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Revatio
Revatio (sildenafil) is a medication primarily used for the treatment of pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the blood vessels that supply the lungs. It helps improve exercise capacity and decrease symptoms associated with this condition. Revatio works by relaxing the blood vessels in the lungs, which allows for better blood flow and reduced pressure.
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Frequently Asked Questions
How quickly does Revatio start to work?
Patients may begin to notice improvements in symptoms of pulmonary arterial hypertension within a few weeks, but it may take longer to assess the full therapeutic effect.
Can I stop taking Revatio suddenly?
It is advisable to consult your healthcare provider before discontinuing Revatio, as this may affect the management of PAH.
Are there any specific dietary restrictions while using Revatio?
There are no specific dietary restrictions associated with Revatio; however, patients should discuss any concerns with their healthcare provider.
What should I do if I miss a dose of Revatio?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Revatio safe for long-term use?
Revatio is generally considered safe for long-term use in managing pulmonary arterial hypertension, but regular follow-up appointments are essential to monitor for efficacy and any potential side effects.
Comprehensive Drug Guide
How Does Revatio Work?
Sildenafil, the active ingredient in Revatio, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This inhibition increases levels of cyclic guanosine monophosphate (cGMP), leading to relaxation of smooth muscle and vasodilation in the pulmonary vasculature. This effect lowers pulmonary blood pressure and improves blood flow, which helps alleviate the symptoms of PAH.
What is Revatio Used For?
Common Dosages
- Tablets: Common strengths include 20 mg, 40 mg, and 60 mg.
- Oral suspension: 10 mg/mL.
Typical Dosing
- The usual recommended dose for adults is 20 mg taken three times a day, approximately 4 to 6 hours apart. Dosing may be adjusted based on individual response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of pulmonary arterial hypertension (PAH) to improve exercise capacity in patients.
Who Shouldn't Take Revatio?
- Known hypersensitivity to sildenafil or any components of the formulation.
- Concurrent use of nitrates or nitric oxide donors, as this can lead to severe hypotension.
- Severe cardiovascular conditions or unstable angina.
Advice From The Pharmacist
- Instruct patients to take Revatio as prescribed and to adhere to the dosing schedule for optimal efficacy.
- Advise patients about potential side effects, such as headaches, flushing, or gastrointestinal disturbances, and encourage them to report any severe or persistent symptoms.
- Discuss the importance of monitoring blood pressure and recognizing signs of worsening PAH symptoms.
Side Effects of Revatio
Common Side Effects
- Headache
- Flushing
- Nasal congestion
- Diarrhea
- Dizziness
Uncommon/Severe Side Effects
- Severe hypotension
- Priapism (prolonged erection)
- Vision changes or loss (rarely).
Risks and Warnings of Revatio
- Cardiovascular Risks: Patients with pre-existing cardiovascular conditions should be monitored closely, as sildenafil can cause changes in blood pressure.
- Drug Interactions: Caution is advised when using Revatio with other medications that can affect blood pressure or other PDE5 inhibitors.
Interactions with Revatio
Common Drug Interactions
- Nitrates: The use of nitrates or nitric oxide donors with Revatio can lead to significant hypotension.
- Other Antihypertensives: Patients should inform their healthcare provider of all medications they are taking, especially antihypertensive agents, to avoid potential interactions.
Alternatives to Revatio
- Other PAH Treatments: Alternatives may include other medications used to treat pulmonary arterial hypertension, such as bosentan (an endothelin receptor antagonist) or treprostinil (a prostacyclin analog).
