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Amoxapine
Amoxapine, a type of antidepressant medication known as tetracyclic, can be used for the treatment of severe depression and bipolar disorder. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain. While it can cause side effects such as dizziness, dry mouth, and occasional weight changes, your healthcare provider will make sure the benefits outweigh any potential issues.
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Frequently Asked Questions
Can Amoxapine affect my sex drive or performance?
Yes, amoxapine can sometimes cause changes in sexual desire or performance. It's best to discuss these side effects with your healthcare provider. They may be able to adjust your dose or suggest other treatments to manage these effects.
Can I drink alcohol while taking Amoxapine?
It's best to avoid or limit alcohol since it can worsen drowsiness and dizziness caused by the medication.
Can I just stop taking Amoxapine if I start feeling better?
No, discontinuing the medication abruptly can lead to withdrawal symptoms. It's best to talk with your healthcare provider about a plan to lower your dose gradually.
Does Amoxapine make you feel tired or sleepy?
Yes, drowsiness is a common side effect. It's best to take the medication before bedtime to minimize this effect.
Comprehensive Drug Guide
How Does Amoxapine Work?
Amoxapine is a tetracyclic antidepressant drug that acts to increase the levels of certain neurotransmitters in the brain that help improve mood, relieve anxiety and tension, and increase feelings of wellbeing.
What is Amoxapine Used For?
FDA indications: Amoxapine is used to treat symptoms of depression, anxiety, and bipolar disorder.
Offlabel uses: It's also been used for the offlabel treatment of insomnia, obsessivecompulsive disorder, and panic disorder.
Common Dosages
Tablets: 25mg, 50mg, 100mg, 150mg
Typical Dosing
FDA Approved Indications
- Depression and anxiety: The starting dose of 50mg two or three times a day, can be increased to 300mg per day as divided doses.
- Bipolar disorder: Dosage will be determined by the healthcare provider.
Off-Label Uses
- Insomnia, obsessivecompulsive disorder, and panic disorder: Dosage will be determined by the healthcare provider.
Who Shouldn't Take Amoxapine?
- Have a hypersensitivity to amoxapine or any other tetracyclic antidepressants.
- Are about to undergo elective surgery.
- Are suffering from alcohol withdrawal.
- Have heart disease.
- Are breastfeeding or are planning to. It's not known whether amoxapine harms the baby.
- Are taking MAO inhibitors.
Advice From The Pharmacist
- Maintaining a regular eating, drinking, and exercise routine can help manage any potential side effects.
- As this medication can make you drowsy, avoid driving or using machinery until you can do it safely.
- Limit the consumption of alcohol as it may increase dizziness or drowsiness.
- Inform your healthcare provider if the symptoms persist or worsen.
Side Effects of Amoxapine
Common Side Effects
- Dry mouth, constipation
- Drowsiness, dizziness
- Increased appetite, weight gain
Uncommon/Severe Side Effects
- Uncommon side effects:
- Changes in sexual desire or ability
- Swelling of the breasts in men, discharge from nipples
- Rare side effects:
- Tardive dyskinesia: a movement disorder that can be irreversible.
- Restlessness, agitation
- High fever, muscle stiffness
- Severe side effects
- Changes in heart rhythm
- Severe allergic reactions: rash, itching, swelling, severe dizziness, trouble breathing
Risks and Warnings of Amoxapine
- Amoxapine can enhance suicidal thoughts, especially in individuals under the age of 24. Regular communication and monitoring are vital if these symptoms emerge.
- Withdrawal symptoms like nausea, headache, and fatigue may appear if stopped abruptly. Tapering off under the direction of a healthcare provider is often recommended.
- Pregnant women and those planning to conceive should use caution.
- Individuals with heart conditions, seizures, and glaucoma should refrain from using amoxapine or use caution.
Interactions with Amoxapine
Common Drug Interactions
- Warfarin
- Cimetidine
- Carbamazepine
- Barbiturates
- Nicotine
- Alcohol
Alternatives to Amoxapine
- Fluoxetine
- Sertraline
- Paroxetine
- Citalopram
- Imipramine
