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Xerese
Xerese (generic name: acyclovir and hydrocortisone) is a topical cream used to treat cold sores (herpes labialis) caused by the herpes simplex virus (HSV). It combines the antiviral properties of acyclovir with the anti-inflammatory effects of hydrocortisone. This dual-action approach helps reduce the severity and duration of cold sores while minimizing inflammation and symptoms like itching and redness.
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Frequently Asked Questions
How quickly does Xerese start working?
Xerese should be applied at the first sign of a cold sore (e.g., tingling, itching), and it typically starts working to reduce symptoms within 1 to 2 days of treatment.
Can Xerese prevent cold sores from appearing?
While Xerese cannot prevent cold sores from forming entirely, using it early in an outbreak can reduce the severity and duration of symptoms.
What should I do if I miss a dose of Xerese?
If you miss a dose, apply it as soon as you remember, then continue with your regular dosing schedule. Do not double up on doses.
Can I use Xerese for longer than 5 days if my cold sore hasn’t healed?
You should not use Xerese for more than 5 days unless instructed by your healthcare provider. If your cold sore has not healed, consult your healthcare provider for further guidance.
Is Xerese safe to use on children?
Xerese is approved for use in adolescents aged 12 and older. Consult a healthcare provider before using it in younger children.
Comprehensive Drug Guide
How Does Xerese Work?
Xerese combines acyclovir, which works by inhibiting the replication of the herpes simplex virus, and hydrocortisone, which reduces inflammation by suppressing immune responses that cause swelling, redness, and itching. The antiviral component helps stop the virus from multiplying, while the corticosteroid component helps relieve the symptoms associated with the cold sore.
Common Dosages
- Acyclovir 5% / Hydrocortisone 1% cream
Typical Dosing
- The typical dosing of Xerese is to apply a thin layer of the cream to the affected area, covering the cold sore and the surrounding area, 5 times daily for 5 days.
- Treatment should begin as soon as possible after the first signs of a cold sore (e.g., tingling, redness, or itching).
Typical Dosing
FDA Approved Indications
- Treatment of recurrent herpes labialis (cold sores) in adults and adolescents aged 12 years and older.
Who Shouldn't Take Xerese?
- Known hypersensitivity to acyclovir, valacyclovir, hydrocortisone, or any component of the formulation.
- Skin infections or conditions other than cold sores.
Advice From The Pharmacist
- Start using Xerese at the first sign of a cold sore (e.g., tingling, itching, or redness) to achieve the best results.
- Wash your hands before and after applying the cream to prevent spreading the virus to other areas or people.
- Avoid touching or scratching the affected area to prevent the spread of the infection.
- Do not cover the cold sore with bandages or occlusive dressings while using Xerese.
Side Effects of Xerese
Common Side Effects
- Dryness or flakiness of the skin at the application site
- Itching or mild irritation
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Skin thinning (with prolonged use of hydrocortisone)
Risks and Warnings of Xerese
- Avoid long-term use: Prolonged use of corticosteroids like hydrocortisone can cause skin thinning. Use Xerese only for the prescribed duration.
- External use only: Xerese should only be applied to the skin. Avoid contact with the eyes or inside the mouth. If accidental contact occurs, rinse thoroughly with water.
- Not for genital herpes: Xerese is specifically indicated for cold sores (herpes labialis) and should not be used to treat genital herpes or other types of viral infections.
Interactions with Xerese
Common Drug Interactions
- Other topical corticosteroids: Avoid using other products containing corticosteroids on the same area as Xerese, as this may increase the risk of side effects like skin thinning.
- Other antiviral medications: There are no known significant interactions between Xerese and systemic antiviral medications, but always inform your healthcare provider of all medications you are using.
Alternatives to Xerese
- Acyclovir cream (Zovirax): A topical antiviral used to treat herpes simplex virus infections, including cold sores.
- Penciclovir (Denavir): Another antiviral cream used to treat cold sores and shorten healing time.
- Docosanol (Abreva): An over-the-counter topical cream for treating cold sores.
