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Zolpidem Tartrate ER
Zolpidem Tartrate ER (extended-release) is a sedative-hypnotic medication used to treat insomnia in adults, specifically for those who have difficulty falling asleep or staying asleep throughout the night. It is an extended-release formulation of zolpidem that helps you fall asleep quickly and stay asleep by slowly releasing the drug over time. Zolpidem belongs to a class of drugs known as GABA receptor agonists, which promote sleep by calming brain activity.
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Frequently Asked Questions
How quickly does Zolpidem Tartrate ER work?
Zolpidem Tartrate ER typically begins to work within 30 minutes, helping patients fall asleep quickly and stay asleep throughout the night.
Can I take Zolpidem Tartrate ER every night?
Zolpidem Tartrate ER is intended for short-term use, generally for 1-2 weeks. Long-term use may lead to dependence, so it is important to follow your healthcare provider’s recommendations and use it only as prescribed.
What should I do if I miss a dose of Zolpidem Tartrate ER?
If you miss a dose and do not have enough time for a full night's sleep (7-8 hours), skip the missed dose. Do not take Zolpidem Tartrate ER if you cannot get a full night of sleep after taking it.
Can I drive the next day after taking Zolpidem Tartrate ER?
Zolpidem Tartrate ER may cause next-day drowsiness or impair your ability to perform tasks that require alertness, such as driving. Avoid driving or operating heavy machinery the morning after taking the medication, especially if you did not get a full 7-8 hours of sleep.
Is Zolpidem Tartrate ER safe for long-term use?
Zolpidem Tartrate ER is generally not recommended for long-term use due to the risk of dependence and tolerance. If you find that you need ongoing sleep medication, consult your healthcare provider for alternative treatments or adjustments to your therapy.
Comprehensive Drug Guide
How Does Zolpidem Tartrate ER Work?
Zolpidem Tartrate ER works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that inhibits activity and promotes calmness. By binding to GABA receptors, Zolpidem helps slow down brain activity, making it easier to fall asleep and stay asleep throughout the night. The extended-release formulation allows for an initial quick onset of sleep, followed by a prolonged effect to maintain sleep.
Common Dosages
- 6.25 mg extended-release tablets
- 12.5 mg extended-release tablets
Typical Dosing
- For insomnia: The recommended starting dose is 6.25 mg once daily, taken immediately before bedtime. For patients who require a higher dose, 12.5 mg may be prescribed. The tablet should be taken on an empty stomach to ensure faster absorption. The maximum dose is 12.5 mg per night.
Typical Dosing
FDA Approved Indications
- Insomnia, particularly in patients who have trouble staying asleep during the night
Who Shouldn't Take Zolpidem Tartrate ER?
- Known hypersensitivity to zolpidem or any components of the formulation
- History of complex sleep behaviors (e.g., sleepwalking, sleep-driving)
- Severe liver impairment
Advice From The Pharmacist
- Take Zolpidem Tartrate ER immediately before bedtime when you can devote at least 7-8 hours to sleep. Taking it without enough time for sleep may lead to next-day drowsiness.
- Avoid alcohol and other central nervous system depressants while taking Zolpidem, as they can increase the sedative effects and lead to dangerous side effects like impaired breathing or coordination.
- Do not crush, chew, or break the extended-release tablet. Swallow it whole to ensure proper drug release throughout the night.
- Zolpidem can be habit-forming, so use it only as prescribed. Do not increase your dose without consulting your healthcare provider.
Side Effects of Zolpidem Tartrate ER
Common Side Effects
- Drowsiness or daytime drowsiness
- Dizziness
- Headache
- Nausea
- Dry mouth
Uncommon/Severe Side Effects
- Complex sleep behaviors (e.g., sleepwalking, sleep-driving)
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Depression or suicidal thoughts
- Next-day impaired alertness (especially if taken without enough time for sleep)
Risks and Warnings of Zolpidem Tartrate ER
- Complex Sleep Behaviors: Zolpidem Tartrate ER has been associated with activities such as sleepwalking, sleep-driving, and performing tasks while not fully awake, often without recollection. Discontinue use and contact your healthcare provider if these behaviors occur.
- Dependence and Withdrawal: Long-term use of Zolpidem can lead to dependence. Abruptly stopping the medication may result in withdrawal symptoms such as anxiety, agitation, and rebound insomnia.
- Next-Day Impairment: Zolpidem Tartrate ER can cause next-day drowsiness and impair your ability to drive or perform tasks requiring alertness, especially if taken without a full night’s sleep (7-8 hours).
Interactions with Zolpidem Tartrate ER
Common Drug Interactions
- CNS depressants (e.g., alcohol, benzodiazepines, opioids): Combining Zolpidem with other CNS depressants increases the risk of sedation, respiratory depression, and other serious side effects.
- Antidepressants: Some antidepressants, such as SSRIs, may interact with Zolpidem and increase the risk of side effects like dizziness or confusion.
- Ketoconazole: This antifungal medication may increase the blood levels of Zolpidem, leading to a higher risk of side effects.
Alternatives to Zolpidem Tartrate ER
- Lunesta (eszopiclone): Another sedative-hypnotic used for insomnia that may be better for patients who need help both falling and staying asleep.
- Ambien (zolpidem): The immediate-release form of zolpidem, which is better for patients who have difficulty falling asleep but do not need extended action throughout the night.
- Melatonin supplements: A natural sleep aid used for mild insomnia or circadian rhythm disorders.
