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Enbrel SureClick
Enbrel SureClick is a pre-filled auto-injector containing etanercept, a biologic medication used to treat autoimmune conditions such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis, plaque psoriasis, and juvenile idiopathic arthritis (JIA). Enbrel works by targeting and inhibiting tumor necrosis factor (TNF), a protein that causes inflammation in autoimmune diseases. By reducing TNF activity, Enbrel helps reduce inflammation, pain, and joint damage. The SureClick auto-injector is designed for easy and quick self-administration.
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Frequently Asked Questions
How long does it take for Enbrel SureClick to work?
Many patients begin to experience symptom relief within 2 to 4 weeks, though it may take up to 3 months to experience the full benefits of Enbrel SureClick.
Can I inject Enbrel SureClick at home?
Yes, after receiving instructions from your healthcare provider, you can self-administer Enbrel SureClick at home. It is designed for easy use with a pre-filled auto-injector.
What should I do if I miss a dose of Enbrel SureClick?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Can I take Enbrel SureClick if I’m pregnant?
There is limited information about the safety of Enbrel during pregnancy. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your healthcare provider.
How should I store Enbrel SureClick?
Store Enbrel SureClick in the refrigerator and allow it to reach room temperature before use. Avoid freezing it or exposing it to direct sunlight or heat.
Comprehensive Drug Guide
How Does Enbrel SureClick Work?
Etanercept, the active ingredient in Enbrel SureClick, works by inhibiting tumor necrosis factor (TNF), a key protein involved in the inflammatory response in autoimmune diseases. By blocking TNF, Enbrel reduces the inflammatory process, preventing damage to the joints and other tissues, and helps improve symptoms such as pain and swelling.
Common Dosages
- 50 mg once weekly for adults with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.
- For children with juvenile idiopathic arthritis, the dose is based on weight, with the typical dose being 0.8 mg/kg once weekly, up to a maximum of 50 mg.
Typical Dosing
- For rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: 50 mg administered once weekly via subcutaneous injection.
- For plaque psoriasis: An initial dose of 50 mg twice weekly for the first 3 months, followed by 50 mg once weekly as a maintenance dose.
- For juvenile idiopathic arthritis: Dosing is based on the child's weight, typically 0.8 mg/kg once weekly.
Typical Dosing
FDA Approved Indications
- Rheumatoid arthritis (RA) in adults
- Psoriatic arthritis (PsA)
- Ankylosing spondylitis
- Plaque psoriasis in adults and children aged 4 years and older
- Juvenile idiopathic arthritis (JIA) in children aged 2 years and older
Who Shouldn't Take Enbrel SureClick?
- Sepsis or active infection
- Known hypersensitivity to etanercept or any component of the formulation
- Active tuberculosis or untreated latent tuberculosis without appropriate treatment
Advice From The Pharmacist
- The SureClick auto-injector is designed for self-injection. Follow the instructions provided by your healthcare provider to ensure proper use. Inject the medication into the thigh, abdomen, or upper arm.
- Rotate injection sites with each dose to reduce the risk of skin irritation or injection site reactions.
- Store Enbrel SureClick in the refrigerator and allow it to come to room temperature for about 15-30 minutes before injecting. Do not shake the injector.
- Dispose of used auto-injectors in a sharps disposal container.
Side Effects of Enbrel SureClick
Common Side Effects
- Injection site reactions (redness, pain, swelling)
- Upper respiratory infections (e.g., colds, sinus infections)
- Headache
- Nausea
- Dizziness
Uncommon/Severe Side Effects
- Serious infections (e.g., tuberculosis, fungal, or bacterial infections)
- New or worsening heart failure
- Lymphoma or other cancers
- Demyelinating disorders (e.g., multiple sclerosis)
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Enbrel SureClick
- Serious Infections: Enbrel SureClick can increase the risk of serious infections, including tuberculosis and bacterial or fungal infections. Patients should be tested for tuberculosis before starting treatment and monitored for signs of infection during therapy.
- Cancer Risk: Some studies have shown an increased risk of lymphoma and other cancers, especially in children and adolescents using TNF inhibitors.
- Heart Failure: Enbrel may worsen or trigger new-onset heart failure. Patients with a history of heart failure should be monitored closely.
- Neurological Problems: TNF inhibitors like Enbrel have been associated with rare cases of demyelinating diseases, such as multiple sclerosis.
Interactions with Enbrel SureClick
Common Drug Interactions
- Live vaccines: Live vaccines should be avoided while taking Enbrel SureClick, as the medication suppresses the immune system and may increase the risk of infection from live vaccines.
- Immunosuppressive drugs: Combining Enbrel with other immunosuppressive medications may increase the risk of infection.
- Anakinra or Abatacept: These medications should not be used in combination with Enbrel due to an increased risk of serious infections.
Alternatives to Enbrel SureClick
- Humira (adalimumab): Another TNF inhibitor used to treat autoimmune conditions such as RA, PsA, and Crohn’s disease.
- Cimzia (certolizumab pegol): A biologic therapy used to treat RA, PsA, and ankylosing spondylitis.
- Remicade (infliximab): An intravenous TNF inhibitor used for RA, Crohn’s disease, and other inflammatory conditions.
- Methotrexate: A disease-modifying antirheumatic drug (DMARD) often used in combination with biologics for treating RA.
