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Enbrel Mini

Enbrel Mini is a brand name for etanercept, a biologic medication used to treat autoimmune conditions like rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis, plaque psoriasis, and juvenile idiopathic arthritis (JIA). Enbrel Mini is a tumor necrosis factor (TNF) inhibitor, which works by blocking the activity of TNF, a protein that causes inflammation in the body. By reducing inflammation, Enbrel Mini helps control the symptoms of these autoimmune diseases, improving joint function and reducing pain and swelling.


Drug Availability and Controlled Substance Status

Enbrel Mini is available by prescription only and is not classified as a controlled substance. It is available in a pre-filled, single-use autoinjector (Enbrel Mini with AutoTouch) designed for easier self-administration. The standard dose is 50 mg.

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Frequently Asked Questions

How long does it take for Enbrel Mini to work?
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Many patients begin to see improvements in their symptoms within 2 to 4 weeks, though it may take up to 3 months to experience the full benefits of the medication.

How long does it take for Enbrel Mini to work?
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Many patients begin to see improvements in their symptoms within 2 to 4 weeks, though it may take up to 3 months to experience the full benefits of the medication.

Can I take Enbrel Mini if I have a cold?
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If you have a mild cold, it is generally safe to continue using Enbrel Mini. However, if you develop a more serious infection or fever, contact your healthcare provider, as you may need to pause the medication.

Can I travel with Enbrel Mini?
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Yes, you can travel with Enbrel Mini, but it must be kept refrigerated. Use an insulated travel cooler to keep the medication cold, and avoid freezing it. If refrigeration is not possible for a short period, Enbrel can be kept at room temperature for up to 14 days.

Can Enbrel Mini be used in children?
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Yes, Enbrel Mini is approved for use in children aged 2 years and older with juvenile idiopathic arthritis (JIA) and children aged 4 years and older with plaque psoriasis.

Will I need regular blood tests while taking Enbrel Mini?
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Yes, regular blood tests are typically required to monitor for infections, liver function, and blood cell counts. This helps ensure the medication is working safely and effectively.

Comprehensive Drug Guide

How Does Enbrel Mini Work?

Etanercept, the active ingredient in Enbrel Mini, works by binding to tumor necrosis factor (TNF), a protein that plays a key role in the inflammation process. TNF promotes inflammation, which contributes to the symptoms of autoimmune diseases such as pain, swelling, and joint damage. By inhibiting TNF, Enbrel Mini reduces these inflammatory responses, helping to alleviate symptoms and prevent disease progression.



What is Enbrel Mini Used For?


Common Dosages

Enbrel Mini is available as a 50 mg autoinjector for subcutaneous injection. The typical dosing is:

  • 50 mg once weekly for most adult conditions (RA, PsA, ankylosing spondylitis).
  • 25 mg twice weekly may be used in some patients for RA, based on their physician's recommendations.

Typical Dosing

  • For rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The usual dose is 50 mg once weekly via subcutaneous injection.
  • For plaque psoriasis: The typical dose is 50 mg twice weekly for the first 3 months, followed by 50 mg once weekly as a maintenance dose.
  • For juvenile idiopathic arthritis: The dose is based on weight, with typical dosing of 0.8 mg/kg once weekly.

Typical Dosing

FDA Approved Indications

  • Rheumatoid arthritis (RA) in adults
  • Psoriatic arthritis (PsA)
  • Ankylosing spondylitis
  • Plaque psoriasis in adults and children (4 years and older)
  • Juvenile idiopathic arthritis (JIA) in children aged 2 and older

Who Shouldn't Take Enbrel Mini?

  • Sepsis or risk of serious infection
  • Known hypersensitivity to etanercept or any component of the formulation
  • Active tuberculosis or untreated latent tuberculosis (TB)


Advice From The Pharmacist

  • Enbrel Mini is administered as a subcutaneous injection. Your healthcare provider will show you how to use the autoinjector if you are self-administering the medication at home.
  • Rotate injection sites between the thighs, abdomen, or upper arms to reduce irritation. Avoid injecting into areas that are red, swollen, or bruised.
  • Store Enbrel Mini in the refrigerator and allow it to reach room temperature for about 15-30 minutes before injection. Do not shake the autoinjector.
  • Keep up with regular monitoring and tests for infections, including tuberculosis (TB), as TNF inhibitors like Enbrel Mini can increase the risk of serious infections.


Side Effects of Enbrel Mini

Common Side Effects

  • Injection site reactions (pain, redness, swelling)
  • Upper respiratory infections (common cold, sinus infections)
  • Headache
  • Nausea
  • Fatigue


Uncommon/Severe Side Effects

  • Serious infections (bacterial, fungal, viral) such as tuberculosis, pneumonia, or sepsis
  • Reactivation of hepatitis B
  • New or worsening heart failure
  • Blood disorders (low white blood cell count)
  • Lymphoma or other cancers


Risks and Warnings of Enbrel Mini

  • Infection Risk: TNF inhibitors, including Enbrel Mini, increase the risk of serious infections. Patients should be screened for latent tuberculosis before starting treatment and monitored regularly for signs of infection.
  • Cancer Risk: Some studies suggest an increased risk of certain cancers, including lymphoma, in patients taking TNF inhibitors, especially in children and adolescents.
  • Heart Failure: Enbrel Mini may worsen heart failure in patients with pre-existing heart conditions. Patients should be monitored closely for new or worsening heart failure symptoms.
  • Neurological Problems: Rare cases of demyelinating diseases like multiple sclerosis have been reported in patients taking TNF inhibitors.

Interactions with Enbrel Mini

Common Drug Interactions

  • Live vaccines: Avoid receiving live vaccines while taking Enbrel Mini, as TNF inhibitors suppress the immune system and can increase the risk of infection from live vaccines.
  • Immunosuppressive drugs: Combining Enbrel Mini with other immunosuppressive medications may increase the risk of infections.
  • Anakinra and Abatacept: These medications should not be used in combination with Enbrel Mini due to an increased risk of serious infections.

Alternatives to Enbrel Mini

  • Humira (adalimumab): Another TNF inhibitor used to treat autoimmune conditions such as RA, PsA, and Crohn’s disease.
  • Remicade (infliximab): A biologic drug used to treat rheumatoid arthritis and other inflammatory conditions, typically administered by infusion.
  • Cimzia (certolizumab pegol): A TNF inhibitor used to treat RA, PsA, and ankylosing spondylitis.
  • Methotrexate: An oral or injectable medication often used in combination with biologics for the treatment of rheumatoid arthritis.