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Keppra
Levetiracetam is an anti-epileptic drug, also known as an anticonvulsant. It is used to treat partial-onset seizures in people with epilepsy. Levetiracetam works by decreasing abnormal excitement in the brain. Some common side effects include drowsiness, weakness, and infection, but consult your physician immediately if you experience more severe effects.
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Frequently Asked Questions
Can I stop taking levetiracetam abruptly?
No, you should taper off under the supervision of your doctor. Abrupt withdrawal can cause an increase in seizure frequency.
Does levetiracetam affect hormonal birth control?
No, levetiracetam does not interact with hormonal birth control methods.
What should I do if I miss a dose of levetiracetam?
You should take it as soon as you remember but skip the missed dose if it is close to your next dose. Never double your dose to make up for a missed one.
Can I take levetiracetam if I am pregnant?
You should consult your healthcare provider as this medication is categorized as pregnancy category C.
Can children take levetiracetam?
Yes, when prescribed by a healthcare provider, but the dose is based on weight. Regular follow-ups are required to monitor growth in children taking long-term levetiracetam.
Comprehensive Drug Guide
How Does Keppra Work?
Levetiracetam is an antiepileptic drug that works by modulation of neurotransmitter release through binding to a specific synaptic vesicle protein, SV2A. It reduces the hyper-synchronization of epileptiform burst firing and propagation of seizure activity.
What is Keppra Used For?
FDA indications: Levetiracetam is used in combination with other medications to treat seizures in adults with epilepsy.
Off-label uses: It's also been used for the off-label treatment of bipolar disorder, anxiety disorders, and certain types of pain.
Common Dosages
Tablets: 250mg, 500mg, 750mg, 1000mg
Oral solution: 100mg/mL
Injection: 100mg/mL
Typical Dosing
FDA Approved Indications
- For FDA-approved indications:
- Seizures start with a loading dose of 10 to 20mg per kilogram of body weight, followed by 20 to 60mg per kilogram per day, divided into two doses
Off-Label Uses
- For off-label uses:
- Bipolar disorder: 250 to 750mg twice daily.
- Anxiety disorders: 250 to 750mg twice daily.
- Certain types of pain: 250 to 750mg twice daily.
Who Shouldn't Take Keppra?
- Those who have had an allergic reaction to levetiracetam or any other ingredient in the medication should avoid it.
- If you have moderate to severe kidney impairment, caution needs to be exercised while taking this medication.
- Pregnant, planning to become pregnant, or breastfeeding (it's not known whether levetiracetam harms the baby)
- If you have a history of suicidal thoughts or actions, you need to inform your healthcare provider.
- Have liver disease.
- Have diabetes.
- Have any serious medical conditions
Advice From The Pharmacist
- Always take this medication as prescribed by your doctor.
- This medication should not be stopped suddenly without the advice of your doctor as it may increase your risk of seizures.
- Keep yourself well-hydrated when taking this medication.
- Regular exercise, a balanced diet, and getting enough sleep may help control seizure episodes.
- If you're feeling depressed, or have thoughts of hurting yourself, don't wait to speak to your healthcare provider.
- Refrain from driving or operating heavy machinery until you know how this medication affects you.
- Keep all your doctor's appointments and get regular check-ups.
Side Effects of Keppra
Common Side Effects
- Drowsiness
- Dizziness
- Weakness.
Uncommon/Severe Side Effects
- Rare side effects:
- Serious allergic reaction i.e., rash, itching, or swelling of the face/tongue/throat,
- Severe dizziness
- Trouble breathing.
- Severe side effects:
- If you have severe rash or swelling of your face, lips, or tongue, or difficulty breathing, you should get emergency medical attention.
Risks and Warnings of Keppra
- Taking Levetiracetam can increase the risk of thoughts of suicide. It is essential to consult a healthcare provider before using this medication if you have a history of mental health issues.
- Sudden discontinuation can lead to withdrawal seizures.
- This medication should not be used if you're allergic to levetiracetam or any other ingredient in the product.
- Levetiracetam should be used with caution if you have impaired kidney function, as dose adjustments may be required.
- Consult your healthcare provider if you're pregnant, planning to become pregnant, or are breastfeeding.
Interactions with Keppra
Common Drug Interactions
- Other antiepileptic drugs
- Antacids containing aluminum or magnesium
- Oral contraceptives
Alternatives to Keppra
- Carbamazepine
- Gabapentin
- Lamotrigine
- Oxcarbazepine
- Pregabalin
- Topiramate
