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Zilretta
Zilretta (triamcinolone acetonide extended-release injectable suspension) is a corticosteroid used for the treatment of osteoarthritis (OA) pain in the knee. Zilretta is specifically designed as an extended-release formulation to provide long-lasting relief by slowly releasing the medication into the knee joint over time. It helps reduce inflammation, swelling, and pain, allowing for improved mobility and function in patients with knee osteoarthritis. Unlike immediate-release corticosteroids, Zilretta offers prolonged relief, typically lasting for several months after a single injection.
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Frequently Asked Questions
How long does it take for Zilretta to start working?
Many patients begin to feel relief within 1-2 weeks after receiving the injection, with pain relief lasting for up to 3-6 months depending on the individual.
Can Zilretta be used for other joints besides the knee?
No, Zilretta is specifically approved for knee osteoarthritis and is not intended for use in other joints. Consult your healthcare provider for other treatment options if you have osteoarthritis in other joints.
How often can I receive Zilretta injections?
Zilretta injections can typically be administered every 3-6 months depending on the severity of symptoms. However, the number of injections should be limited to avoid joint damage from repeated corticosteroid use.
What should I do if I experience pain after the injection?
Mild pain or discomfort at the injection site is common after receiving Zilretta. You can apply ice to the area to reduce swelling and discomfort. If the pain persists or worsens, contact your healthcare provider.
Can Zilretta cure osteoarthritis?
No, Zilretta does not cure osteoarthritis. It helps manage the symptoms, such as pain and inflammation, but the underlying condition remains. Long-term management strategies, including physical therapy and lifestyle changes, may be recommended alongside Zilretta.
Comprehensive Drug Guide
How Does Zilretta Work?
Zilretta contains triamcinolone acetonide, a corticosteroid that works by reducing inflammation in the joint. It inhibits the release of substances in the body that cause inflammation, such as prostaglandins and cytokines. The extended-release formulation allows for a slow and steady release of the medication into the knee joint, providing long-term pain relief and reducing inflammation over several months.
Common Dosages
- Zilretta is supplied as a 32 mg single-dose, extended-release suspension for intra-articular injection into the knee. The injection is typically administered once every 3-6 months depending on the patient's response and symptom relief.
Typical Dosing
- For osteoarthritis of the knee, the recommended dose is one intra-articular injection of Zilretta (32 mg) directly into the affected knee. The injection can be repeated as necessary, usually every 3-6 months based on the patient’s symptoms and physician recommendations.
- It is important to note that Zilretta is not intended for systemic use or injection into other joints besides the knee.
Typical Dosing
FDA Approved Indications
- Osteoarthritis pain of the knee in adults.
Who Shouldn't Take Zilretta?
- Hypersensitivity to triamcinolone acetonide or any other components of the formulation.
- Active infections in or around the injection site.
- Systemic fungal infections, as corticosteroids can worsen these infections.
Advice From The Pharmacist
- Zilretta is injected into the knee by a healthcare professional and is not self-administered. Follow your doctor’s instructions for post-injection care.
- After receiving the injection, avoid excessive weight-bearing activities or strenuous exercise involving the treated knee for at least 48 hours to allow the medication to settle and reduce the risk of joint irritation.
- Monitor for signs of infection around the injection site, such as redness, swelling, or increased pain. If you experience these symptoms, contact your healthcare provider immediately.
- If you have diabetes, be aware that corticosteroids like Zilretta can cause temporary increases in blood sugar levels.
Side Effects of Zilretta
Common Side Effects
- Joint pain or discomfort at the injection site
- Swelling or bruising at the injection site
- Headache
- Cough or respiratory symptoms
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Joint infection or septic arthritis
- Thinning or weakening of the joint tissue with repeated injections
Risks and Warnings of Zilretta
- Infection Risk: Although rare, there is a risk of joint infection (septic arthritis) following an intra-articular injection. Patients should monitor for symptoms such as increased pain, swelling, warmth, or redness around the knee and report these to their healthcare provider immediately.
- Joint Deterioration: Repeated corticosteroid injections can weaken joint tissues over time. While Zilretta is designed for extended-release and long-term relief, patients should not exceed the recommended frequency of injections.
- Blood Sugar Changes: Corticosteroids can cause temporary increases in blood sugar levels, especially in diabetic patients. Blood sugar should be monitored closely following the injection.
Interactions with Zilretta
Common Drug Interactions
- There are no significant drug interactions associated with Zilretta due to its local administration. However, patients should inform their healthcare provider of any medications they are taking, particularly if they are on systemic corticosteroids or immunosuppressive therapies.
Alternatives to Zilretta
- Corticosteroid injections (immediate-release): Such as triamcinolone acetonide or methylprednisolone injections, which provide more immediate, but shorter-term relief.
- Hyaluronic acid injections: A gel-like substance that acts as a lubricant and shock absorber in the knee, used for osteoarthritis pain.
- NSAIDs (Nonsteroidal anti-inflammatory drugs): Such as ibuprofen or naproxen, which can provide temporary relief for osteoarthritis pain.
- Physical therapy: Helps strengthen the muscles around the knee to improve function and reduce pain.
