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Yupelri
Yupelri (revefenacin) is a long-acting muscarinic antagonist (LAMA) used for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It works by relaxing the muscles in the airways, helping to keep them open, and making breathing easier. Yupelri is intended for long-term, once-daily use to improve lung function and reduce COPD symptoms but is not used for the relief of acute bronchospasm (sudden difficulty breathing).
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Frequently Asked Questions
How long does it take for Yupelri to work?
Yupelri is a maintenance medication, and while it may start improving lung function within a few hours, it is intended for long-term control of COPD symptoms rather than immediate relief.
Can Yupelri be used during an asthma attack?
No, Yupelri is not a rescue medication. It is used for the long-term management of COPD and should not be used to treat acute asthma or COPD attacks. Use a rescue inhaler for sudden symptoms.
Can I use Yupelri with other inhalers?
Consult your doctor before using Yupelri with other inhalers, as combining different types of inhalers can increase the risk of side effects or reduce the effectiveness of the medications.
What should I do if I miss a dose?
If you miss a dose of Yupelri, take it as soon as you remember, unless it’s close to the time of your next scheduled dose. Do not double up doses to make up for a missed one.
Can I stop using Yupelri if my symptoms improve?
No, you should not stop using Yupelri without consulting your healthcare provider. It is meant to be used as a long-term maintenance treatment, and stopping it abruptly may worsen COPD symptoms.
Comprehensive Drug Guide
How Does Yupelri Work?
Revefenacin, the active ingredient in Yupelri, works by inhibiting muscarinic receptors in the airways, specifically the M3 receptor, which is responsible for causing bronchoconstriction. By blocking these receptors, Yupelri helps relax the airway muscles, reduces airway resistance, and promotes bronchodilation (widening of the airways). This leads to improved airflow and easier breathing for individuals with COPD.
Common Dosages
- 175 mcg/3 mL single-use vials for nebulization.
Typical Dosing
- The typical dose is one vial (175 mcg/3 mL) of Yupelri once daily, inhaled through a nebulizer. It should be used at the same time each day.
- The solution is administered via a standard jet nebulizer connected to an air compressor.
Typical Dosing
FDA Approved Indications
- The maintenance treatment of COPD, including chronic bronchitis and emphysema, in adult patients.
Who Shouldn't Take Yupelri?
- Known hypersensitivity to revefenacin or any component of the formulation.
- Severe hypersensitivity reactions (e.g., anaphylaxis) to other anticholinergic drugs.
Advice From The Pharmacist
- Use Yupelri once daily at the same time each day. Do not use more than the prescribed dose.
- Make sure to use Yupelri with a nebulizer as prescribed. Do not mix it with other medications in the nebulizer unless instructed by your doctor.
- Yupelri is for long-term maintenance of COPD and should not be used for acute bronchospasm or breathing emergencies. Always carry a rescue inhaler for sudden symptoms.
- Store Yupelri vials in a cool, dry place, and use each vial immediately after opening.
Side Effects of Yupelri
Common Side Effects
- Cough
- Runny or stuffy nose
- Upper respiratory tract infections
- Headache
- Dry mouth
Uncommon/Severe Side Effects
- Worsening of breathing problems, such as paradoxical bronchospasm (sudden difficulty breathing after using the medication)
- Hypersensitivity reactions, such as rash, itching, swelling, or difficulty breathing
- Urinary retention, particularly in patients with pre-existing urinary conditions
Risks and Warnings of Yupelri
- Paradoxical Bronchospasm: In rare cases, Yupelri may cause paradoxical bronchospasm, where breathing worsens after using the medication. If this occurs, discontinue use and seek immediate medical attention.
- Urinary Retention: Yupelri can cause difficulty in urination, particularly in patients with benign prostatic hyperplasia (BPH) or bladder obstruction. If you experience painful urination or difficulty urinating, inform your healthcare provider.
- Eye Effects: Accidental exposure of Yupelri to the eyes may cause blurred vision or worsen narrow-angle glaucoma. Avoid contact with the eyes, and wash them immediately if the solution gets in your eyes.
Interactions with Yupelri
Common Drug Interactions
- Anticholinergic drugs: Using Yupelri with other anticholinergic medications may increase the risk of anticholinergic side effects, such as dry mouth or urinary retention.
- Other inhaled medications: Consult your healthcare provider before combining Yupelri with other inhaled COPD treatments.
Alternatives to Yupelri
- Tiotropium (Spiriva): Another long-acting muscarinic antagonist (LAMA) used for the maintenance treatment of COPD.
- Aclidinium (Tudorza Pressair): A LAMA inhaler for COPD management.
- Umeclidinium (Incruse Ellipta): Another LAMA inhaler used for once-daily maintenance of COPD.
- Glycopyrrolate (Seebri Neohaler): A long-acting muscarinic antagonist used for COPD maintenance treatment.
