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Ameluz

Ameluz (generic name: aminolevulinic acid hydrochloride) is a topical photosensitizing agent used in photodynamic therapy (PDT) for the treatment of actinic keratosis (a precancerous skin condition caused by sun exposure). It is also used for superficial basal cell carcinoma and field cancerization, which refers to areas of skin with multiple precancerous lesions. Ameluz works by increasing sensitivity to light, allowing light therapy to target and destroy abnormal skin cells while minimizing damage to surrounding healthy tissue.



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Frequently Asked Questions

How long does it take for the skin to heal after Ameluz treatment?
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Most patients experience redness, swelling, and peeling in the treated area, which typically resolves within 7 to 10 days after treatment.

Can I go outside after Ameluz treatment?
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It is important to avoid direct sunlight and bright indoor light for 48 hours after treatment, as the skin will be very sensitive to light during this period. If you must go outside, use sunscreen and protective clothing.

How many treatments of Ameluz will I need?
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The number of treatments required depends on the severity of your condition. Some patients may need multiple sessions spaced a few weeks apart to achieve optimal results.

Is Ameluz painful?
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During the light exposure phase of the treatment, some patients experience a burning or stinging sensation. This discomfort usually subsides after the treatment is complete, but pain management options may be discussed with your healthcare provider.

Can Ameluz be used for other skin cancers?
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Ameluz is approved for actinic keratosis and superficial basal cell carcinoma. It is not typically used for deeper or more aggressive skin cancers, such as squamous cell carcinoma or melanoma.

Comprehensive Drug Guide

How Does Ameluz Work?

Ameluz contains aminolevulinic acid (ALA), which, when applied to the skin, is converted into protoporphyrin IX, a light-sensitive compound. When exposed to a specific wavelength of light, protoporphyrin IX produces reactive oxygen species that destroy abnormal cells. This process helps eliminate actinic keratosis lesions and superficial skin cancers while preserving the surrounding healthy tissue.



Common Dosages

  • Topical gel: 10% aminolevulinic acid hydrochloride

Typical Dosing

  • Ameluz is applied by a healthcare provider during photodynamic therapy. The gel is applied to the affected area, left to absorb for approximately 3 hours, and then exposed to a light source, typically red light at a wavelength of 630 nm. The entire session lasts around 15-20 minutes after light exposure, depending on the size and location of the lesions.
  • Treatments may be repeated as necessary, depending on the severity of the condition and the patient’s response.


Typical Dosing

FDA Approved Indications

  • Treatment of actinic keratosis on the face and scalp in adults.
  • Treatment of superficial basal cell carcinoma (sBCC) in adults who are not candidates for surgery or other local therapies.


Who Shouldn't Take Ameluz?

  • Allergy to aminolevulinic acid hydrochloride or any other component of the formulation.
  • Porphyria (a rare genetic disorder affecting the production of hemoglobin).
  • Patients who are sensitive to light or have photosensitivity disorders.


Advice From The Pharmacist

  • After treatment, the skin may be sensitive to sunlight and bright indoor light for 48 hours. Patients should avoid sunlight and wear protective clothing and sunscreen during this time.
  • Side effects such as redness, swelling, or peeling at the treatment site are common and should subside within a few days. If severe pain or irritation occurs, contact your healthcare provider.
  • Keep the treated area clean and dry until the skin has healed, and avoid applying any lotions or cosmetics unless advised by your doctor.


Side Effects of Ameluz

Common Side Effects

  • Redness and swelling at the treatment site
  • Itching or burning sensation
  • Skin peeling
  • Light sensitivity in the treated area


Uncommon/Severe Side Effects

  • Severe pain or blistering at the treatment site
  • Allergic reactions (such as rash, swelling, or difficulty breathing)


Risks and Warnings of Ameluz

  • Photosensitivity: Ameluz makes the skin extremely sensitive to light, especially within the first 48 hours after treatment. Strict sun avoidance and protective measures should be followed during this time.
  • Skin Reactions: Temporary redness, irritation, or peeling of the skin is common. In rare cases, the skin reaction can be more severe, requiring medical attention.


Interactions with Ameluz

Common Drug Interactions

  • Photosensitizing medications: If you are taking other medications that increase sensitivity to light (such as tetracycline antibiotics, sulfonamides, or thiazide diuretics), there may be an increased risk of skin reactions during or after photodynamic therapy.


Alternatives to Ameluz

  • Levulan Kerastick (aminolevulinic acid): Another topical photosensitizer used in combination with blue light for the treatment of actinic keratosis.
  • Efudex (fluorouracil): A topical chemotherapy cream used for actinic keratosis and superficial basal cell carcinoma.
  • Imiquimod (Aldara): A topical immune response modifier used for actinic keratosis and superficial basal cell carcinoma.