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Zolpidem Tartrate
Zolpidem Tartrate is a sedative-hypnotic medication used to treat insomnia, particularly for individuals who have difficulty falling asleep. It is available in an immediate-release form that helps you fall asleep quickly by calming brain activity. Zolpidem works by targeting GABA receptors, promoting sleep by slowing down the brain’s activity. It is intended for short-term use and helps manage acute sleep disturbances.
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Frequently Asked Questions
How fast does Zolpidem Tartrate work?
Zolpidem typically starts working within 15-30 minutes, so it’s best to take it immediately before going to bed.
Can I take Zolpidem Tartrate every night?
Zolpidem Tartrate is intended for short-term use. Long-term use may lead to dependence, so it is important to follow your healthcare provider’s instructions and use it only as needed.
What should I do if I miss a dose of Zolpidem?
If you miss a dose but do not have enough time for a full night’s sleep (7-8 hours), skip the missed dose. Do not take Zolpidem if you cannot devote the necessary time to sleep.
Can I drive the next day after taking Zolpidem?
Zolpidem may cause next-day drowsiness and impair your ability to drive or perform tasks requiring alertness. Avoid driving or operating heavy machinery the morning after taking the medication, especially if you didn’t get enough sleep.
Is Zolpidem safe for long-term use?
Zolpidem is generally prescribed for short-term use to manage acute insomnia. Long-term use may lead to tolerance, dependence, or other side effects, so consult your healthcare provider if you require ongoing sleep aid.
Comprehensive Drug Guide
How Does Zolpidem Tartrate Work?
Zolpidem works by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits activity in the brain. This calming effect helps people fall asleep faster by reducing brain activity. Unlike the extended-release form, Zolpidem Tartrate’s immediate release makes it ideal for treating difficulties with falling asleep rather than staying asleep.
What is Zolpidem Tartrate Used For?
Common Dosages
- 5 mg tablets
- 10 mg tablets
Typical Dosing
- For insomnia: The recommended dose for adults is 5 mg to 10 mg once daily, taken immediately before bedtime. The dose should be adjusted based on individual response, but the maximum dose is 10 mg per night. For elderly or debilitated patients, a lower starting dose of 5 mg is recommended.
Typical Dosing
FDA Approved Indications
- Short-term insomnia, particularly for individuals who have trouble falling asleep
Off-Label Uses
Pediatric Dosing
Who Shouldn't Take Zolpidem Tartrate?
- Known hypersensitivity to zolpidem or any components of the formulation
- History of complex sleep behaviors (e.g., sleepwalking, sleep-driving)
- Severe liver impairment
Advice From The Pharmacist
- Zolpidem should be taken immediately before going to bed when you can devote at least 7-8 hours to sleep. Taking it without enough time for sleep can lead to next-day drowsiness.
- Avoid alcohol and other central nervous system depressants while taking Zolpidem, as these can increase sedation and the risk of dangerous side effects like impaired breathing.
- Zolpidem is intended for short-term use (usually 1-2 weeks). Prolonged use can lead to dependence, so follow your doctor’s instructions and avoid increasing the dose on your own.
- If you experience unusual behaviors, such as sleepwalking, sleep-driving, or performing tasks while not fully awake, discontinue Zolpidem and contact your healthcare provider.
Side Effects of Zolpidem Tartrate
Common Side Effects
- Drowsiness or daytime drowsiness
- Dizziness
- Headache
- Nausea
- Dry mouth
Uncommon/Severe Side Effects
- Complex sleep behaviors (e.g., sleepwalking, sleep-driving)
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Next-day impairment (reduced alertness or impaired coordination)
Risks and Warnings of Zolpidem Tartrate
- Complex Sleep Behaviors: Zolpidem has been associated with activities such as sleepwalking, sleep-driving, and performing tasks while not fully awake, often without memory of the event. Discontinue the medication if these behaviors occur.
- Dependence and Withdrawal: Long-term use of Zolpidem may lead to physical dependence, and abrupt discontinuation can result in withdrawal symptoms, such as anxiety, agitation, or rebound insomnia.
- Next-Day Impairment: Zolpidem can cause next-day drowsiness and impair your ability to perform tasks requiring full alertness, especially if taken without enough time for sleep.
Interactions with Zolpidem Tartrate
Common Drug Interactions
- CNS depressants (e.g., alcohol, benzodiazepines, opioids): Combining Zolpidem with other CNS depressants increases the risk of sedation, respiratory depression, and other serious side effects.
- Antidepressants: Some antidepressants, such as SSRIs, may interact with Zolpidem and increase the risk of side effects like dizziness or confusion.
- Ketoconazole: This antifungal medication may increase the levels of Zolpidem in the bloodstream, leading to a higher risk of side effects.
Common Food Interactions
Alternatives to Zolpidem Tartrate
- Lunesta (eszopiclone): A sedative-hypnotic used for treating insomnia, effective for helping both with falling and staying asleep.
- Ambien CR (zolpidem extended-release): The extended-release form of zolpidem, used for those who have difficulty staying asleep throughout the night.
- Melatonin supplements: A natural sleep aid used for mild sleep disturbances and circadian rhythm disorders.
