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AcipHex Sprinkle
AcipHex Sprinkle (rabeprazole sodium) is a proton pump inhibitor (PPI) prescribed primarily for the treatment of gastroesophageal reflux disease (GERD) and other conditions associated with excessive stomach acid. This medication works by decreasing the amount of acid produced in the stomach, which helps alleviate symptoms such as heartburn and acid reflux, and aids in the healing of erosive esophagitis caused by acid reflux.
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Frequently Asked Questions
How long does it take for AcipHex Sprinkle to work?
Most patients may experience relief from symptoms within 1 to 2 weeks, but full benefits may take up to 4 to 8 weeks.
Can I take AcipHex Sprinkle with food?
Yes, AcipHex Sprinkle can be taken with or without food. If you prefer, you can mix the contents of the capsule with applesauce or soft food.
Are there any long-term risks associated with AcipHex Sprinkle?
Yes, long-term use of PPIs like AcipHex may increase the risk of gastrointestinal infections, bone fractures, and kidney issues. Regular monitoring may be advised.
What should I do if I miss a dose of AcipHex Sprinkle?
If you miss a dose, take it as soon as you remember. If it's close to your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up.
Is AcipHex Sprinkle safe during pregnancy?
While studies have not shown significant risks, always consult your healthcare provider before taking any medication during pregnancy to weigh the benefits and risks.
Comprehensive Drug Guide
How Does AcipHex Sprinkle Work?
- Reduces gastric acid secretion: By blocking the proton pump, it decreases the production of stomach acid.
- Alleviates symptoms: This reduction in acid helps relieve symptoms of GERD and allows healing of esophageal lining.
Common Dosages
- Sprinkle capsules: Typically prescribed in a strength of 5 mg or 10 mg.
Typical Dosing
- The usual adult dose for GERD treatment is 20 mg once daily for up to 4 to 8 weeks.
- For children aged 1 to 11 years, the dosage may vary based on weight and is usually administered as 10 mg once daily.
Typical Dosing
FDA Approved Indications
- Treatment of gastroesophageal reflux disease (GERD)
- Erosive esophagitis due to acid reflux
- Helicobacter pylori eradication as part of a combination therapy
- Pathological hypersecretion conditions, such as Zollinger-Ellison syndrome
Pediatric Dosing
Who Shouldn't Take AcipHex Sprinkle?
- Hypersensitivity to rabeprazole or any components of the formulation
- Severe liver disease: Patients with severe hepatic impairment should use this medication with caution.
Advice From The Pharmacist
- AcipHex Sprinkle can be taken with or without food. If using the sprinkle form, it can be mixed with applesauce or soft foods, but should not be chewed or crushed.
- Stay consistent with your dosing schedule to maintain effective acid control.
- Inform your healthcare provider of any other medications you are taking, as AcipHex may interact with certain drugs.
Side Effects of AcipHex Sprinkle
Common Side Effects
- Headache
- Diarrhea
- Nausea
- Stomach pain
Uncommon/Severe Side Effects
- Clostridium difficile infection in the colon
- Bone fractures due to prolonged use
- Kidney issues, including acute interstitial nephritis
Risks and Warnings of AcipHex Sprinkle
- Long-term use of AcipHex Sprinkle may lead to an increased risk of gastrointestinal infections, such as C. difficile.
- Bone fractures: Patients, especially older adults, may be at higher risk of fractures with prolonged PPI use.
- Kidney problems: There have been reports of acute kidney injury; regular monitoring of kidney function may be necessary.
Interactions with AcipHex Sprinkle
Common Drug Interactions
- Clopidogrel: AcipHex may reduce the effectiveness of this medication, which is used to prevent blood clots.
- Methotrexate: Concomitant use may increase the risk of methotrexate toxicity.
- Other PPIs: Avoid combining with other proton pump inhibitors, as this can increase the risk of side effects.
Alternatives to AcipHex Sprinkle
- Omeprazole (Prilosec): Another widely used proton pump inhibitor for similar indications.
- Esomeprazole (Nexium): A PPI that is also effective in treating GERD and acid-related conditions.
- Lansoprazole (Prevacid): Another alternative in the PPI class.
- H2-receptor antagonists: Such as ranitidine or famotidine, which can also reduce stomach acid but work through a different mechanism.
