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Zilacaine Patch

Zilacaine Patch contains lidocaine, a local anesthetic that provides temporary relief of pain in affected areas by numbing the skin. It is commonly used to treat nerve pain (neuropathy), such as pain following shingles (post-herpetic neuralgia), and other localized pain conditions. The patch delivers lidocaine directly to the skin, reducing discomfort without affecting the entire body.



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Frequently Asked Questions

How long does it take for the Zilacaine Patch to start working?
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The Zilacaine Patch typically starts providing pain relief within 30 minutes to 1 hour after application.

Can I wear the Zilacaine Patch while exercising?
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Yes, but avoid intense activities that cause excessive sweating, as this may affect the adhesion of the patch.

Can I cut the patch to fit a smaller area?
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Yes, the patch can be cut into smaller pieces if needed, as long as the total surface area applied does not exceed the recommended dosage.

What should I do if the patch causes skin irritation?
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If mild irritation occurs, try rotating application sites or reducing the application time. If severe irritation persists, discontinue use and consult your healthcare provider.

Is it safe to use the Zilacaine Patch during pregnancy?
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The safety of lidocaine during pregnancy has not been well studied. Consult your healthcare provider before using this medication if you are pregnant or breastfeeding.

Comprehensive Drug Guide

How Does Zilacaine Patch Work?

Lidocaine works by blocking sodium channels in nerve cells, which prevents pain signals from reaching the brain. By numbing the localized area, the Zilacaine Patch provides targeted pain relief without systemic side effects. The patch can help reduce burning, stabbing, or aching pain associated with nerve damage or skin injuries.



Common Dosages

  • Each Zilacaine Patch typically contains 5% lidocaine in a topical patch form. The common recommendation is to apply the patch for 12 hours on, followed by 12 hours off.

Typical Dosing

  • Apply one Zilacaine Patch to the painful area for up to 12 hours, followed by a 12-hour break. Do not use more than three patches at once, and avoid exceeding 12 hours of application in a 24-hour period.
  • The patch may be cut into smaller pieces to fit the size of the pain area if needed.


Typical Dosing

FDA Approved Indications

  • Relief of post-herpetic neuralgia (nerve pain following shingles)
  • Temporary relief of localized pain in other nerve conditions or injury sites


Who Shouldn't Take Zilacaine Patch?

  • Known hypersensitivity to lidocaine or other amide-type local anesthetics
  • Severe liver disease (which may impair the body’s ability to metabolize lidocaine)


Advice From The Pharmacist

  • Apply the patch to clean, dry skin. Do not apply the patch to irritated, broken, or infected skin.
  • Avoid heat exposure (e.g., heating pads, hot tubs) while wearing the patch, as it may increase the absorption of lidocaine and risk side effects.
  • If the patch becomes loose, remove it and apply a new one to a different area of skin.
  • Wash your hands thoroughly after handling the patch to avoid contact with your eyes or mouth.


Side Effects of Zilacaine Patch

Common Side Effects

  • Mild skin irritation or redness at the application site
  • Numbness or tingling in the area of application


Uncommon/Severe Side Effects

  • Allergic reactions such as rash, itching, or swelling
  • Systemic absorption leading to dizziness, confusion, or irregular heart rhythms (more likely if used improperly)


Risks and Warnings of Zilacaine Patch

  • Overuse: Using the patch for more than 12 hours in a 24-hour period or applying multiple patches can lead to excessive absorption of lidocaine, which may cause serious side effects such as dizziness, seizures, or heart arrhythmias.
  • Allergic Reactions: Although rare, some individuals may develop an allergic reaction to lidocaine. Discontinue use and seek medical attention if any signs of an allergic reaction appear.


Interactions with Zilacaine Patch

Common Drug Interactions

  • Antiarrhythmic drugs: Taking Zilacaine Patch alongside other antiarrhythmic medications (like amiodarone or procainamide) can increase the risk of side effects related to the heart.
  • Beta-blockers: These drugs may slow the metabolism of lidocaine, leading to increased levels in the blood.


Alternatives to Zilacaine Patch

  • Lidoderm (lidocaine 5%): Another prescription topical patch used for the same indication of nerve pain relief.
  • Capsaicin cream: A topical pain relief option derived from chili peppers, which works by reducing substance P in nerve endings.
  • Oral pain relievers: NSAIDs such as ibuprofen or acetaminophen may be used for general pain relief but do not target nerve pain as effectively as lidocaine patches.