NiHowdy > Drug Classes > Tumor Necrosis Factor Blockers

Browse Medications by Drug Class: Tumor Necrosis Factor Blockers

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are Tumor Necrosis Factor Blockers?

Tumor necrosis factor (TNF) blockers are a class of medications used to treat autoimmune and inflammatory conditions by targeting and neutralizing tumor necrosis factor-alpha (TNF-α), a protein involved in inflammation. By inhibiting TNF-α, these medications help reduce inflammation and prevent tissue damage associated with conditions like rheumatoid arthritis, Crohn's disease, and psoriasis. A unique feature of TNF blockers is their ability to provide targeted immunosuppression, improving quality of life for patients with chronic autoimmune disorders. NiHowdy ensures affordable access to these advanced therapies, empowering patients to manage their conditions effectively.

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List of drugs in Tumor Necrosis Factor Blockers

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Enbrel	Enbrel Information	Enbrel Pricing
Enbrel Mini	Enbrel Mini Information	Enbrel Mini Pricing
Enbrel SureClick	Enbrel SureClick Information	Enbrel SureClick Pricing
Simponi	Simponi Information	Simponi Pricing

Brief history about Tumor Necrosis Factor Blockers?

TNF blockers were first introduced in the late 1990s, starting with the approval of infliximab for rheumatoid arthritis and Crohn's disease. These drugs revolutionized the treatment of autoimmune disorders by providing an effective alternative to traditional immunosuppressive therapies. Over time, newer TNF blockers such as etanercept, adalimumab, and certolizumab pegol were developed, offering expanded treatment options and improved patient outcomes. These medications have since become a cornerstone in managing autoimmune diseases. NiHowdy simplifies access to these life-changing treatments, ensuring affordability for patients.

How do Tumor Necrosis Factor Blockers work?

TNF blockers work by binding to TNF-α, a pro-inflammatory cytokine that plays a key role in the immune response. By neutralizing TNF-α, these medications prevent it from interacting with its receptors on immune cells, thereby reducing inflammation and halting the progression of autoimmune diseases. For example, adalimumab binds to TNF-α with high specificity, reducing inflammation in joints and other tissues. NiHowdy ensures patients can access these targeted therapies affordably, improving their ability to manage chronic conditions.

What are Tumor Necrosis Factor Blockers used to treat?

Rheumatoid Arthritis (RA)

TNF blockers like etanercept and infliximab are widely used to manage rheumatoid arthritis by reducing joint inflammation, slowing disease progression, and preventing joint damage. These medications improve mobility and quality of life for patients with moderate to severe RA.

Crohn's Disease

For Crohn's disease, TNF blockers such as adalimumab and certolizumab pegol help control intestinal inflammation, reduce symptoms like abdominal pain and diarrhea, and promote intestinal healing. They are particularly effective in moderate to severe cases.

Psoriasis and Psoriatic Arthritis

TNF blockers like etanercept and infliximab are used to treat moderate to severe plaque psoriasis and psoriatic arthritis. These drugs reduce skin lesions, joint pain, and swelling, improving physical appearance and joint function.

Ankylosing Spondylitis

Patients with ankylosing spondylitis benefit from TNF blockers, which help reduce spinal inflammation, improve mobility, and alleviate back pain. These medications slow disease progression and enhance quality of life.

Ulcerative Colitis

TNF blockers such as infliximab are used to manage moderate to severe ulcerative colitis by reducing inflammation in the colon, relieving symptoms, and promoting mucosal healing.

Who should consider Tumor Necrosis Factor Blockers medications?

Adults

Adults with autoimmune diseases like rheumatoid arthritis, Crohn's disease, or psoriasis benefit significantly from TNF blockers. These medications provide targeted relief from inflammation, improve mobility, and reduce symptoms, enhancing overall quality of life.

Children

TNF blockers are used in pediatric populations for conditions like juvenile idiopathic arthritis and pediatric Crohn's disease. Doses are carefully adjusted to ensure safety and effectiveness, with regular monitoring to minimize side effects.

Seniors

Seniors with autoimmune diseases benefit from TNF blockers but require careful assessment due to age-related changes in immune function and potential risks of infections. Healthcare providers closely monitor older patients to ensure safe and effective treatment.

Are Tumor Necrosis Factor Blockers safe?

TNF blockers are generally safe when used as prescribed but can increase the risk of infections due to their immunosuppressive effects. Common side effects include injection site reactions, mild upper respiratory infections, and headaches. Rare but serious risks include reactivation of latent infections (e.g., tuberculosis), malignancies, and autoimmune reactions. Regular monitoring and adherence to prescribed regimens ensure safe use of these medications.

Can I take Tumor Necrosis Factor Blockers during pregnancy?

Some TNF blockers, like certolizumab pegol, are considered safe during pregnancy, particularly in the second and third trimesters. Pregnant individuals should consult their healthcare provider to weigh the risks and benefits and determine the best course of treatment.

Are Tumor Necrosis Factor Blockers safe to take while lactating?

Certain TNF blockers, such as adalimumab and etanercept, are considered safe for use during breastfeeding due to minimal transfer into breast milk. Patients should consult their healthcare provider to ensure the safety of their chosen treatment.

Are Tumor Necrosis Factor Blockers controlled substances?

TNF blockers are not classified as controlled substances. They are available by prescription for managing autoimmune and inflammatory conditions. Regular follow-ups with healthcare providers ensure proper use and monitoring.

Side effects of Tumor Necrosis Factor Blockers?

TNF blockers are effective but may cause side effects. Common side effects include injection site reactions (e.g., redness, swelling, or pain), mild upper respiratory infections, and headaches. These effects are typically mild and resolve on their own. Less common side effects include nausea, fatigue, or dizziness. Adjustments to dosing schedules or supportive care can alleviate these symptoms. Rare but serious side effects include increased susceptibility to infections, such as tuberculosis or fungal infections, and the potential for malignancies like lymphoma. Patients should undergo regular screenings and inform their healthcare provider of any unusual symptoms, such as persistent fever or unexplained weight loss. Healthcare providers recommend regular monitoring and communication to minimize risks and optimize the benefits of TNF blockers. Adherence to prescribed regimens and prompt reporting of side effects ensure effective and safe treatment.

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Cost considerations and insurance coverage for Tumor Necrosis Factor Blockers

TNF blockers are often expensive due to their advanced manufacturing processes. However, most insurance plans cover these medications for approved conditions, such as rheumatoid arthritis or Crohn's disease. Patient assistance programs and NiHowdy's discounts, rebates, and Bitcoin rewards make these therapies more accessible and affordable.

How do I get rebates on Tumor Necrosis Factor Blockers?

NiHowdy's Bitcoin rebate program for TNF blockers offers patients a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing autoimmune conditions both affordable and rewarding, ensuring access to effective treatments while building long-term value.