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Xcopri (250 MG Daily Dose)
Xcopri (generic name: cenobamate) is an antiepileptic drug (AED) used to treat partial-onset seizures in adults. It is commonly prescribed when other medications have not provided adequate seizure control. Xcopri works by reducing the abnormal electrical activity in the brain that leads to seizures. The 250 mg daily dose is often part of a maintenance regimen after gradually increasing the dosage over several weeks.
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Frequently Asked Questions
How long does it take for Xcopri to start working?
Xcopri starts reducing seizure frequency during the titration period, but full effects may take several weeks to achieve as the dose is gradually increased.
What should I do if I miss a dose of Xcopri?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double up on doses.
Can Xcopri be used as monotherapy?
Yes, Xcopri can be used as monotherapy or in combination with other antiepileptic drugs for the treatment of partial-onset seizures.
Can I stop taking Xcopri abruptly?
No, stopping Xcopri suddenly can lead to an increased risk of seizures. Always consult your healthcare provider before discontinuing or tapering off the medication.
Is Xcopri safe for long-term use?
Yes, Xcopri is intended for long-term use to manage seizures. Regular follow-up with your healthcare provider is necessary to monitor your response to treatment and adjust the dose as needed.
Comprehensive Drug Guide
How Does Xcopri (250 MG Daily Dose) Work?
Cenobamate, the active ingredient in Xcopri, works by modulating voltage-gated sodium channels and enhancing GABA-mediated inhibitory neurotransmission. This helps stabilize hyperexcitable neurons and reduce the frequency of seizures.
Common Dosages
- Initial dose: Start with 12.5 mg once daily and gradually increase the dose over several weeks.
- Maintenance dose: Once the patient reaches 250 mg daily, this dose may be continued, or the dose may be increased to a maximum of 400 mg daily if needed.
Typical Dosing
- Xcopri is usually started at 12.5 mg once daily, with the dose increasing weekly or biweekly to minimize side effects.
- After titration, the maintenance dose is 250 mg once daily. Some patients may require a dose adjustment based on their response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of partial-onset seizures in adults.
Who Shouldn't Take Xcopri (250 MG Daily Dose)?
- Hypersensitivity to cenobamate or any of its ingredients.
- Familial short QT syndrome, as Xcopri can affect heart rhythm and may cause QT interval shortening, increasing the risk of arrhythmias.
Advice From The Pharmacist
- Take Xcopri exactly as prescribed: Follow the dosing schedule provided by your healthcare provider and do not skip doses, as this may lead to breakthrough seizures.
- Do not stop taking Xcopri suddenly, as this can increase the risk of seizure recurrence. Always taper off the medication gradually under the supervision of your healthcare provider.
- Be cautious with alcohol: Drinking alcohol while taking Xcopri can increase drowsiness and dizziness.
- Report any changes in mood, such as increased depression or suicidal thoughts, to your healthcare provider.
Side Effects of Xcopri (250 MG Daily Dose)
Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Nausea
- Headache
Uncommon/Severe Side Effects
- Shortening of the QT interval (potential for heart arrhythmias)
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Suicidal thoughts or behavior changes
Risks and Warnings of Xcopri (250 MG Daily Dose)
- QT Interval Shortening: Xcopri can shorten the QT interval, which may increase the risk of arrhythmias. It is contraindicated in patients with familial short QT syndrome.
- Suicidal Thoughts and Behavior: Like other antiepileptic drugs, Xcopri may increase the risk of suicidal thoughts or behavior. Patients should be closely monitored for mood changes, depression, or suicidal ideation.
- CNS Depression: Xcopri can cause drowsiness, dizziness, and fatigue, which may impair the ability to perform tasks that require alertness, such as driving or operating machinery.
Interactions with Xcopri (250 MG Daily Dose)
Common Drug Interactions
- Alcohol and CNS depressants: Combining Xcopri with alcohol or other central nervous system depressants (e.g., benzodiazepines) can increase the risk of sedation and other CNS side effects.
- Phenytoin: Xcopri can increase phenytoin levels, so dose adjustments of phenytoin may be needed.
- Carbamazepine: Xcopri may decrease the levels of carbamazepine, so dose adjustments of carbamazepine may be necessary.
Alternatives to Xcopri (250 MG Daily Dose)
- Lamotrigine (Lamictal): An anticonvulsant used to treat partial-onset and generalized seizures.
- Levetiracetam (Keppra): Used for partial and generalized seizures.
- Topiramate (Topamax): A broad-spectrum anticonvulsant used for seizures and migraine prevention.
- Lacosamide (Vimpat): Another option for partial-onset seizures.
