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Aplenzin
Aplenzin (bupropion hydrobromide) is a prescription antidepressant used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). It belongs to the aminoketone class of antidepressants, and works by affecting the balance of certain neurotransmitters in the brain, particularly dopamine and norepinephrine. Aplenzin is similar to bupropion hydrochloride (Wellbutrin), but it is designed for once-daily dosing due to its extended-release formulation.
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Frequently Asked Questions
How long does it take for Aplenzin to work?
Most patients begin to notice improvement in their mood and energy levels within 2 to 4 weeks of starting Aplenzin, but it may take up to 6 to 8 weeks for the full effect.
Can Aplenzin cause weight loss?
Yes, weight loss is a common side effect of Aplenzin, which may be more noticeable in some patients than others. If weight loss becomes significant or problematic, consult your healthcare provider.
Can I drink alcohol while taking Aplenzin?
It is best to avoid alcohol while taking Aplenzin, as it can increase the risk of seizures and exacerbate side effects like dizziness and drowsiness.
What should I do if I miss a dose of Aplenzin?
If you miss a dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once to make up for a missed dose, as this increases the risk of seizures.
Is Aplenzin safe to take during pregnancy?
Aplenzin should only be used during pregnancy if the potential benefits outweigh the risks. Always consult your healthcare provider if you are pregnant or planning to become pregnant while on Aplenzin.
Comprehensive Drug Guide
How Does Aplenzin Work?
Aplenzin works by inhibiting the reuptake of dopamine and norepinephrine, two neurotransmitters associated with mood regulation. By increasing the availability of these chemicals in the brain, Aplenzin helps improve mood and alleviate the symptoms of depression. Unlike many other antidepressants, Aplenzin does not significantly affect serotonin levels.
Common Dosages
- Extended-release tablets: 174 mg, 348 mg, 522 mg
Typical Dosing
- For major depressive disorder (MDD): The typical starting dose is 174 mg once daily, which may be increased to 348 mg once daily based on response and tolerability.
- For seasonal affective disorder (SAD): Treatment often begins in the fall with 174 mg once daily, and may be increased to 348 mg for patients who need a stronger effect. Treatment is usually discontinued in early spring.
Typical Dosing
FDA Approved Indications
- Major depressive disorder (MDD)
- Seasonal affective disorder (SAD)
Who Shouldn't Take Aplenzin?
- A known seizure disorder or a history of seizures
- Eating disorders such as anorexia nervosa or bulimia, as they increase the risk of seizures
- Abrupt discontinuation of alcohol, benzodiazepines, or other sedatives
- Known hypersensitivity to bupropion or any other components of the formulation
Advice From The Pharmacist
- Aplenzin should be taken once daily, with or without food, and should not be crushed, chewed, or broken, as this will affect the extended-release mechanism.
- Avoid alcohol while taking Aplenzin, as it may increase the risk of seizures.
- If you miss a dose, skip it and take the next dose at the usual time—do not double up.
- It may take several weeks before the full benefits of Aplenzin are felt. Continue taking it as directed by your healthcare provider.
Side Effects of Aplenzin
Common Side Effects
- Dry mouth
- Insomnia
- Weight loss
- Increased sweating
Uncommon/Severe Side Effects
- Seizures (especially at higher doses or in those with risk factors)
- Increased risk of suicidal thoughts or behavior in young adults
- High blood pressure (hypertension)
Risks and Warnings of Aplenzin
- Seizure risk: Aplenzin can increase the risk of seizures, particularly in individuals with pre-existing risk factors such as eating disorders or excessive alcohol use. The risk increases with higher doses.
- Suicidal thoughts and behaviors: As with other antidepressants, there is a risk of increased suicidal thoughts or behaviors, especially in young adults, during the initial weeks of treatment.
- Hypertension: Aplenzin can cause elevated blood pressure, so blood pressure should be monitored regularly, especially in those with pre-existing hypertension.
- Mania: Patients with bipolar disorder should be monitored, as antidepressants like Aplenzin may induce manic episodes.
Interactions with Aplenzin
Common Drug Interactions
- MAO inhibitors: Using Aplenzin with MAO inhibitors or within 14 days of discontinuation can result in dangerous drug interactions. Avoid combining these drugs.
- Alcohol: Combining Aplenzin with alcohol can increase the risk of seizures and worsen side effects such as drowsiness and dizziness.
- Other medications that lower the seizure threshold: Drugs like antipsychotics, tricyclic antidepressants, and stimulants may increase the risk of seizures when used with Aplenzin.
- Nicotine replacement therapy: Aplenzin may enhance the effects of nicotine, so patients using nicotine patches or gum should consult their doctor.
Alternatives to Aplenzin
- Wellbutrin (bupropion hydrochloride): A similar formulation of bupropion used for the same indications.
- Zoloft (sertraline): A selective serotonin reuptake inhibitor (SSRI) used for depression and anxiety disorders.
- Effexor (venlafaxine): A serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat depression and anxiety.
- Cymbalta (duloxetine): An SNRI used for depression, anxiety, and chronic pain conditions.
