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Accolate
Accolate, also known as zafirlukast, is a leukotriene receptor antagonist. It's primarily used to manage and prevent chronic asthma in people over five years old. This medicine works by blocking certain enzymes in the body that trigger asthma symptoms. Remember, this medication won't help during an active asthma attack. Some common side effects include stomach pain, headache, or cold symptoms (such as sore throat and stuffy nose).
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Frequently Asked Questions
What happens if I miss a dosage?
If it's close to your next dosage, skip the missed one and continue the usual schedule. If it's still some time for the next dose, take the missed dose as soon as you remember.
Can Accolate be used for a sudden asthma attack?
No, Accolate is not designed for immediate relief. It's a preventative medication used in the long-term treatment of asthma.
Can I take Accolate during pregnancy?
The effects of Accolate during pregnancy are unknown. Consult your healthcare provider if you're planning a pregnancy or if you're already pregnant. Ensure to use an effective form of birth control while on this medication.
Is it safe for children to take Accolate?
Yes, children ages 5 and older can take Accolate. However, always refer to the doctor's instructions about dosage and use for your child.
Comprehensive Drug Guide
How Does Accolate Work?
Accolate is a leukotriene receptor antagonist that blocks the actions of leukotrienes, substances in the body that cause inflammation, edema, mucous secretion, and bronchoconstriction in asthmatic patients.
What is Accolate Used For?
FDA indications:
Accolate is used as a long-term treatment for preventing asthma attacks.
What is it used for off-label?
Allergic rhinitis: Some studies show Accolate may provide some relief from symptoms.
Aspirin-induced asthma: It is effective in the prevention of this variant of asthma.
Common Dosages
Tablets: 10mg, 20mg
Typical Dosing
Who Shouldn't Take Accolate?
- Patients with liver disease or abnormal liver function.
- Patients allergic to zafirlukast, which is the active ingredient in Accolate.
- If you are pregnant or breastfeeding, consult with your doctor before taking this medication, as it's unclear whether it could harm the baby.
Advice From The Pharmacist
- - Accolate should be taken on an empty stomach, at least 1 hour before or 2 hours after meals.
- - Don't suddenly quit using Accolate without talking to your doctor.
- - Be sure to notify your doctor if you miss a dose and do not double up on the next one.
- - Reach out to your healthcare specialist if you encounter recurrent symptoms or if symptoms worsen after initiating the medication.
- - Be on the lookout for lethargy, nausea, flu-like symptoms, severe abdominal pain, loss of appetite, darkened urine or jaundice. These may be symptoms of a serious liver condition known as Churg-Strauss syndrome.
- - If you're feeling excessively anxious, depressed, or have feelings of hurting yourself, let your doctor know. Consult immediately if you have numbness or tingling, muscle weakness, or a severe headache.
Side Effects of Accolate
Common Side Effects
- Common side effects:
- - You may experience headaches quite often.
- - Nausea can be a common occurrence and may sometimes lead to vomiting.
- - You may also find yourself prone to frequent infections, for instance, a common cold or flu.
Uncommon/Severe Side Effects
- Rare side effects:
- - There could be alterations in your liver function tests.
- - In very rare cases, you may experience an allergic reaction, hives, rash, or itching among the symptoms.
- Severe side effects:
- - If you experience any difficulty in breathing, this can be a serious side effect and you should seek medical help urgently.
- - Similarly, if you notice your face, lips, tongue, or throat swelling, this is likely a severe allergic reaction and requires immediate medical attention.
Risks and Warnings of Accolate
- Accolate can potentially cause liver damage. Frequent blood tests are required to keep track of liver function.
- This medication isn?t suggested if you've ever had cases of liver disease or liver function abnormalities.
- If you're pregnant, planning pregnancy, or breastfeeding, consult with your healthcare provider before starting this treatment regimen.
- Patients with a history of mood disorders or mental health issues should veer carefully as Accolate may potentially aggravate these symptoms.
Interactions with Accolate
Common Drug Interactions
- Warfarin
- Theophylline
- Tolbutamide
- Erythromycin
- Aspirin (in low doses)
- It's also crucial to tell your doctor if you're on any herbal or non-prescribed supplement since it may have an interaction with Accolate.
Alternatives to Accolate
- Singulair (Montelukast)
- Zyflo (Zileuton)
