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Zohydro ER
Zohydro ER (hydrocodone bitartrate) is an extended-release opioid analgesic used to manage severe pain that requires around-the-clock treatment and cannot be controlled with other pain medications. It is a powerful pain reliever designed for long-term use and should only be used when other treatment options are inadequate. Zohydro ER works by altering the brain's perception of pain and is intended for individuals who need continuous pain relief.
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Frequently Asked Questions
How long does Zohydro ER take to start working?
Zohydro ER typically begins to relieve pain within 1-2 hours after taking a dose, and the extended-release formulation provides pain relief for up to 12 hours.
Can I stop taking Zohydro ER suddenly?
No, do not stop taking Zohydro ER suddenly without consulting your healthcare provider. Abrupt discontinuation can lead to withdrawal symptoms, including anxiety, sweating, and nausea. Your doctor will provide a tapering schedule to help reduce dependence safely.
Is Zohydro ER safe for long-term use?
Zohydro ER can be used for long-term pain management in patients who need continuous opioid therapy. However, it carries a risk of addiction, abuse, and dependence, so it should be used with caution and under strict medical supervision.
Can I drink alcohol while taking Zohydro ER?
No, you should avoid alcohol while taking Zohydro ER. Combining alcohol with this medication can increase the risk of severe sedation, respiratory depression, or overdose, which can be fatal.
What should I do if I miss a dose of Zohydro ER?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take an extra dose to make up for the missed one.
Comprehensive Drug Guide
How Does Zohydro ER Work?
Zohydro ER works by binding to mu-opioid receptors in the brain and spinal cord, altering the perception of pain. It also affects other systems in the body, leading to a sense of euphoria and relaxation, which can contribute to its potential for abuse. The extended-release formulation slowly releases hydrocodone over a 12-hour period, providing long-lasting pain relief.
Common Dosages
- 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg extended-release capsules
Typical Dosing
- For chronic pain: The initial dose is typically 10 mg every 12 hours, with adjustments made based on individual response and tolerance. The dosage may be increased gradually, but the lowest effective dose should be used to minimize the risk of side effects and dependence.
Typical Dosing
FDA Approved Indications
- Severe pain requiring long-term, around-the-clock opioid treatment when other pain relief options are insufficient
Who Shouldn't Take Zohydro ER?
- Severe respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting
- Known hypersensitivity to hydrocodone or any components of the formulation
- Gastrointestinal obstruction (e.g., paralytic ileus)
Advice From The Pharmacist
- Take Zohydro ER exactly as prescribed, and do not crush, chew, or dissolve the capsules, as doing so can lead to rapid release and absorption of a potentially fatal dose of hydrocodone.
- Swallow the capsules whole with a full glass of water, and take them at the same time each day to maintain consistent pain control.
- Zohydro ER may cause drowsiness, so avoid driving or operating heavy machinery until you know how the medication affects you.
- Do not abruptly stop taking Zohydro ER without consulting your healthcare provider, as doing so may lead to withdrawal symptoms.
- Avoid alcohol and other central nervous system depressants while taking Zohydro ER, as this can increase the risk of dangerous side effects like severe drowsiness, respiratory depression, or death.
Side Effects of Zohydro ER
Common Side Effects
- Drowsiness
- Constipation
- Nausea
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Respiratory depression (slow or shallow breathing)
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Hypotension (low blood pressure)
- Addiction, abuse, and misuse (leading to overdose or death)
Risks and Warnings of Zohydro ER
- Respiratory Depression: Zohydro ER can cause life-threatening respiratory depression, particularly when starting treatment or after a dose increase. Patients should be closely monitored for signs of shallow breathing.
- Abuse and Dependence: Zohydro ER has a high potential for abuse, and prolonged use can lead to physical and psychological dependence. The medication should only be prescribed to patients who require long-term opioid therapy.
- Accidental Overdose: Taking higher doses than prescribed or combining Zohydro ER with other depressants such as alcohol, benzodiazepines, or other opioids can result in fatal overdose.
- Withdrawal Symptoms: Abrupt discontinuation of Zohydro ER can lead to withdrawal symptoms, including agitation, sweating, anxiety, and muscle aches. The medication should be tapered off under medical supervision.
Interactions with Zohydro ER
Common Drug Interactions
- CNS depressants (e.g., alcohol, benzodiazepines, sedatives): Combining Zohydro ER with other CNS depressants increases the risk of severe sedation, respiratory depression, coma, or death.
- MAO inhibitors: Taking Zohydro ER with monoamine oxidase inhibitors (MAOIs) may result in severe, life-threatening reactions. Zohydro ER should not be used within 14 days of taking an MAOI.
- CYP3A4 inhibitors: Drugs that inhibit CYP3A4 (e.g., ketoconazole, erythromycin) can increase the levels of hydrocodone in the body, raising the risk of side effects and overdose.
Alternatives to Zohydro ER
- OxyContin (oxycodone extended-release): Another opioid analgesic used for long-term, around-the-clock pain management.
- Morphine ER: A long-acting opioid used for managing severe chronic pain.
- Fentanyl patches: A transdermal system used for continuous, long-term pain relief in patients who are opioid-tolerant.
- Non-opioid pain relievers (e.g., acetaminophen, NSAIDs): May be suitable for patients with milder pain or those who wish to avoid opioids.
