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Alfuzosin HCl ER

Alfuzosin HCl ER is the generic version of Uroxatral. It is prescribed for the treatment of benign prostatic hyperplasia (BPH), a condition that affects the prostate gland in men and causes urinary difficulties. Alfuzosin belongs to the drug class of alpha-blockers, which help relax the muscles in the prostate and bladder neck, making it easier to urinate and relieving symptoms of BPH.


Drug Availability and Controlled Substance Status


Alfuzosin HCl ER is available in extended-release (ER) oral tablet form, typically in a strength of 10 mg. It is not classified as a controlled substance, making it available with a prescription without the stringent regulations that apply to controlled medications.



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Frequently Asked Questions

Can Alfuzosin HCl ER be taken with food?
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Yes, Alfuzosin should be taken with food, preferably after the same meal each day, to improve absorption and reduce the risk of side effects.

How long does it take for Alfuzosin HCl ER to start working?
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Alfuzosin may begin to improve urinary symptoms within a few days, but it may take several weeks to achieve the full therapeutic effect.

Is it safe to stop taking Alfuzosin HCl ER abruptly?
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While stopping Alfuzosin abruptly may not be dangerous, it can cause a return of BPH symptoms. Always consult with your healthcare provider before making any changes to your medication regimen.

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Comprehensive Drug Guide

How Does Alfuzosin HCl ER Work?

Alfuzosin HCl ER works by selectively blocking alpha-1 adrenergic receptors in the smooth muscle of the prostate and bladder neck. This relaxation of smooth muscle reduces resistance to urinary flow, thereby improving symptoms associated with benign prostatic hyperplasia such as difficulty urinating, weak stream, and frequent urination.

What is Alfuzosin HCl ER Used For?

Alfuzosin HCl ER is FDA-approved for the treatment of:

  • Benign prostatic hyperplasia (BPH) in adult men


Common Dosages

Alfuzosin HCl ER is commonly available in the following dosage:

  • 10 mg extended-release tablets


The typical dosing for Alfuzosin HCl ER is:


Adults: 10 mg once daily, typically taken after the same meal each day. It should be swallowed whole and not crushed or chewed.

Typical Dosing

FDA Approved Indications

  • For BPH: 10mg per day, taken after the same meal each day.

Off-Label Uses

There are no widely recognized off-label uses for Alfuzosin HCl ER.

Who Shouldn't Take Alfuzosin HCl ER?

Alfuzosin HCl ER should not be used in patients with:

  • Severe liver impairment
  • Known hypersensitivity to Alfuzosin or any of its components
  • Concurrent use with potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)


Advice From The Pharmacist

Patients taking Alfuzosin HCl ER should:

  • Take the medication as prescribed, ideally after the same meal each day to maintain consistent drug levels.
  • Avoid activities that require alertness, such as driving, until they know how the medication affects them, as dizziness or fainting may occur.
  • Inform their healthcare provider of all medications they are taking, as Alfuzosin may interact with other drugs.


Side Effects of Alfuzosin HCl ER

Common Side Effects

Common side effects of Alfuzosin HCl ER include:

  • Dizziness
  • Fatigue
  • Headache
  • Upper respiratory tract infection


Risks and Warnings of Alfuzosin HCl ER

Major risks and warnings associated with Alfuzosin HCl ER include:

  • Orthostatic Hypotension: Alfuzosin can cause a sudden drop in blood pressure when standing up, leading to dizziness or fainting.
  • QT Prolongation: Alfuzosin may affect heart rhythm, particularly in patients with a history of QT prolongation or those taking medications that affect the QT interval.
  • Hepatic Impairment: Use with caution in patients with mild to moderate liver impairment; Alfuzosin is contraindicated in severe hepatic impairment.

Interactions with Alfuzosin HCl ER

Common Drug Interactions

Alfuzosin HCl ER may interact with:

  • CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole): Increased risk of adverse effects due to higher Alfuzosin levels.
  • Antihypertensive Medications: Increased risk of hypotension.
  • PDE5 Inhibitors (e.g., sildenafil, tadalafil): May increase the risk of low blood pressure.

Patients should avoid excessive alcohol consumption, as it may exacerbate side effects like dizziness and low blood pressure.



Alternatives to Alfuzosin HCl ER

Alternative medications to Alfuzosin HCl ER include:

  • Tamsulosin (Flomax): Another alpha-blocker used for BPH.
  • Doxazosin: A non-selective alpha-blocker that also treats BPH and hypertension.
  • Finasteride: A 5-alpha-reductase inhibitor used for BPH, particularly in patients with larger prostates.