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Allzital
Allzital is a combination medication that contains butalbital, a barbiturate, and acetaminophen, an analgesic and antipyretic. It is primarily prescribed for the treatment of tension headaches. Butalbital works as a sedative, helping to relax muscle contractions involved in tension headaches, while acetaminophen relieves pain and reduces fever. This combination is designed to provide relief from the pain and discomfort associated with tension headaches.
Drug Availability and Controlled Substance Status
Allzital is available in oral tablet form, typically containing 25 mg of butalbital and 325 mg of acetaminophen. Allzital is classified as a Schedule III controlled substance in the United States due to the presence of butalbital, which has a potential for abuse and dependence.
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Frequently Asked Questions
Can Allzital be used for migraine headaches?
Allzital is not specifically approved for migraines but may be prescribed off-label for this use. Consult your healthcare provider for guidance on the appropriate treatment for migraines.
How should Allzital be stored?
Store Allzital at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets.
What should I do if I miss a dose of Allzital?
If you miss a dose and still have a headache, take the dose as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed one.
Is it safe to stop taking Allzital abruptly?
Due to the risk of withdrawal symptoms from butalbital, Allzital should not be stopped abruptly if taken regularly for an extended period. Consult your healthcare provider for a safe discontinuation plan.
Comprehensive Drug Guide
How Does Allzital Work?
Allzital works through the combined effects of its two active ingredients. Butalbital is a barbiturate that depresses the central nervous system (CNS), providing sedative and muscle-relaxing effects. Acetaminophen is an analgesic that reduces pain by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. Together, these actions help to alleviate the symptoms of tension headaches.
Common Dosages
Allzital is commonly available in the following dosage:
- Tablets containing 25 mg of butalbital and 325 mg of acetaminophen
Typical Dosing
The typical dosing for Allzital is:
- Adults: 1 to 2 tablets every 4 hours as needed for pain relief. The maximum daily dose should not exceed 6 tablets in a 24-hour period.
Note: Due to the risk of dependence and overuse, Allzital should be used for the shortest duration possible, and long-term use should be avoided.
Typical Dosing
FDA Approved Indications
Allzital is FDA-approved for the treatment of:
- Tension headaches (muscle contraction headaches)
Off-Label Uses
There are no widely recognized off-label uses for Allzital.
Who Shouldn't Take Allzital?
Allzital should not be used in patients with:
- Hypersensitivity to butalbital, acetaminophen, or any of the components of the drug
- Severe liver impairment or liver disease (due to the acetaminophen component)
- Porphyria (a rare genetic disorder affecting the skin and nervous system)
- A history of drug or alcohol addiction
Advice From The Pharmacist
Patients taking Allzital should:
- Take the medication exactly as prescribed and avoid exceeding the recommended dosage due to the risk of liver damage from acetaminophen and dependence from butalbital.
- Avoid alcohol while taking Allzital, as it can increase the risk of liver damage and enhance the sedative effects of butalbital.
- Be aware of the potential for drowsiness and avoid driving or operating heavy machinery until they know how the medication affects them.
- Inform their healthcare provider of all other medications they are taking to avoid potential drug interactions.
Side Effects of Allzital
Common Side Effects
Common side effects of Allzital include:
- Drowsiness
- Dizziness
- Nausea
- Vomiting
Uncommon/Severe Side Effects
Serious side effects may include:
- Liver damage (from acetaminophen)
- Respiratory depression (from butalbital)
- Dependence and withdrawal symptoms (from butalbital)
- Allergic reactions (e.g., rash, swelling, difficulty breathing)
Risks and Warnings of Allzital
Major risks and warnings associated with Allzital include:
- Hepatotoxicity: Acetaminophen can cause severe liver damage, especially with excessive use or in combination with alcohol. Patients should be cautious about using other acetaminophen-containing products.
- Dependence and Withdrawal: Butalbital has the potential for abuse, dependence, and withdrawal symptoms. Use should be limited to short-term treatment, and discontinuation should be gradual under medical supervision.
- CNS Depression: Butalbital can cause significant CNS depression, leading to drowsiness, impaired coordination, and slowed breathing, particularly when combined with other CNS depressants (e.g., alcohol, opioids).
Interactions with Allzital
Common Drug Interactions
Allzital may interact with:
- Alcohol: Increases the risk of liver damage and enhances CNS depression.
- Opioids and Benzodiazepines: Increased risk of severe sedation, respiratory depression, and overdose.
- Warfarin: Acetaminophen may increase the anticoagulant effects of warfarin, increasing the risk of bleeding.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential drug interactions.
Alternatives to Allzital
Alternative medications to Allzital include:
- Fioricet: Another combination of butalbital, acetaminophen, and caffeine for tension headaches.
- Aspirin-Butalbital (Fiorinal): A combination of butalbital, aspirin, and caffeine used for tension headaches.
- NSAIDs (e.g., ibuprofen, naproxen): Non-steroidal anti-inflammatory drugs that may be used for tension headaches in patients who cannot take barbiturates.
