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Xelstrym
Xelstrym (generic name: dextroamphetamine transdermal system) is a stimulant medication used to treat Attention-Deficit/Hyperactivity Disorder (ADHD) in patients aged 6 years and older. Xelstrym is unique in that it is delivered via a transdermal patch, providing a consistent release of dextroamphetamine over time. This helps manage symptoms of inattention, hyperactivity, and impulsivity by enhancing the activity of certain neurotransmitters in the brain, particularly dopamine and norepinephrine.
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Frequently Asked Questions
How long does Xelstrym take to start working?
Xelstrym typically starts to work within 1 to 2 hours after applying the patch, with effects lasting for up to 9 hours.
Can I shower or swim with the Xelstrym patch on?
Yes, the patch is designed to stay in place during regular activities, including showering or swimming. However, avoid soaking in hot water or applying heat directly to the patch.
What should I do if the Xelstrym patch falls off?
If the patch falls off before 9 hours, reapply it or replace it with a new one if necessary. Do not exceed the prescribed dose.
Can Xelstrym cause weight loss?
Yes, loss of appetite and weight loss are common side effects of stimulant medications like Xelstrym. Children using this medication should have their growth monitored regularly.
How should I dispose of the Xelstrym patch?
After removing the patch, fold it in half so that the sticky sides stick together, and dispose of it in a trash container that is out of reach of children and pets. Do not flush it down the toilet.
Comprehensive Drug Guide
How Does Xelstrym Work?
Xelstrym works by increasing the levels of dopamine and norepinephrine in the brain. These neurotransmitters are involved in regulating attention, focus, and behavior. By enhancing their activity, Xelstrym helps improve attention span, reduce hyperactivity, and manage impulsive behaviors associated with ADHD.
Common Dosages
- 4.5 mg/9 hours
- 9 mg/9 hours
- 13.5 mg/9 hours
- 18 mg/9 hours
Typical Dosing
- The recommended starting dose is one patch applied daily, typically starting with the lowest dose and adjusting as needed. The patch should be applied to a clean, dry, intact area of skin and worn for up to 9 hours.
- The dose may be adjusted based on patient response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in patients aged 6 years and older.
Who Shouldn't Take Xelstrym?
- A history of drug abuse
- Known hypersensitivity to dextroamphetamine or any other ingredients in the patch
- Glaucoma
- Use of monoamine oxidase inhibitors (MAOIs) within the last 14 days
Advice From The Pharmacist
- Apply the Xelstrym patch to a clean, dry, intact area of the skin, such as the upper arm, hip, or chest. Rotate application sites daily to avoid skin irritation.
- Avoid exposing the patch to direct heat sources (e.g., heating pads, hot water) as this can increase the release of the medication and lead to overdose.
- Do not cut the patch, as this may affect the release mechanism of the medication.
- Remove the patch after 9 hours or earlier if advised by your healthcare provider.
Side Effects of Xelstrym
Common Side Effects
- Insomnia
- Loss of appetite
- Irritability
- Dry mouth
- Nausea
Uncommon/Severe Side Effects
- Increased heart rate or blood pressure
- Mood changes or signs of psychosis
- Growth suppression in children with long-term use
Risks and Warnings of Xelstrym
- Abuse and Dependence: Xelstrym, like other stimulant medications, has a high potential for abuse and dependence. It should be used with caution, especially in individuals with a history of substance abuse.
- Cardiovascular Effects: Xelstrym may increase heart rate and blood pressure. Patients with a history of cardiovascular disease should be monitored closely while using this medication.
- Psychiatric Effects: Stimulants like Xelstrym can exacerbate symptoms of psychosis or cause new psychiatric symptoms, such as mania or aggression, especially in individuals with pre-existing mental health conditions.
Interactions with Xelstrym
Common Drug Interactions
- Monoamine Oxidase Inhibitors (MAOIs): Using Xelstrym with MAOIs can result in dangerous interactions, including hypertensive crises.
- Antihypertensive medications: Stimulants like Xelstrym may reduce the effectiveness of blood pressure medications.
- Other stimulant medications: Combining Xelstrym with other stimulants can increase the risk of side effects, such as increased heart rate and blood pressure.
Alternatives to Xelstrym
- Adderall XR (amphetamine/dextroamphetamine): A long-acting stimulant medication commonly used to treat ADHD.
- Vyvanse (lisdexamfetamine): A stimulant used for ADHD that is less prone to abuse due to its prodrug formulation.
- Concerta (methylphenidate ER): A long-acting stimulant alternative for ADHD.
- Strattera (atomoxetine): A non-stimulant option for the treatment of ADHD.
