patients should be informed about the risk of drug interactions and the importance of reporting all other medications and supplements they are taking.

Common side effects of Auvelity include dizziness, dry mouth, headache, and nausea. Some patients may also experience increased sweating, insomnia, or anxiety.

Serious side effects can include seizures, especially in patients with a predisposition to seizures, and an increased risk of suicidal thoughts and behaviors, particularly in young adults under the age of 24. Patients should seek immediate medical attention if they experience symptoms such as severe agitation, hallucinations, or signs of an allergic reaction, such as swelling of the face, lips, or throat, or difficulty breathing.

Auvelity carries a black box warning for an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults, particularly during the initial treatment period or when the dose is adjusted. Patients and caregivers should be vigilant for any changes in mood, behavior, or thoughts of self-harm and report these to the healthcare provider immediately. There is also a risk of seizures, particularly in patients with predisposing factors, such as a history of seizures, eating disorders, or concurrent use of medications that lower the seizure threshold.

Auvelity can interact with other medications, including other antidepressants, antipsychotics, and drugs that affect the central nervous system. It should not be taken with other medications containing bupropion or dextromethorphan to avoid excessive dosing. Additionally, medications that lower the seizure threshold, such as antipsychotics, certain antibiotics, and systemic corticosteroids, should be used cautiously with Auvelity. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential interactions.

Alternative treatments for major depressive disorder include other antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs) like fluoxetine (Prozac) or sertraline (Zoloft), serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine (Effexor), or atypical antidepressants like mirtazapine (Remeron). Non-pharmacological options include psychotherapy, cognitive-behavioral therapy (CBT), and lifestyle changes such as regular exercise and stress management techniques. The choice of alternative treatment will depend on the patient’s specific symptoms, response to previous treatments, and overall health.