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Acyclovir
Acyclovir is an antiviral medication that treats the symptoms, such as pain, and speeds up the healing process of varicella (chicken pox), herpes zoster (shingles), herpes labialis (cold sores), and genital herpes. This medication slows the growth and spread of the virus so the body can fight it. It does not cure genital herpes, but it may prevent the transmission of genital herpes to others when used daily and can be used to prevent outbreaks when the virus already exists. It will not stop the transmission of cold sores but it may prevent the spread to new areas on the body if used correctly. Some common side effects include nausea, vomiting, diarrhea, and headaches.
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Frequently Asked Questions
Can Acyclovir affect fertility or my ability to conceive?
There's no evidence to suggest that Acyclovir has any effect on a person's ability to conceive. However, it's always best to discuss this with your doctor if you have any concerns.
Can I consume alcohol while taking Acyclovir?
While there is no specific interaction between Acyclovir and alcohol, drinking alcohol can make side effects, like dizziness or headaches, worse. It's always best to limit alcohol consumption while on medication.
Does Acyclovir cure herpes?
No, it doesn't cure herpes, but it can reduce the severity and frequency of outbreaks.
Does Acyclovir have to be taken for life?
Not usually. It is typically taken for a short period for treating outbreaks or for a longer period to reduce the number of herpes outbreaks.
How quickly does Acyclovir work?
It generally starts to work within 2448 hours of starting the medication, but it's most effective if started within 72 hours of the onset of a herpes outbreak.
Will Acyclovir prevent transmission of herpes virus?
No, herpes can be transmitted even if you are on Acyclovir. Practicing safer sex and using condoms can help reduce the risk of transmission.
Comprehensive Drug Guide
How Does Acyclovir Work?
Acyclovir is a synthetic purine nucleoside analog that inhibits the replication of herpes simplex viruses (HSV1 and HSV2), varicellazoster virus (VZV), and EpsteinBarr virus (EBV).
What is Acyclovir Used For?
FDA indications: Acyclovir is used to treat virus infections of the skin, lips, and genitals; herpes zoster (shingles); and chickenpox.
Offlabel uses: It's also been used to prevent cytomegalovirus (CMV) disease following organ transplantation and for treating EpsteinBarr virus (EBV) infections.
Common Dosages
Tablets: 200mg, 400mg, 800mg
Oral solution: 200mg/5mL
Typical Dosing
FDA Approved Indications
- Herpes simplex labialis (cold sores): 200mg every 4 hours, five times daily, for 5 days.
- Genital herpes: 200mg every 4 hours, five times daily, for 710 days.
- Shingles: 800mg every 4 hours, five times daily, for 710 days.
- Chickenpox: 800mg four times daily for 5 days.
Off-Label Uses
- CMV prevention: 400mg four times daily.
- EpsteinBarr virus: dosing can vary and will be determined by your healthcare provider.
Who Shouldn't Take Acyclovir?
- Are allergic to acyclovir, valacyclovir, or any inactive ingredient in the product.
- Have kidney problems.
- Have a weak immune system.
- Are dehydrated.
- Are pregnant, planning to become pregnant, or breastfeeding.
- Some medicines can interact with acyclovir and increase the risk of side effects. For example, probenecid and tenofovir.
Advice From The Pharmacist
- Take the medicine as soon as the first symptom occurs (such as tingling, burning, or blisters).
- Drink plenty of fluids while taking acyclovir to keep your kidneys working properly.
- Continue taking acyclovir for the full prescribed length of time, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
- Keep taking it even if you feel better in a few days.
- Don?t stop the medicine without talking to your doctor.
Side Effects of Acyclovir
Common Side Effects
- You might experience nausea, diarrhea, or headache.
- You might feel tired or experience general discomfort.
Uncommon/Severe Side Effects
- If you experience severe dizziness, rapid weight gain, or changes in mental mood, you need immediate medical help.
- Signs of a serious allergic reaction like rash, itching or swelling of the face/tongue/throat, severe dizziness, or trouble breathing need immediate medical attention.
Risks and Warnings of Acyclovir
- It's important to remember that Acyclovir, while typically welltolerated, is not suitable for everyone.
- Those with kidney problems should take it cautiously, and doctors may adjust the dose accordingly.
- Likewise, individuals with a weakened immune system, a condition known as immunosuppression, need to consult a healthcare provider before using Acyclovir.
- If you are considering pregnancy, are already pregnant, or are breastfeeding, discuss the potential risks and benefits of this medication with your doctor.
- Make sure to discuss your full medical history with your physician, including any allergies or ongoing treatments, as Acyclovir can interact unfavorably with other medicines, such as probenecid and tenofovir.
Interactions with Acyclovir
Common Drug Interactions
- Probenecid
- Tenofovir
- Other antivirals
Alternatives to Acyclovir
- Valacyclovir
- Famciclovir
- Penciclovir
- Docosanol
- Brivudine
