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Prevacid
Prevacid (generic name: lansoprazole) is a proton pump inhibitor (PPI) used to reduce the production of stomach acid. It is commonly prescribed for conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, and Zollinger-Ellison syndrome. By reducing the amount of acid in the stomach, Prevacid helps relieve symptoms such as heartburn, difficulty swallowing, and persistent cough, while promoting healing of the esophagus and stomach lining.
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Frequently Asked Questions
How long does it take for Prevacid to start working?
Prevacid typically starts reducing stomach acid within a few hours of taking the first dose, but it may take a few days to feel full relief from symptoms like heartburn.
Can I take Prevacid with other acid reducers like antacids?
Yes, you can take antacids (e.g., Tums) while on Prevacid for immediate relief of symptoms. However, they should not be used as a substitute for Prevacid.
What should I do if I miss a dose of Prevacid? If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses. What should I do if I miss a dose of Prevacid?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses.
Can I take Prevacid long-term?
Prevacid can be used long-term for certain conditions, but extended use should be closely monitored by your healthcare provider due to the risk of side effects like bone fractures and vitamin deficiencies.
Does Prevacid interact with other medications?
Yes, Prevacid can interact with medications such as clopidogrel, warfarin, and methotrexate. Always inform your healthcare provider of all the medications you are taking to avoid interactions.
Comprehensive Drug Guide
How Does Prevacid Work?
Prevacid works by inhibiting the H+/K+ ATPase enzyme in the stomach lining, which is responsible for secreting stomach acid. By blocking this enzyme, lansoprazole significantly reduces acid production, helping to alleviate acid-related conditions such as GERD and ulcers.
Common Dosages
- Delayed-release capsules: 15 mg, 30 mg
- Orally disintegrating tablets (Prevacid SoluTab): 15 mg, 30 mg
- Oral suspension: 15 mg, 30 mg per packet
Typical Dosing
- For GERD and erosive esophagitis, the typical dose is 15 mg to 30 mg once daily, depending on the severity and duration of the condition.
- For peptic ulcers, the usual dose is 30 mg once daily for 4 to 8 weeks.
- For Zollinger-Ellison syndrome, dosing varies and may be significantly higher, as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Gastroesophageal reflux disease (GERD)
- Erosive esophagitis
- Peptic ulcers (gastric and duodenal)
- Zollinger-Ellison syndrome (a condition causing excessive stomach acid production)
- Helicobacter pylori infection (as part of a combination therapy)
Who Shouldn't Take Prevacid?
- Known hypersensitivity to lansoprazole or other proton pump inhibitors.
- Severe liver disease or significant hepatic impairment, unless closely monitored by a healthcare provider.
Advice From The Pharmacist
- Take Prevacid 30 minutes before a meal, preferably in the morning, to maximize its effectiveness in reducing stomach acid.
- Do not crush or chew the delayed-release capsules. If swallowing is difficult, the capsules can be opened and the granules sprinkled on soft food (like applesauce).
- For the orally disintegrating tablets, allow them to dissolve on the tongue and do not swallow whole.
- Avoid alcohol, as it can exacerbate acid reflux and interfere with the medication's effectiveness.
Side Effects of Prevacid
Common Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Constipation
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Bone fractures (with long-term use)
- Vitamin B12 deficiency (with long-term use)
- Clostridium difficile infection (risk of severe diarrhea)
Risks and Warnings of Prevacid
- Long-Term Use Risks: Chronic use of Prevacid, especially over a period of more than a year, may increase the risk of bone fractures, low magnesium levels, and B12 deficiency. Regular monitoring is recommended for long-term users.
- Infection Risk: Proton pump inhibitors like Prevacid can increase the risk of Clostridium difficile-associated diarrhea and other gastrointestinal infections.
- Kidney Disease: There is an association between prolonged use of PPIs and chronic kidney disease. Patients on long-term therapy should have their kidney function monitored periodically.
Interactions with Prevacid
Common Drug Interactions
- Clopidogrel (Plavix): Prevacid may reduce the effectiveness of clopidogrel, increasing the risk of blood clots.
- Warfarin: PPIs can increase the effect of warfarin, leading to a higher risk of bleeding.
- Methotrexate: Lansoprazole may increase the levels of methotrexate in the blood, leading to toxicity.
Alternatives to Prevacid
- Omeprazole (Prilosec®): Another PPI used for similar conditions, often available over-the-counter.
- Esomeprazole (Nexium®): A PPI similar to Prevacid, often used for GERD and peptic ulcers.
- Ranitidine (Zantac®): A H2 receptor antagonist, previously used for heartburn and ulcers before its recall.
- Famotidine (Pepcid®): A H2 blocker, another alternative for reducing stomach acid.
