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Xiidra
Xiidra (lifitegrast) is a prescription eye drop used to treat the symptoms of dry eye disease in adults. Dry eye disease occurs when there is an issue with tear production or quality, leading to discomfort, stinging, and blurred vision. Xiidra works by reducing inflammation in the eyes, helping to relieve the symptoms of dry eye disease and improve tear production.
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Frequently Asked Questions
How long does it take for Xiidra to start working?
Some patients may notice improvements in dry eye symptoms within 2 weeks, but it may take up to 12 weeks to see the full benefit of Xiidra.
Can I use Xiidra if I wear contact lenses?
Yes, but you should remove your contact lenses before using Xiidra and wait at least 15 minutes before reinserting them.
What should I do if I miss a dose of Xiidra?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Can I use Xiidra with other eye medications?
Yes, but it is important to wait at least 5 minutes between applying Xiidra and any other eye medications to avoid dilution or interference.
Does Xiidra cause blurred vision?
Yes, temporary blurred vision may occur after applying Xiidra. Avoid driving or operating machinery until your vision clears.
Comprehensive Drug Guide
How Does Xiidra Work?
Xiidra works by inhibiting LFA-1 (lymphocyte function-associated antigen-1), a protein involved in the inflammatory process associated with dry eye disease. By blocking LFA-1, Xiidra reduces inflammation on the surface of the eye, allowing for better tear production and relieving the symptoms of dry eye.
Common Dosages
- One drop in each eye twice daily (approximately every 12 hours).
Typical Dosing
- Apply one drop of Xiidra to each eye twice daily (morning and evening), spaced approximately 12 hours apart. Each vial is intended for single use only, so discard the vial after use, even if there is some solution left.
Typical Dosing
FDA Approved Indications
- Dry eye disease (also known as keratoconjunctivitis sicca) in adults.
Who Shouldn't Take Xiidra?
- Known hypersensitivity to lifitegrast or any components of the formulation.
- There are no major contraindications, but patients should avoid using Xiidra in cases of active eye infections unless directed by a healthcare provider.
Advice From The Pharmacist
- Wash your hands before using Xiidra to avoid contamination.
- Tilt your head back and apply one drop into each eye. Do not let the tip of the dropper touch your eye or any surface to prevent contamination.
- After applying Xiidra, blink a few times to help spread the solution across your eye. You may experience a temporary metallic taste or burning sensation in your mouth after using the drops, which is normal and should pass quickly.
- If you wear contact lenses, remove them before applying Xiidra and wait at least 15 minutes before reinserting them.
- If you are using other eye medications, wait at least 5 minutes between applying different products.
Side Effects of Xiidra
Common Side Effects
- Eye irritation (burning or stinging)
- Blurred vision immediately after application
- Unusual taste (metallic taste)
- Eye redness
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, difficulty breathing)
- Increased eye discomfort or signs of an eye infection (redness, swelling, discharge)
Risks and Warnings of Xiidra
- Eye Irritation: Some patients may experience mild eye discomfort or irritation upon applying Xiidra. If the irritation persists or worsens, contact your healthcare provider.
- Contact Lens Wearers: Xiidra should not be applied while wearing contact lenses. Remove lenses before use and wait at least 15 minutes before reinserting them.
- Contamination Risk: Be careful not to touch the dropper tip to any surface, including your eye, to avoid contamination, which can lead to an eye infection.
Interactions with Xiidra
Common Drug Interactions
- There are no known significant drug interactions with Xiidra due to its local administration in the eyes. However, inform your healthcare provider of any other medications or eye treatments you are using to ensure compatibility.
Alternatives to Xiidra
- Restasis (cyclosporine): Another prescription eye drop used to treat chronic dry eye by increasing tear production through an immunosuppressive mechanism.
- Artificial tears: Over-the-counter lubricating eye drops that provide temporary relief of dry eye symptoms, though they do not treat the underlying cause of dry eye disease.
- Punctal plugs: Small devices inserted into the tear ducts to help retain moisture on the eye’s surface, used in more severe cases of dry eye.
