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amLODIPine Besylate
amLODIPine Besylate is a calcium channel blocker commonly prescribed for the treatment of high blood pressure (hypertension) and angina (chest pain). It works by relaxing blood vessels, allowing blood to flow more easily, which helps lower blood pressure and reduce the heart's workload. amLODIPine Besylate is also used to prevent certain types of chest pain (angina) and improve exercise tolerance in patients with cardiovascular conditions.
Drug Availability and Controlled Substance Status
amLODIPine Besylate is available in oral tablet form, with strengths of 2.5 mg, 5 mg, and 10 mg. It is not classified as a controlled substance, making it available with a prescription without the regulatory restrictions that apply to controlled drugs.
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Frequently Asked Questions
Can amLODIPine Besylate be taken with other blood pressure medications?
Yes, amLODIPine Besylate can be used in combination with other antihypertensive medications. However, careful monitoring of blood pressure is necessary, and dose adjustments may be required.
How should amLODIPine Besylate be stored?
Store amLODIPine Besylate at room temperature, away from moisture and light. Ensure that it is kept out of reach of children and pets.
Is amLODIPine Besylate safe during pregnancy?
amLODIPine is generally not recommended during pregnancy due to limited data on its safety. Alternative treatments should be considered. Consult your healthcare provider for advice.
What should I do if I miss a dose of amLODIPine Besylate?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double up on doses to make up for a missed one.
Comprehensive Drug Guide
How Does amLODIPine Besylate Work?
amLODIPine Besylate works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in the relaxation of blood vessels (vasodilation). This action lowers blood pressure by reducing the resistance in the arteries, making it easier for the heart to pump blood. Additionally, by relaxing the coronary arteries, amLODIPine improves oxygen supply to the heart, helping to prevent angina.
Common Dosages
amLODIPine Besylate is commonly available in the following dosages:
- 2.5 mg tablets
- 5 mg tablets
- 10 mg tablets
Typical Dosing
The typical dosing for amLODIPine Besylate is:
- Adults: Start with 5 mg once daily. The dosage may be adjusted based on the patient’s response, with a maximum dose of 10 mg per day.
- Elderly: A lower starting dose of 2.5 mg once daily may be recommended for elderly patients or those with liver impairment.
Typical Dosing
FDA Approved Indications
amLODIPine Besylate is FDA-approved for the treatment of:
- Hypertension (high blood pressure)
- Chronic stable angina (chest pain)
- Vasospastic angina (Prinzmetal's angina)
Off-Label Uses
There are no widely recognized off-label uses for amLODIPine Besylate.
Who Shouldn't Take amLODIPine Besylate?
amLODIPine Besylate should not be used in patients with:
- Severe hypotension (low blood pressure)
- Known hypersensitivity to amlodipine or any of the components of the drug
- Cardiogenic shock
- Unstable angina (acute episodes)
Advice From The Pharmacist
Patients taking amLODIPine Besylate should:
- Take the medication as prescribed, typically once daily, with or without food.
- Monitor blood pressure regularly and report any significant changes to their healthcare provider.
- Avoid excessive alcohol consumption, as it can lower blood pressure further and increase the risk of side effects such as dizziness or fainting.
- Be aware of potential side effects such as dizziness or swelling in the ankles and lower legs, and contact their healthcare provider if these symptoms occur.
Side Effects of amLODIPine Besylate
Common Side Effects
Common side effects of amLODIPine Besylate include:
- Dizziness
- Swelling (edema) in the legs and ankles
- Fatigue
- Flushing (warmth, redness, or tingling sensation)
- Nausea
Uncommon/Severe Side Effects
Serious side effects may include:
- Severe hypotension (low blood pressure)
- Worsening chest pain or heart attack (in rare cases, particularly when starting the medication)
- Liver dysfunction (e.g., jaundice, elevated liver enzymes)
Risks and Warnings of amLODIPine Besylate
Major risks and warnings associated with amLODIPine Besylate include:
- Hypotension: amLODIPine can cause a significant drop in blood pressure, especially in patients who are volume-depleted or taking other antihypertensive medications. Patients should be monitored for signs of low blood pressure, such as dizziness or fainting.
- Worsening Angina: In rare cases, starting amLODIPine can cause worsening of chest pain or lead to a heart attack, particularly in patients with severe coronary artery disease. Immediate medical attention is required if this occurs.
- Hepatotoxicity: Liver function tests should be monitored periodically in patients taking amLODIPine, especially if symptoms of liver dysfunction develop.
Interactions with amLODIPine Besylate
Common Drug Interactions
amLODIPine Besylate may interact with:
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): May increase amlodipine levels, leading to enhanced effects and increased risk of side effects.
- Beta-blockers: May increase the risk of hypotension or bradycardia (slow heart rate).
- Grapefruit juice: Can increase the concentration of amlodipine in the blood, potentially leading to toxicity.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential drug interactions.
Alternatives to amLODIPine Besylate
Alternative medications to amLODIPine Besylate include:
- Lisinopril: An ACE inhibitor used to treat high blood pressure and heart failure.
- Losartan: An angiotensin II receptor blocker (ARB) used for hypertension and kidney protection in diabetic patients.
- Hydrochlorothiazide (HCTZ): A thiazide diuretic used to lower blood pressure by reducing fluid retention.
