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Zegerid
Zegerid is a combination of omeprazole (a proton pump inhibitor) and sodium bicarbonate. It is used to treat conditions caused by excess stomach acid, such as gastroesophageal reflux disease (GERD), erosive esophagitis, gastric ulcers, and duodenal ulcers. Omeprazole works by reducing the amount of acid the stomach produces, while sodium bicarbonate helps neutralize stomach acid and protects the omeprazole from being broken down in the stomach before it can be absorbed.
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Frequently Asked Questions
How quickly does Zegerid work?
Zegerid begins to reduce stomach acid within 30 minutes to an hour, but full relief of symptoms may take a few days.
Can I take Zegerid long-term?
Zegerid can be used long-term under medical supervision. However, long-term use may increase the risk of bone fractures, magnesium deficiency, and vitamin B12 deficiency.
Is Zegerid safe for people with high blood pressure?
Zegerid contains a significant amount of sodium, which can raise blood pressure in some people. If you have hypertension or heart failure, consult your doctor before taking Zegerid.
Can Zegerid be taken with other acid-reducing medications?
It’s best to avoid taking Zegerid with other proton pump inhibitors or antacids, as it may alter their effectiveness. Always consult your doctor before combining medications.
What should I do if I miss a dose of Zegerid?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
Comprehensive Drug Guide
How Does Zegerid Work?
- Omeprazole: A proton pump inhibitor that blocks the final step in acid production in the stomach, significantly reducing the amount of acid produced.
- Sodium bicarbonate: An antacid that helps to neutralize existing stomach acid and protects omeprazole from degradation, allowing it to be absorbed more effectively.
Common Dosages
- Capsules: 20 mg/1100 mg (omeprazole/sodium bicarbonate) and 40 mg/1100 mg
- Oral suspension: 20 mg/1680 mg and 40 mg/1680 mg
Typical Dosing
- For GERD and erosive esophagitis: The usual dose is one capsule or suspension (20 mg or 40 mg of omeprazole) once daily, usually taken in the morning before a meal. Treatment duration may vary depending on the condition.
- For duodenal ulcers: One capsule or suspension (20 mg of omeprazole) once daily for up to 4 weeks, with the option to extend treatment if healing is not complete.
Typical Dosing
FDA Approved Indications
- Gastroesophageal reflux disease (GERD)
- Erosive esophagitis
- Active duodenal ulcer
- Gastric ulcers
- Reduction of risk of upper GI bleeding in critically ill patients
Who Shouldn't Take Zegerid?
- Known hypersensitivity to omeprazole, sodium bicarbonate, or any component of the formulation
- Metabolic alkalosis or conditions where a rapid increase in sodium intake could be harmful
- Severe hypocalcemia
Advice From The Pharmacist
- Take Zegerid on an empty stomach, at least 1 hour before a meal for optimal absorption.
- Do not crush or chew the capsules; they should be swallowed whole.
- Zegerid contains a significant amount of sodium. Patients on low-sodium diets or with conditions like hypertension or heart failure should consult their doctor before use.
- It may take several days to feel the full effects of Zegerid for acid-related conditions, so continue taking it as directed, even if you feel better.
- Be aware of long-term risks, such as reduced absorption of calcium, magnesium, or vitamin B12, if used over an extended period.
Side Effects of Zegerid
Common Side Effects
- Headache
- Nausea
- Stomach pain or bloating
- Diarrhea
- Gas
Uncommon/Severe Side Effects
- Low magnesium levels (symptoms include muscle cramps, seizures, and abnormal heartbeats)
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Increased risk of bone fractures (especially with long-term use)
- Clostridium difficile infection (severe diarrhea)
Risks and Warnings of Zegerid
- Sodium overload: Each dose of Zegerid contains a high amount of sodium bicarbonate, which could be harmful for people with heart conditions, high blood pressure, or kidney disease.
- Bone fractures: Long-term use of proton pump inhibitors like Zegerid has been associated with an increased risk of bone fractures, particularly in the hip, wrist, or spine.
- Magnesium deficiency: Long-term use may cause low magnesium levels, which can result in muscle spasms, irregular heartbeat, or seizures. Patients may need regular blood tests to monitor their magnesium levels.
Interactions with Zegerid
Common Drug Interactions
- Clopidogrel: Zegerid may reduce the effectiveness of this blood thinner, increasing the risk of blood clots.
- Ketoconazole and itraconazole: Zegerid may reduce the absorption of certain antifungal medications, making them less effective.
- Diuretics: Combining Zegerid with diuretics may increase the risk of low magnesium levels.
- Antacids: Other antacids should not be used at the same time as Zegerid, as they may reduce its effectiveness.
Alternatives to Zegerid
- Nexium (esomeprazole): A proton pump inhibitor that works similarly to Zegerid for GERD and ulcers.
- Prilosec (omeprazole): Another form of omeprazole, without the added sodium bicarbonate.
- Prevacid (lansoprazole): A proton pump inhibitor used to treat GERD and other acid-related conditions.
- Pepcid (famotidine): An H2 blocker that reduces stomach acid but through a different mechanism.
