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Altace
Altace (generic name: ramipril) is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension) and congestive heart failure. It is also prescribed to reduce the risk of heart attack or stroke in high-risk patients, such as those with a history of cardiovascular disease. By lowering blood pressure, Altace helps reduce strain on the heart and blood vessels, preventing complications like heart failure and kidney disease.
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Frequently Asked Questions
How long does it take for Altace to lower blood pressure?
Altace may begin to lower blood pressure within a few hours of the first dose, but it can take 2-4 weeks of consistent use to achieve full blood pressure-lowering effects.
Can I take Altace if I am pregnant?
No, Altace should not be taken during pregnancy. It can harm the unborn baby, especially in the second and third trimesters.
Can Altace cause a cough?
Yes, a persistent dry cough is a common side effect of ACE inhibitors like Altace. If the cough is bothersome, your healthcare provider may suggest switching to an alternative medication.
What should I do if I miss a dose of Altace?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Can Altace be used with other blood pressure medications?
Yes, Altace can be used with other antihypertensive medications, such as diuretics or beta-blockers, but your healthcare provider will monitor your treatment closely to avoid any potential interactions.
Comprehensive Drug Guide
How Does Altace Work?
Altace works by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for the production of angiotensin II, a chemical that causes blood vessels to narrow and raises blood pressure. By blocking this enzyme, Altace relaxes blood vessels, lowering blood pressure and making it easier for the heart to pump blood. This helps to reduce the workload on the heart and can slow the progression of heart failure.
What is Altace Used For?
Common Dosages
- Capsules: 1.25 mg, 2.5 mg, 5 mg, and 10 mg
Typical Dosing
- For hypertension: The usual starting dose is 2.5 mg to 5 mg once daily, with adjustments based on the patient’s response. The maximum daily dose is 20 mg.
- For heart failure: The typical dose is 2.5 mg twice daily, which may be adjusted according to the patient's condition.
Typical Dosing
FDA Approved Indications
- Treatment of hypertension (high blood pressure)
- Reduction of the risk of heart attack, stroke, and cardiovascular mortality in patients at high risk, such as those with a history of heart disease or diabetes
- Treatment of congestive heart failure following a heart attack
Who Shouldn't Take Altace?
- History of angioedema related to previous ACE inhibitor use
- Pregnancy, as ACE inhibitors can harm or cause death to an unborn baby
- Severe kidney impairment or dialysis
- Allergy to ramipril or other ACE inhibitors
Advice From The Pharmacist
- Take Altace at the same time each day, with or without food.
- It’s important to drink plenty of fluids, as dehydration can increase the risk of side effects such as low blood pressure or kidney problems.
- Avoid potassium supplements or potassium-rich foods, as Altace can increase potassium levels in the blood, leading to hyperkalemia.
- Notify your healthcare provider if you experience symptoms like swelling of the face, lips, or throat, as this may indicate angioedema, a serious side effect.
Side Effects of Altace
Common Side Effects
- Dizziness or lightheadedness
- Cough (a common side effect of ACE inhibitors)
- Fatigue
- Nausea
Uncommon/Severe Side Effects
- Angioedema (swelling of the face, lips, or throat)
- Hyperkalemia (high potassium levels)
- Kidney dysfunction or failure
Risks and Warnings of Altace
- Angioedema: Altace can cause a potentially life-threatening allergic reaction called angioedema, which can result in swelling of the face, throat, or extremities. This requires immediate medical attention.
- Pregnancy Risk: Altace should not be used during pregnancy, especially in the second and third trimesters, as it can cause injury or death to the fetus.
- Kidney Function: Regular kidney function tests may be required, as ACE inhibitors can affect kidney health, especially in patients with pre-existing kidney conditions.
Interactions with Altace
Common Drug Interactions
- Potassium supplements and diuretics: Combining Altace with potassium supplements or potassium-sparing diuretics (such as spironolactone) may lead to dangerous levels of potassium in the blood.
- NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can reduce the effectiveness of Altace and increase the risk of kidney damage.
- Diuretics: Using Altace with diuretics (water pills) may lead to a significant drop in blood pressure.
Alternatives to Altace
- Lisinopril: Another ACE inhibitor used for high blood pressure and heart failure.
- Losartan (Cozaar): An angiotensin receptor blocker (ARB) often used when patients cannot tolerate ACE inhibitors due to side effects like cough.
- Amlodipine (Norvasc): A calcium channel blocker used to treat high blood pressure and chest pain (angina).
- Hydrochlorothiazide (HCTZ): A diuretic used to treat high blood pressure and fluid retention.
