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Alyq
Alyq (generic name: tadalafil) is a phosphodiesterase type 5 (PDE5) inhibitor used to treat pulmonary arterial hypertension (PAH). It works by relaxing the blood vessels in the lungs, reducing the workload on the heart, and allowing blood to flow more easily. Alyq is typically prescribed to improve exercise ability and reduce the progression of symptoms in patients with PAH. It is structurally similar to tadalafil marketed for erectile dysfunction but is specifically used for pulmonary hypertension.
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Frequently Asked Questions
How long does it take for Alyq to start working?
Alyq may begin improving symptoms like exercise tolerance within a few weeks, but it may take up to several months to see the full benefits.
Can I take Alyq for erectile dysfunction?
Alyq is specifically formulated and prescribed for pulmonary arterial hypertension. While it shares the same active ingredient as some erectile dysfunction medications, it is not intended for that use.
What should I do if I miss a dose of Alyq?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Is it safe to drink alcohol while taking Alyq?
Limit alcohol consumption while taking Alyq, as alcohol can increase the risk of low blood pressure and dizziness.
Can Alyq be taken with food?
Yes, Alyq can be taken with or without food. Taking it with food may help reduce the likelihood of stomach upset.
Comprehensive Drug Guide
How Does Alyq Work?
Alyq works by inhibiting phosphodiesterase type 5 (PDE5), an enzyme found in the walls of blood vessels in the lungs. By blocking PDE5, Alyq increases the levels of cyclic guanosine monophosphate (cGMP), which helps relax and dilate the pulmonary arteries, improving blood flow and reducing pulmonary blood pressure. This mechanism reduces the strain on the heart and allows patients with PAH to engage in physical activities more easily.
Common Dosages
- Tablets: 20 mg
Typical Dosing
- The usual dose of Alyq for PAH is 40 mg (two 20 mg tablets) once daily, with or without food. The dose should not be adjusted unless directed by a healthcare provider, and patients should avoid taking more than the recommended dose.
Typical Dosing
FDA Approved Indications
- The treatment of pulmonary arterial hypertension (PAH) to improve exercise ability and delay disease progression.
Who Shouldn't Take Alyq?
- Severe liver impairment
- Use of nitrates for chest pain, as this combination can cause a dangerous drop in blood pressure
- Severe hypotension (low blood pressure)
Advice From The Pharmacist
- Take Alyq at the same time each day to maintain steady blood levels.
- Avoid using grapefruit or grapefruit juice, as it can affect the metabolism of tadalafil, potentially increasing the risk of side effects.
- If you experience symptoms like dizziness, fainting, or severe shortness of breath, contact your healthcare provider immediately.
- Do not take Alyq if you are also using nitrate medications, as this combination can cause a life-threatening drop in blood pressure.
Side Effects of Alyq
Common Side Effects
- Headache
- Flushing
- Indigestion
- Back pain
- Muscle aches
Uncommon/Severe Side Effects
- Sudden vision or hearing loss
- Chest pain or irregular heartbeat
- Severe allergic reactions (such as swelling of the face or difficulty breathing)
Risks and Warnings of Alyq
- Hypotension: Alyq can cause a significant drop in blood pressure, especially when used with nitrates or certain other medications. Patients with pre-existing hypotension should use this medication with caution.
- Vision and Hearing Loss: In rare cases, Alyq has been associated with sudden vision or hearing loss. Patients experiencing these symptoms should discontinue use and seek medical attention immediately.
- Priapism: While rare, tadalafil can cause prolonged erections lasting more than four hours (priapism). Patients experiencing this side effect should seek medical help to avoid permanent damage.
Interactions with Alyq
Common Drug Interactions
- Nitrates: The use of Alyq with nitrate medications, such as nitroglycerin, is contraindicated due to the risk of severe hypotension.
- Alpha-blockers: These medications, used to treat high blood pressure and prostate conditions, may also cause an excessive drop in blood pressure when used with Alyq.
- CYP3A4 inhibitors: Drugs like ketoconazole or ritonavir can increase blood levels of Alyq, raising the risk of side effects.
Alternatives to Alyq
- Adcirca (tadalafil): Another brand of tadalafil used for PAH, identical in function to Alyq.
- Revatio (sildenafil): A PDE5 inhibitor used for the same purpose as Alyq but with a different active ingredient.
- Opsumit (macitentan): A different type of medication for PAH that targets the endothelin pathway to reduce blood pressure in the lungs.
